Cortical factor feedback model for cellular locomotion and cytofission.

Eukaryotic cells can move spontaneously without being guided by external cues. For such spontaneous movements, a variety of different modes have been observed, including the amoeboid-like locomotion with protrusion of multiple pseudopods, the keratocyte-like locomotion with a widely spread lamellipo...

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Autores principales:	Shin I Nishimura, Masahiro Ueda, Masaki Sasai
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/24490ff1c8a148bfbdacc3c3d245b3de
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spelling	oai:doaj.org-article:24490ff1c8a148bfbdacc3c3d245b3de2021-11-25T05:41:48ZCortical factor feedback model for cellular locomotion and cytofission.1553-734X1553-735810.1371/journal.pcbi.1000310https://doaj.org/article/24490ff1c8a148bfbdacc3c3d245b3de2009-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19282961/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Eukaryotic cells can move spontaneously without being guided by external cues. For such spontaneous movements, a variety of different modes have been observed, including the amoeboid-like locomotion with protrusion of multiple pseudopods, the keratocyte-like locomotion with a widely spread lamellipodium, cell division with two daughter cells crawling in opposite directions, and fragmentations of a cell to multiple pieces. Mutagenesis studies have revealed that cells exhibit these modes depending on which genes are deficient, suggesting that seemingly different modes are the manifestation of a common mechanism to regulate cell motion. In this paper, we propose a hypothesis that the positive feedback mechanism working through the inhomogeneous distribution of regulatory proteins underlies this variety of cell locomotion and cytofission. In this hypothesis, a set of regulatory proteins, which we call cortical factors, suppress actin polymerization. These suppressing factors are diluted at the extending front and accumulated at the retracting rear of cell, which establishes a cellular polarity and enhances the cell motility, leading to the further accumulation of cortical factors at the rear. Stochastic simulation of cell movement shows that the positive feedback mechanism of cortical factors stabilizes or destabilizes modes of movement and determines the cell migration pattern. The model predicts that the pattern is selected by changing the rate of formation of the actin-filament network or the threshold to initiate the network formation.Shin I NishimuraMasahiro UedaMasaki SasaiPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 5, Iss 3, p e1000310 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Shin I Nishimura Masahiro Ueda Masaki Sasai Cortical factor feedback model for cellular locomotion and cytofission.
description	Eukaryotic cells can move spontaneously without being guided by external cues. For such spontaneous movements, a variety of different modes have been observed, including the amoeboid-like locomotion with protrusion of multiple pseudopods, the keratocyte-like locomotion with a widely spread lamellipodium, cell division with two daughter cells crawling in opposite directions, and fragmentations of a cell to multiple pieces. Mutagenesis studies have revealed that cells exhibit these modes depending on which genes are deficient, suggesting that seemingly different modes are the manifestation of a common mechanism to regulate cell motion. In this paper, we propose a hypothesis that the positive feedback mechanism working through the inhomogeneous distribution of regulatory proteins underlies this variety of cell locomotion and cytofission. In this hypothesis, a set of regulatory proteins, which we call cortical factors, suppress actin polymerization. These suppressing factors are diluted at the extending front and accumulated at the retracting rear of cell, which establishes a cellular polarity and enhances the cell motility, leading to the further accumulation of cortical factors at the rear. Stochastic simulation of cell movement shows that the positive feedback mechanism of cortical factors stabilizes or destabilizes modes of movement and determines the cell migration pattern. The model predicts that the pattern is selected by changing the rate of formation of the actin-filament network or the threshold to initiate the network formation.
format	article
author	Shin I Nishimura Masahiro Ueda Masaki Sasai
author_facet	Shin I Nishimura Masahiro Ueda Masaki Sasai
author_sort	Shin I Nishimura
title	Cortical factor feedback model for cellular locomotion and cytofission.
title_short	Cortical factor feedback model for cellular locomotion and cytofission.
title_full	Cortical factor feedback model for cellular locomotion and cytofission.
title_fullStr	Cortical factor feedback model for cellular locomotion and cytofission.
title_full_unstemmed	Cortical factor feedback model for cellular locomotion and cytofission.
title_sort	cortical factor feedback model for cellular locomotion and cytofission.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/24490ff1c8a148bfbdacc3c3d245b3de
work_keys_str_mv	AT shininishimura corticalfactorfeedbackmodelforcellularlocomotionandcytofission AT masahiroueda corticalfactorfeedbackmodelforcellularlocomotionandcytofission AT masakisasai corticalfactorfeedbackmodelforcellularlocomotionandcytofission
_version_	1718414505821601792

Cortical factor feedback model for cellular locomotion and cytofission.

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