Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole

Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole

Chirag G Patel, Li Li, Suzette Girgis, David M Kornhauser, Ernest U Frevert, David W BoultonBristol-Myers Squibb, Princeton, NJ, USABackground: Many medicines, including several cholesterol-lowering agents (eg, lovastatin, simvastatin), antihypertensives (eg, diltiazem, nifedipine, verapamil), and a...

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Autores principales: Patel C, Li L, Girgis S, Kornhauser D, Frevert E, Boulton D
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2011
Materias:
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/245b79bc6e874bf6a7d03ee071325afe
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