The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress

The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress

Abstract Upon endoplasmic-reticulum (ER) stress, the ER-located transmembrane protein, Ire1, is autophosphorylated and acts as an endoribonuclease to trigger the unfolded protein response (UPR). Previous biochemical studies have shown that Ire1 exhibits strong endoribonuclease activity when its cyto...

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Autores principales: Quynh Giang Le, Yuki Ishiwata-Kimata, Thi Huong Phuong, Shigeto Fukunaka, Kenji Kohno, Yukio Kimata
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/244f0bfeceb04e76b0aedb99335c2c9a
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