Direct comparison of distinct naive pluripotent states in human embryonic stem cells

Human embryonic stem cells (hESCs) in culture display a state of primed pluripotency, but recent protocols have been developed that enable hESCs to adopt a naive-like pluripotent state. Here the authors perform a side-by-side comparison of methods used to culture naive hESCs and confirm the role of...

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Autores principales:	S. Warrier, M. Van der Jeught, G. Duggal, L. Tilleman, E. Sutherland, J. Taelman, M. Popovic, S. Lierman, S. Chuva De Sousa Lopes, A. Van Soom, L. Peelman, F. Van Nieuwerburgh, D. I. M. De Coninck, B. Menten, P. Mestdagh, J. Van de Sompele, D. Deforce, P. De Sutter, B. Heindryckx
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/244cbf649add464c82660353beddd982
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spelling	oai:doaj.org-article:244cbf649add464c82660353beddd9822021-12-02T14:40:24ZDirect comparison of distinct naive pluripotent states in human embryonic stem cells10.1038/ncomms150552041-1723https://doaj.org/article/244cbf649add464c82660353beddd9822017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15055https://doaj.org/toc/2041-1723Human embryonic stem cells (hESCs) in culture display a state of primed pluripotency, but recent protocols have been developed that enable hESCs to adopt a naive-like pluripotent state. Here the authors perform a side-by-side comparison of methods used to culture naive hESCs and confirm the role of PI3K/AKT/mTORC signalling in facilitating the induction of naive pluripotency.S. WarrierM. Van der JeughtG. DuggalL. TillemanE. SutherlandJ. TaelmanM. PopovicS. LiermanS. Chuva De Sousa LopesA. Van SoomL. PeelmanF. Van NieuwerburghD. I. M. De ConinckB. MentenP. MestdaghJ. Van de SompeleD. DeforceP. De SutterB. HeindryckxNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. Warrier M. Van der Jeught G. Duggal L. Tilleman E. Sutherland J. Taelman M. Popovic S. Lierman S. Chuva De Sousa Lopes A. Van Soom L. Peelman F. Van Nieuwerburgh D. I. M. De Coninck B. Menten P. Mestdagh J. Van de Sompele D. Deforce P. De Sutter B. Heindryckx Direct comparison of distinct naive pluripotent states in human embryonic stem cells
description	Human embryonic stem cells (hESCs) in culture display a state of primed pluripotency, but recent protocols have been developed that enable hESCs to adopt a naive-like pluripotent state. Here the authors perform a side-by-side comparison of methods used to culture naive hESCs and confirm the role of PI3K/AKT/mTORC signalling in facilitating the induction of naive pluripotency.
format	article
author	S. Warrier M. Van der Jeught G. Duggal L. Tilleman E. Sutherland J. Taelman M. Popovic S. Lierman S. Chuva De Sousa Lopes A. Van Soom L. Peelman F. Van Nieuwerburgh D. I. M. De Coninck B. Menten P. Mestdagh J. Van de Sompele D. Deforce P. De Sutter B. Heindryckx
author_facet	S. Warrier M. Van der Jeught G. Duggal L. Tilleman E. Sutherland J. Taelman M. Popovic S. Lierman S. Chuva De Sousa Lopes A. Van Soom L. Peelman F. Van Nieuwerburgh D. I. M. De Coninck B. Menten P. Mestdagh J. Van de Sompele D. Deforce P. De Sutter B. Heindryckx
author_sort	S. Warrier
title	Direct comparison of distinct naive pluripotent states in human embryonic stem cells
title_short	Direct comparison of distinct naive pluripotent states in human embryonic stem cells
title_full	Direct comparison of distinct naive pluripotent states in human embryonic stem cells
title_fullStr	Direct comparison of distinct naive pluripotent states in human embryonic stem cells
title_full_unstemmed	Direct comparison of distinct naive pluripotent states in human embryonic stem cells
title_sort	direct comparison of distinct naive pluripotent states in human embryonic stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/244cbf649add464c82660353beddd982
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Direct comparison of distinct naive pluripotent states in human embryonic stem cells

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