Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density

Rongtao Cui,1 Lin Zhou,2 Zuohong Li,2 Qing Li,2 Zhiming Qi,2 Junyong Zhang3 1Department of Orthopedic and Trauma Surgery, Surgical Research, Duisburg-Essen University Hospital, Essen, Germany; 2Department of Orthopedics, Dalian Central Hospital, Dalian, 3Department of Gastroenterology, Shandong Pro...

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Autores principales:	Cui RT, Zhou L, Li ZH, Li Q, Qi ZM, Zhang JY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	age body mass index blood glucose serum lipid profiles bone mineral density osteoporosis Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/2455748d3ad84d11824fb0c69b6ee20f
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spelling	oai:doaj.org-article:2455748d3ad84d11824fb0c69b6ee20f2021-12-02T00:23:26ZAssessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density1178-1998https://doaj.org/article/2455748d3ad84d11824fb0c69b6ee20f2016-07-01T00:00:00Zhttps://www.dovepress.com/assessment-risk-of-osteoporosis-in-chinese-people-relationship-among-b-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Rongtao Cui,1 Lin Zhou,2 Zuohong Li,2 Qing Li,2 Zhiming Qi,2 Junyong Zhang3 1Department of Orthopedic and Trauma Surgery, Surgical Research, Duisburg-Essen University Hospital, Essen, Germany; 2Department of Orthopedics, Dalian Central Hospital, Dalian, 3Department of Gastroenterology, Shandong Provincial Hospital, Jinan, People’s Republic of China Objective: The aim of our study was to investigate the relationship among age, sex, body mass index (BMI), serum lipid profiles, blood glucose (BG), and bone mineral density (BMD), making an assessment of the risk of osteoporosis.Materials and methods: A total of 1,035 male and 3,953 female healthy volunteers (aged 41–95 years) were recruited by an open invitation. The basic information, including age, sex, height, weight, waistline, hipline, menstrual cycle, and medical history, were collected by a questionnaire survey and physical examination. Serum lipid profiles, BG, postprandial blood glucose, and glycosylated hemoglobin were obtained after 12 hours fasting. BMD in lumbar spine was measured by dual-energy X-ray absorptiometry scanning.Results: The age-adjusted BMD in females was significantly lower than in males. With aging, greater differences of BMD distribution exist in elderly females than in males (P<0.001), and the fastigium of bone mass loss was in the age range from 51 to 55 in females and from 61 to 65 years in males. After adjustment for sex, there were significant differences in BMD among BMI-stratified groups in both males and females. The subjects with a BMI of <18.5 had a higher incidence of osteoporosis than BMI ≥18.5 in both sexes. BMD in type 2 diabetes mellitus with a BG of >7.0 mmol/L was lower than in people with BG of ≤7.0 mmol/L (P<0.001). People with serum high-density lipoprotein cholesterol levels of ≥1.56 mmol/L had a greater prevalence of osteoporosis compared with high-density lipoprotein cholesterol ≤1.55 mmol/L. Logistic regression with odds ratios showed that no association was found among total cholesterol, triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin, postprandial blood glucose and BMD.Conclusion: The present study further confirmed that factors such as age, sex, weight, BMI, high-density lipoprotein cholesterol, and diabetes are significant predictors of osteoporosis in the Chinese people. Keywords: risk assessment, BMI, blood glucose, serum lipid profiles, osteoporosisCui RTZhou LLi ZHLi QQi ZMZhang JYDove Medical Pressarticleagebody mass indexblood glucoseserum lipid profilesbone mineral densityosteoporosisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 887-895 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	age body mass index blood glucose serum lipid profiles bone mineral density osteoporosis Geriatrics RC952-954.6
spellingShingle	age body mass index blood glucose serum lipid profiles bone mineral density osteoporosis Geriatrics RC952-954.6 Cui RT Zhou L Li ZH Li Q Qi ZM Zhang JY Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density
description	Rongtao Cui,1 Lin Zhou,2 Zuohong Li,2 Qing Li,2 Zhiming Qi,2 Junyong Zhang3 1Department of Orthopedic and Trauma Surgery, Surgical Research, Duisburg-Essen University Hospital, Essen, Germany; 2Department of Orthopedics, Dalian Central Hospital, Dalian, 3Department of Gastroenterology, Shandong Provincial Hospital, Jinan, People’s Republic of China Objective: The aim of our study was to investigate the relationship among age, sex, body mass index (BMI), serum lipid profiles, blood glucose (BG), and bone mineral density (BMD), making an assessment of the risk of osteoporosis.Materials and methods: A total of 1,035 male and 3,953 female healthy volunteers (aged 41–95 years) were recruited by an open invitation. The basic information, including age, sex, height, weight, waistline, hipline, menstrual cycle, and medical history, were collected by a questionnaire survey and physical examination. Serum lipid profiles, BG, postprandial blood glucose, and glycosylated hemoglobin were obtained after 12 hours fasting. BMD in lumbar spine was measured by dual-energy X-ray absorptiometry scanning.Results: The age-adjusted BMD in females was significantly lower than in males. With aging, greater differences of BMD distribution exist in elderly females than in males (P<0.001), and the fastigium of bone mass loss was in the age range from 51 to 55 in females and from 61 to 65 years in males. After adjustment for sex, there were significant differences in BMD among BMI-stratified groups in both males and females. The subjects with a BMI of <18.5 had a higher incidence of osteoporosis than BMI ≥18.5 in both sexes. BMD in type 2 diabetes mellitus with a BG of >7.0 mmol/L was lower than in people with BG of ≤7.0 mmol/L (P<0.001). People with serum high-density lipoprotein cholesterol levels of ≥1.56 mmol/L had a greater prevalence of osteoporosis compared with high-density lipoprotein cholesterol ≤1.55 mmol/L. Logistic regression with odds ratios showed that no association was found among total cholesterol, triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin, postprandial blood glucose and BMD.Conclusion: The present study further confirmed that factors such as age, sex, weight, BMI, high-density lipoprotein cholesterol, and diabetes are significant predictors of osteoporosis in the Chinese people. Keywords: risk assessment, BMI, blood glucose, serum lipid profiles, osteoporosis
format	article
author	Cui RT Zhou L Li ZH Li Q Qi ZM Zhang JY
author_facet	Cui RT Zhou L Li ZH Li Q Qi ZM Zhang JY
author_sort	Cui RT
title	Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density
title_short	Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density
title_full	Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density
title_fullStr	Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density
title_full_unstemmed	Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density
title_sort	assessment risk of osteoporosis in chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/2455748d3ad84d11824fb0c69b6ee20f
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Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density

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