Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease

The health benefits of bovine colostrum have extensively been studied, including immune effects mediated by immunoglobulins, lactoferrin, and casein, as well as by certain growth factors. Some of these effects are not directly related to the absorption of proteins from the intestinal tract. The inge...

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Autores principales:	Subrata Ghosh, Marietta Iacucci
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	immune effects bovine colostrum infections Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/245b6882252d4c538dd0d1efbafec8db
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spelling	oai:doaj.org-article:245b6882252d4c538dd0d1efbafec8db2021-11-25T18:34:11ZDiverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease10.3390/nu131137982072-6643https://doaj.org/article/245b6882252d4c538dd0d1efbafec8db2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3798https://doaj.org/toc/2072-6643The health benefits of bovine colostrum have extensively been studied, including immune effects mediated by immunoglobulins, lactoferrin, and casein, as well as by certain growth factors. Some of these effects are not directly related to the absorption of proteins from the intestinal tract. The ingestion of BC can modulate the function of subsets of lymphocytes, macrophages, and dendritic cells and increase regulatory cytokines such as interleukin 10. In this review, we predominantly focused on evidence from human studies on benefits in health and disease. This review highlights that clear evidence of the prevention of infectious diseases in pre-term infants such as necrotizing enterocolitis, neonatal sepsis or prevention of cancer metastasis is lacking. This is clearly an area where translational science has to be strengthened, taking the considerable evidence from numerous ex vivo studies on cells and tissues and from animal interventions. The review focuses predominantly on human data.Subrata GhoshMarietta IacucciMDPI AGarticleimmune effectsbovine colostruminfectionsNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3798, p 3798 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immune effects bovine colostrum infections Nutrition. Foods and food supply TX341-641
spellingShingle	immune effects bovine colostrum infections Nutrition. Foods and food supply TX341-641 Subrata Ghosh Marietta Iacucci Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease
description	The health benefits of bovine colostrum have extensively been studied, including immune effects mediated by immunoglobulins, lactoferrin, and casein, as well as by certain growth factors. Some of these effects are not directly related to the absorption of proteins from the intestinal tract. The ingestion of BC can modulate the function of subsets of lymphocytes, macrophages, and dendritic cells and increase regulatory cytokines such as interleukin 10. In this review, we predominantly focused on evidence from human studies on benefits in health and disease. This review highlights that clear evidence of the prevention of infectious diseases in pre-term infants such as necrotizing enterocolitis, neonatal sepsis or prevention of cancer metastasis is lacking. This is clearly an area where translational science has to be strengthened, taking the considerable evidence from numerous ex vivo studies on cells and tissues and from animal interventions. The review focuses predominantly on human data.
format	article
author	Subrata Ghosh Marietta Iacucci
author_facet	Subrata Ghosh Marietta Iacucci
author_sort	Subrata Ghosh
title	Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease
title_short	Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease
title_full	Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease
title_fullStr	Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease
title_full_unstemmed	Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease
title_sort	diverse immune effects of bovine colostrum and benefits in human health and disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/245b6882252d4c538dd0d1efbafec8db
work_keys_str_mv	AT subrataghosh diverseimmuneeffectsofbovinecolostrumandbenefitsinhumanhealthanddisease AT mariettaiacucci diverseimmuneeffectsofbovinecolostrumandbenefitsinhumanhealthanddisease
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Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease

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