Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes

Abstract We aimed to investigate the cell density and morphology of the corneal endothelium in ophthalmologically healthy young Japanese, given the lack of normative data in literature. This observational study included eyes without ophthalmologic diseases, besides refractive errors, examined betwee...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takashi Ono, Yosai Mori, Ryohei Nejima, Takuya Iwasaki, Takashi Miyai, Kazunori Miyata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2450f7dc228748f49c0fb72f2ec47f82
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2450f7dc228748f49c0fb72f2ec47f82
record_format	dspace
spelling	oai:doaj.org-article:2450f7dc228748f49c0fb72f2ec47f822021-12-02T18:02:06ZCorneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes10.1038/s41598-021-97776-52045-2322https://doaj.org/article/2450f7dc228748f49c0fb72f2ec47f822021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97776-5https://doaj.org/toc/2045-2322Abstract We aimed to investigate the cell density and morphology of the corneal endothelium in ophthalmologically healthy young Japanese, given the lack of normative data in literature. This observational study included eyes without ophthalmologic diseases, besides refractive errors, examined between 1996 and 2015 at Miyata Eye Hospital. Eyes with a history of ophthalmologic diseases or contact lens usage were excluded. Correlation of corneal endothelial cell density (ECD), coefficient of variation (CV), appearance rate of hexagonal cells (6A), and cell area with age were examined. Multivariate linear regression analysis was performed to determine the predictors of corneal parameters. We included 16842 eyes of 8421 individuals (19.6 ± 8.7 years). ECD was 3109.0 ± 303.7 cells/mm2 and significantly reduced with age (p < 0.001). The ECD reduction rate was 0.42%/year in the total population. On multivariate analysis, age and sex were significantly correlated with ECD, CV, 6A, and cell area (all p < 0.001). ECD, 6A, CV, and cell area are significantly associated with age in healthy young Japanese individuals. Monitoring their corneal endothelium is essential to assess the risk of endothelial damage.Takashi OnoYosai MoriRyohei NejimaTakuya IwasakiTakashi MiyaiKazunori MiyataNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takashi Ono Yosai Mori Ryohei Nejima Takuya Iwasaki Takashi Miyai Kazunori Miyata Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes
description	Abstract We aimed to investigate the cell density and morphology of the corneal endothelium in ophthalmologically healthy young Japanese, given the lack of normative data in literature. This observational study included eyes without ophthalmologic diseases, besides refractive errors, examined between 1996 and 2015 at Miyata Eye Hospital. Eyes with a history of ophthalmologic diseases or contact lens usage were excluded. Correlation of corneal endothelial cell density (ECD), coefficient of variation (CV), appearance rate of hexagonal cells (6A), and cell area with age were examined. Multivariate linear regression analysis was performed to determine the predictors of corneal parameters. We included 16842 eyes of 8421 individuals (19.6 ± 8.7 years). ECD was 3109.0 ± 303.7 cells/mm2 and significantly reduced with age (p < 0.001). The ECD reduction rate was 0.42%/year in the total population. On multivariate analysis, age and sex were significantly correlated with ECD, CV, 6A, and cell area (all p < 0.001). ECD, 6A, CV, and cell area are significantly associated with age in healthy young Japanese individuals. Monitoring their corneal endothelium is essential to assess the risk of endothelial damage.
format	article
author	Takashi Ono Yosai Mori Ryohei Nejima Takuya Iwasaki Takashi Miyai Kazunori Miyata
author_facet	Takashi Ono Yosai Mori Ryohei Nejima Takuya Iwasaki Takashi Miyai Kazunori Miyata
author_sort	Takashi Ono
title	Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes
title_short	Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes
title_full	Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes
title_fullStr	Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes
title_full_unstemmed	Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes
title_sort	corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in japan: an observational study of 16842 eyes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2450f7dc228748f49c0fb72f2ec47f82
work_keys_str_mv	AT takashiono cornealendothelialcelldensityandmorphologyinophthalmologicallyhealthyyoungindividualsinjapananobservationalstudyof16842eyes AT yosaimori cornealendothelialcelldensityandmorphologyinophthalmologicallyhealthyyoungindividualsinjapananobservationalstudyof16842eyes AT ryoheinejima cornealendothelialcelldensityandmorphologyinophthalmologicallyhealthyyoungindividualsinjapananobservationalstudyof16842eyes AT takuyaiwasaki cornealendothelialcelldensityandmorphologyinophthalmologicallyhealthyyoungindividualsinjapananobservationalstudyof16842eyes AT takashimiyai cornealendothelialcelldensityandmorphologyinophthalmologicallyhealthyyoungindividualsinjapananobservationalstudyof16842eyes AT kazunorimiyata cornealendothelialcelldensityandmorphologyinophthalmologicallyhealthyyoungindividualsinjapananobservationalstudyof16842eyes
_version_	1718378915500654592

Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes

Ejemplares similares