Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

Viruses are promising anti-tumour therapeutics due to induction of an immune response and/or oncolytic activity. Here, Kalkavanet al. show that LCMV replicates in tumour cells, without inducing cell lysis, and that its anti-tumour activity is largely mediated by recruitment of interferon-producing m...

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Autores principales:	Halime Kalkavan, Piyush Sharma, Stefan Kasper, Iris Helfrich, Aleksandra A. Pandyra, Asmae Gassa, Isabel Virchow, Lukas Flatz, Tim Brandenburg, Sukumar Namineni, Mathias Heikenwalder, Bastian Höchst, Percy A. Knolle, Guido Wollmann, Dorothee von Laer, Ingo Drexler, Jessica Rathbun, Paula M. Cannon, Stefanie Scheu, Jens Bauer, Jagat Chauhan, Dieter Häussinger, Gerald Willimsky, Max Löhning, Dirk Schadendorf, Sven Brandau, Martin Schuler, Philipp A. Lang, Karl S. Lang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2452e9d8f1cb48cd9071ab5ededf8f25
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spelling	oai:doaj.org-article:2452e9d8f1cb48cd9071ab5ededf8f252021-12-02T17:06:10ZSpatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression10.1038/ncomms144472041-1723https://doaj.org/article/2452e9d8f1cb48cd9071ab5ededf8f252017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14447https://doaj.org/toc/2041-1723Viruses are promising anti-tumour therapeutics due to induction of an immune response and/or oncolytic activity. Here, Kalkavanet al. show that LCMV replicates in tumour cells, without inducing cell lysis, and that its anti-tumour activity is largely mediated by recruitment of interferon-producing monocytes.Halime KalkavanPiyush SharmaStefan KasperIris HelfrichAleksandra A. PandyraAsmae GassaIsabel VirchowLukas FlatzTim BrandenburgSukumar NamineniMathias HeikenwalderBastian HöchstPercy A. KnolleGuido WollmannDorothee von LaerIngo DrexlerJessica RathbunPaula M. CannonStefanie ScheuJens BauerJagat ChauhanDieter HäussingerGerald WillimskyMax LöhningDirk SchadendorfSven BrandauMartin SchulerPhilipp A. LangKarl S. LangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Halime Kalkavan Piyush Sharma Stefan Kasper Iris Helfrich Aleksandra A. Pandyra Asmae Gassa Isabel Virchow Lukas Flatz Tim Brandenburg Sukumar Namineni Mathias Heikenwalder Bastian Höchst Percy A. Knolle Guido Wollmann Dorothee von Laer Ingo Drexler Jessica Rathbun Paula M. Cannon Stefanie Scheu Jens Bauer Jagat Chauhan Dieter Häussinger Gerald Willimsky Max Löhning Dirk Schadendorf Sven Brandau Martin Schuler Philipp A. Lang Karl S. Lang Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
description	Viruses are promising anti-tumour therapeutics due to induction of an immune response and/or oncolytic activity. Here, Kalkavanet al. show that LCMV replicates in tumour cells, without inducing cell lysis, and that its anti-tumour activity is largely mediated by recruitment of interferon-producing monocytes.
format	article
author	Halime Kalkavan Piyush Sharma Stefan Kasper Iris Helfrich Aleksandra A. Pandyra Asmae Gassa Isabel Virchow Lukas Flatz Tim Brandenburg Sukumar Namineni Mathias Heikenwalder Bastian Höchst Percy A. Knolle Guido Wollmann Dorothee von Laer Ingo Drexler Jessica Rathbun Paula M. Cannon Stefanie Scheu Jens Bauer Jagat Chauhan Dieter Häussinger Gerald Willimsky Max Löhning Dirk Schadendorf Sven Brandau Martin Schuler Philipp A. Lang Karl S. Lang
author_facet	Halime Kalkavan Piyush Sharma Stefan Kasper Iris Helfrich Aleksandra A. Pandyra Asmae Gassa Isabel Virchow Lukas Flatz Tim Brandenburg Sukumar Namineni Mathias Heikenwalder Bastian Höchst Percy A. Knolle Guido Wollmann Dorothee von Laer Ingo Drexler Jessica Rathbun Paula M. Cannon Stefanie Scheu Jens Bauer Jagat Chauhan Dieter Häussinger Gerald Willimsky Max Löhning Dirk Schadendorf Sven Brandau Martin Schuler Philipp A. Lang Karl S. Lang
author_sort	Halime Kalkavan
title	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_short	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_full	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_fullStr	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_full_unstemmed	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_sort	spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2452e9d8f1cb48cd9071ab5ededf8f25
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Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

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