Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells, which is especially uncommon in the minor salivary glands (MSG). Because of its histologic variety...

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Autores principales:	Kohei Okuyama, Yasuyuki Michi, Yoshihisa Kashima, Hirofumi Tomioka, Hideaki Hirai, Misaki Yokokawa, Yuko Yamagata, Takeshi Kuroshima, Yuriko Sato, Maiko Tsuchiya, Kou Kayamori, Tohru Ikeda, Hiroyuki Harada
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	epithelial-myoepithelial carcinoma minor salivary gland low-grade immunohistochemistry Ki-67 pleomorphic adenoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/245aa7e8cd9f450ba3e5d2f39703ffff
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spelling	oai:doaj.org-article:245aa7e8cd9f450ba3e5d2f39703ffff2021-11-25T17:21:49ZEpithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review10.3390/diagnostics111121242075-4418https://doaj.org/article/245aa7e8cd9f450ba3e5d2f39703ffff2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2124https://doaj.org/toc/2075-4418Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells, which is especially uncommon in the minor salivary glands (MSG). Because of its histologic variety, complexity, and heterogeneity, it is sometimes challenging to make the accurate diagnosis. Here, we report a literature review of EMC of the MSGs with our experience of two cases. Incisional biopsy was suggestive of pleomorphic adenoma in Case 1 and pleomorphic adenoma or a low-grade salivary gland carcinoma in Case 2. Both cases were performed intraoral tumor resection, and they have good postoperative courses and are alive with no evidence of local recurrence or metastasis at 31 and 16 months, respectively. Considering that the anatomy, structure, and size of salivary glands are quite different from MSGs, it might be difficult to predict EMCs of the MSG similarly to EMCs of the major salivary glands. This comprehensive review also reports the features of EMC of the MSG cases and the trends of diagnosis and discusses treatment strategy.Kohei OkuyamaYasuyuki MichiYoshihisa KashimaHirofumi TomiokaHideaki HiraiMisaki YokokawaYuko YamagataTakeshi KuroshimaYuriko SatoMaiko TsuchiyaKou KayamoriTohru IkedaHiroyuki HaradaMDPI AGarticleepithelial-myoepithelial carcinomaminor salivary glandlow-gradeimmunohistochemistryKi-67pleomorphic adenomaMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2124, p 2124 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epithelial-myoepithelial carcinoma minor salivary gland low-grade immunohistochemistry Ki-67 pleomorphic adenoma Medicine (General) R5-920
spellingShingle	epithelial-myoepithelial carcinoma minor salivary gland low-grade immunohistochemistry Ki-67 pleomorphic adenoma Medicine (General) R5-920 Kohei Okuyama Yasuyuki Michi Yoshihisa Kashima Hirofumi Tomioka Hideaki Hirai Misaki Yokokawa Yuko Yamagata Takeshi Kuroshima Yuriko Sato Maiko Tsuchiya Kou Kayamori Tohru Ikeda Hiroyuki Harada Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review
description	Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells, which is especially uncommon in the minor salivary glands (MSG). Because of its histologic variety, complexity, and heterogeneity, it is sometimes challenging to make the accurate diagnosis. Here, we report a literature review of EMC of the MSGs with our experience of two cases. Incisional biopsy was suggestive of pleomorphic adenoma in Case 1 and pleomorphic adenoma or a low-grade salivary gland carcinoma in Case 2. Both cases were performed intraoral tumor resection, and they have good postoperative courses and are alive with no evidence of local recurrence or metastasis at 31 and 16 months, respectively. Considering that the anatomy, structure, and size of salivary glands are quite different from MSGs, it might be difficult to predict EMCs of the MSG similarly to EMCs of the major salivary glands. This comprehensive review also reports the features of EMC of the MSG cases and the trends of diagnosis and discusses treatment strategy.
format	article
author	Kohei Okuyama Yasuyuki Michi Yoshihisa Kashima Hirofumi Tomioka Hideaki Hirai Misaki Yokokawa Yuko Yamagata Takeshi Kuroshima Yuriko Sato Maiko Tsuchiya Kou Kayamori Tohru Ikeda Hiroyuki Harada
author_facet	Kohei Okuyama Yasuyuki Michi Yoshihisa Kashima Hirofumi Tomioka Hideaki Hirai Misaki Yokokawa Yuko Yamagata Takeshi Kuroshima Yuriko Sato Maiko Tsuchiya Kou Kayamori Tohru Ikeda Hiroyuki Harada
author_sort	Kohei Okuyama
title	Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review
title_short	Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review
title_full	Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review
title_fullStr	Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review
title_full_unstemmed	Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review
title_sort	epithelial-myoepithelial carcinoma of the minor salivary glands: case series with comprehensive review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/245aa7e8cd9f450ba3e5d2f39703ffff
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Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review

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