Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications

Ruba S Darweesh,1 Nehad M Ayoub,2 Sami Nazzal3 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan; 2Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan; 3De...

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Autores principales:	Darweesh RS, Ayoub NM, Nazzal S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Gold nanoparticles angiogenesis molecular signaling VEGF uptake toxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/244d1eb211c847469b5490358a901142
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spelling	oai:doaj.org-article:244d1eb211c847469b5490358a9011422021-12-02T02:19:54ZGold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications1178-2013https://doaj.org/article/244d1eb211c847469b5490358a9011422019-09-01T00:00:00Zhttps://www.dovepress.com/gold-nanoparticles-and-angiogenesis-molecular-mechanisms-and-biomedica-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ruba S Darweesh,1 Nehad M Ayoub,2 Sami Nazzal3 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan; 2Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan; 3Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Dallas, TX 75235-6411, USACorrespondence: Ruba S DarweeshDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, P.O.Box 3030, Irbid 22110, JordanTel +962 2 720 1000 Ext 26821Fax +962 2 720 1075Email rsdarweesh@just.edu.joAbstract: Angiogenesis is the formation of new blood vessels from pre-existing vessels. It is a highly regulated process as determined by the interplay between pro-angiogenic and anti-angiogenic factors. Under certain conditions the balance between angiogenesis stimulators and inhibitors is altered, which results in a shift from physiological to pathological angiogenesis. Therefore, the goal of therapeutic targeting of angiogenic process is to normalize vasculature in target tissues by enhancing angiogenesis in disease conditions of reduced vascularity and blood flow, such as tissue ischemia, or alternatively to inhibit excessive and abnormal angiogenesis in disorders like cancer. Gold nanoparticles (AuNPs) are special particles that are generated by nanotechnology and composed of an inorganic core containing gold which is encircled by an organic monolayer. The ability of AuNPs to alter vasculature has captured recent attention in medical literature as potential therapeutic agents for the management of pathologic angiogenesis. This review provides an overview of the effects of AuNPs on angiogenesis and the molecular mechanisms and biomedical applications associated with their effects. In addition, the main synthesis methods, physical properties, uptake mechanisms, and toxicity of AuNPs are briefly summarized.Keywords: gold nanoparticles, angiogenesis, molecular signaling, VEGF, uptake, toxicityDarweesh RSAyoub NMNazzal SDove Medical PressarticleGold nanoparticlesangiogenesismolecular signalingVEGFuptaketoxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 7643-7663 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold nanoparticles angiogenesis molecular signaling VEGF uptake toxicity Medicine (General) R5-920
spellingShingle	Gold nanoparticles angiogenesis molecular signaling VEGF uptake toxicity Medicine (General) R5-920 Darweesh RS Ayoub NM Nazzal S Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications
description	Ruba S Darweesh,1 Nehad M Ayoub,2 Sami Nazzal3 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan; 2Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan; 3Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Dallas, TX 75235-6411, USACorrespondence: Ruba S DarweeshDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, P.O.Box 3030, Irbid 22110, JordanTel +962 2 720 1000 Ext 26821Fax +962 2 720 1075Email rsdarweesh@just.edu.joAbstract: Angiogenesis is the formation of new blood vessels from pre-existing vessels. It is a highly regulated process as determined by the interplay between pro-angiogenic and anti-angiogenic factors. Under certain conditions the balance between angiogenesis stimulators and inhibitors is altered, which results in a shift from physiological to pathological angiogenesis. Therefore, the goal of therapeutic targeting of angiogenic process is to normalize vasculature in target tissues by enhancing angiogenesis in disease conditions of reduced vascularity and blood flow, such as tissue ischemia, or alternatively to inhibit excessive and abnormal angiogenesis in disorders like cancer. Gold nanoparticles (AuNPs) are special particles that are generated by nanotechnology and composed of an inorganic core containing gold which is encircled by an organic monolayer. The ability of AuNPs to alter vasculature has captured recent attention in medical literature as potential therapeutic agents for the management of pathologic angiogenesis. This review provides an overview of the effects of AuNPs on angiogenesis and the molecular mechanisms and biomedical applications associated with their effects. In addition, the main synthesis methods, physical properties, uptake mechanisms, and toxicity of AuNPs are briefly summarized.Keywords: gold nanoparticles, angiogenesis, molecular signaling, VEGF, uptake, toxicity
format	article
author	Darweesh RS Ayoub NM Nazzal S
author_facet	Darweesh RS Ayoub NM Nazzal S
author_sort	Darweesh RS
title	Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications
title_short	Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications
title_full	Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications
title_fullStr	Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications
title_full_unstemmed	Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications
title_sort	gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/244d1eb211c847469b5490358a901142
work_keys_str_mv	AT darweeshrs goldnanoparticlesandangiogenesismolecularmechanismsandbiomedicalapplications AT ayoubnm goldnanoparticlesandangiogenesismolecularmechanismsandbiomedicalapplications AT nazzals goldnanoparticlesandangiogenesismolecularmechanismsandbiomedicalapplications
_version_	1718402515304710144

Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications

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