Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies

Carla Caffarelli,1 Andrea Montagnani,2 Ranuccio Nuti,1 Stefano Gonnelli1 1Department of Medicine, Surgery and Neuroscience, University of Siena, Italy; 2Division of Internal Medicine, General Hospital Misericordia, Grosseto, Italy Background: Epidemiologic and clinical data have suggested the exis...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Caffarelli C, Montagnani A, Nuti R, Gonnelli S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	biphosphonates atherosclerosis vascular calcification human studies Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/2453ce3962de4aeebda02197a5568172
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2453ce3962de4aeebda02197a5568172
record_format	dspace
spelling	oai:doaj.org-article:2453ce3962de4aeebda02197a55681722021-12-02T02:46:10ZBisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies1178-1998https://doaj.org/article/2453ce3962de4aeebda02197a55681722017-10-01T00:00:00Zhttps://www.dovepress.com/bisphosphonates-atherosclerosis-and-vascular-calcification-update-and--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Carla Caffarelli,1 Andrea Montagnani,2 Ranuccio Nuti,1 Stefano Gonnelli1 1Department of Medicine, Surgery and Neuroscience, University of Siena, Italy; 2Division of Internal Medicine, General Hospital Misericordia, Grosseto, Italy Background: Epidemiologic and clinical data have suggested the existence of a biologic linkage between the bone system and the vascular system. Bisphosphonates (BPs) are effective inhibitors of bone resorption and are currently considered the drugs of choice for the prevention and treatment of osteoporosis and related fractures. Data from several publications have suggested that BPs may also be effective in reducing the atherosclerotic process and vascular calcification, but the results of these studies are contrasting. This review aimed to allow a better understanding of the relationships between BPs and atherosclerosis in humans.Materials and methods: Electronic databases of Pubmed-Medline, Cochrane Library and SCOPUS from inception to June 30, 2016 were searched. The full texts of the articles potentially eligible were carefully assessed and reviewed. Finally, 20 studies were found to be eligible and were included in the systematic review. All included studies were published between 2000 and 2014.Results: In several studies, etidronate limited the progression of aortic and coronary calcification in hemodialysis patients, whereas the nitrogen-containing-BPs given orally did not significantly reduce vascular calcifications in patients with chronic kidney disease, kidney trasplant or in those with osteoporosis. Nitrogen-containing-BPs present favorable effects both on vessel wall thickness and on arterial elasticity due to both a reduction in serum lipids and the interaction of BPs with the bone tissue, with the consequent release of bone turnover markers and cytokines into the bloodstream.Conclusion: To sum up, the BPs seem to have the potential of influencing atherosclerosis and calcium homeostasis at the level of vascular walls with several possible mechanisms which may differ according to the type, potency, dosage and administration route of BPs. Additional studies are needed to specifically address the mechanism by which BP use could influence cardiovascular morbidity and mortality. Keywords: bisphosphonates, atherosclerosis, vascular calcification, human studiesCaffarelli CMontagnani ANuti RGonnelli SDove Medical Pressarticlebiphosphonatesatherosclerosisvascular calcificationhuman studiesGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1819-1828 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	biphosphonates atherosclerosis vascular calcification human studies Geriatrics RC952-954.6
spellingShingle	biphosphonates atherosclerosis vascular calcification human studies Geriatrics RC952-954.6 Caffarelli C Montagnani A Nuti R Gonnelli S Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies
description	Carla Caffarelli,1 Andrea Montagnani,2 Ranuccio Nuti,1 Stefano Gonnelli1 1Department of Medicine, Surgery and Neuroscience, University of Siena, Italy; 2Division of Internal Medicine, General Hospital Misericordia, Grosseto, Italy Background: Epidemiologic and clinical data have suggested the existence of a biologic linkage between the bone system and the vascular system. Bisphosphonates (BPs) are effective inhibitors of bone resorption and are currently considered the drugs of choice for the prevention and treatment of osteoporosis and related fractures. Data from several publications have suggested that BPs may also be effective in reducing the atherosclerotic process and vascular calcification, but the results of these studies are contrasting. This review aimed to allow a better understanding of the relationships between BPs and atherosclerosis in humans.Materials and methods: Electronic databases of Pubmed-Medline, Cochrane Library and SCOPUS from inception to June 30, 2016 were searched. The full texts of the articles potentially eligible were carefully assessed and reviewed. Finally, 20 studies were found to be eligible and were included in the systematic review. All included studies were published between 2000 and 2014.Results: In several studies, etidronate limited the progression of aortic and coronary calcification in hemodialysis patients, whereas the nitrogen-containing-BPs given orally did not significantly reduce vascular calcifications in patients with chronic kidney disease, kidney trasplant or in those with osteoporosis. Nitrogen-containing-BPs present favorable effects both on vessel wall thickness and on arterial elasticity due to both a reduction in serum lipids and the interaction of BPs with the bone tissue, with the consequent release of bone turnover markers and cytokines into the bloodstream.Conclusion: To sum up, the BPs seem to have the potential of influencing atherosclerosis and calcium homeostasis at the level of vascular walls with several possible mechanisms which may differ according to the type, potency, dosage and administration route of BPs. Additional studies are needed to specifically address the mechanism by which BP use could influence cardiovascular morbidity and mortality. Keywords: bisphosphonates, atherosclerosis, vascular calcification, human studies
format	article
author	Caffarelli C Montagnani A Nuti R Gonnelli S
author_facet	Caffarelli C Montagnani A Nuti R Gonnelli S
author_sort	Caffarelli C
title	Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies
title_short	Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies
title_full	Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies
title_fullStr	Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies
title_full_unstemmed	Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies
title_sort	bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/2453ce3962de4aeebda02197a5568172
work_keys_str_mv	AT caffarellic bisphosphonatesatherosclerosisandvascularcalcificationupdateandsystematicreviewofclinicalstudies AT montagnania bisphosphonatesatherosclerosisandvascularcalcificationupdateandsystematicreviewofclinicalstudies AT nutir bisphosphonatesatherosclerosisandvascularcalcificationupdateandsystematicreviewofclinicalstudies AT gonnellis bisphosphonatesatherosclerosisandvascularcalcificationupdateandsystematicreviewofclinicalstudies
_version_	1718402149593907200

Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies

Ejemplares similares