Severe apathy due to injury of prefronto-caudate tract

The caudate nucleus, which is vulnerable to hypoxic–ischemic brain injury (HI-BI), is important to cognitive function because it is connected to the prefrontal cortex. Using diffusion tensor tractography (DTT), no study on injury of the prefronto-caudate tract in a patient with HI-BI has been report...

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Autores principales:	Ho Jang Sung, Gyu Kwon Hyeok
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2019
Materias:	apathy prefrontal cortex caudate nucleus hypoxic–ischemic brain injury diffusion tensor tractography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/244df9f33ef143b2804fe76bee422a12
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spelling	oai:doaj.org-article:244df9f33ef143b2804fe76bee422a122021-12-05T14:11:04ZSevere apathy due to injury of prefronto-caudate tract2081-693610.1515/tnsci-2019-0027https://doaj.org/article/244df9f33ef143b2804fe76bee422a122019-07-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2019-0027https://doaj.org/toc/2081-6936The caudate nucleus, which is vulnerable to hypoxic–ischemic brain injury (HI-BI), is important to cognitive function because it is connected to the prefrontal cortex. Using diffusion tensor tractography (DTT), no study on injury of the prefronto-caudate tract in a patient with HI-BI has been reported so far. Here, we report a patient with severe apathy who showed injury of the prefronto-caudate tract following HI-BI, which was demonstrated by DTT. A 38-year-old female patient suffered HI-BI induced by carbon monoxide poisoning following attempted suicide for a period of approximately four hours. From the onset, the patient showed severe apathy (7 months after onset-the Apathy Scale score was 24 [full score: 42]). Brain MR images taken at seven months after onset showed no abnormality. On 7-month DTT, the neural connectivity of the caudate nucleus to the medial prefrontal cortex (Brodmann area: 10 and 12) and orbitofrontal cortex (Brodmann area: 11 and 13) was decreased in both hemispheres. Using DTT, injury of the prefronto-caudate tract was demonstrated in a patient who showed severe apathy following HI-BI. We believe that injury of the prefronto-caudate tract might be a pathogenetic mechanism of apathy in patients with HI-BI.Ho Jang SungGyu Kwon HyeokDe Gruyterarticleapathyprefrontal cortexcaudate nucleushypoxic–ischemic brain injurydiffusion tensor tractographyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 10, Iss 1, Pp 157-159 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	apathy prefrontal cortex caudate nucleus hypoxic–ischemic brain injury diffusion tensor tractography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	apathy prefrontal cortex caudate nucleus hypoxic–ischemic brain injury diffusion tensor tractography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ho Jang Sung Gyu Kwon Hyeok Severe apathy due to injury of prefronto-caudate tract
description	The caudate nucleus, which is vulnerable to hypoxic–ischemic brain injury (HI-BI), is important to cognitive function because it is connected to the prefrontal cortex. Using diffusion tensor tractography (DTT), no study on injury of the prefronto-caudate tract in a patient with HI-BI has been reported so far. Here, we report a patient with severe apathy who showed injury of the prefronto-caudate tract following HI-BI, which was demonstrated by DTT. A 38-year-old female patient suffered HI-BI induced by carbon monoxide poisoning following attempted suicide for a period of approximately four hours. From the onset, the patient showed severe apathy (7 months after onset-the Apathy Scale score was 24 [full score: 42]). Brain MR images taken at seven months after onset showed no abnormality. On 7-month DTT, the neural connectivity of the caudate nucleus to the medial prefrontal cortex (Brodmann area: 10 and 12) and orbitofrontal cortex (Brodmann area: 11 and 13) was decreased in both hemispheres. Using DTT, injury of the prefronto-caudate tract was demonstrated in a patient who showed severe apathy following HI-BI. We believe that injury of the prefronto-caudate tract might be a pathogenetic mechanism of apathy in patients with HI-BI.
format	article
author	Ho Jang Sung Gyu Kwon Hyeok
author_facet	Ho Jang Sung Gyu Kwon Hyeok
author_sort	Ho Jang Sung
title	Severe apathy due to injury of prefronto-caudate tract
title_short	Severe apathy due to injury of prefronto-caudate tract
title_full	Severe apathy due to injury of prefronto-caudate tract
title_fullStr	Severe apathy due to injury of prefronto-caudate tract
title_full_unstemmed	Severe apathy due to injury of prefronto-caudate tract
title_sort	severe apathy due to injury of prefronto-caudate tract
publisher	De Gruyter
publishDate	2019
url	https://doaj.org/article/244df9f33ef143b2804fe76bee422a12
work_keys_str_mv	AT hojangsung severeapathyduetoinjuryofprefrontocaudatetract AT gyukwonhyeok severeapathyduetoinjuryofprefrontocaudatetract
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Severe apathy due to injury of prefronto-caudate tract

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