Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine

ABSTRACT In modern-day vaccine design, a good pneumococcal capsular polysaccharide vaccine is measured by its ability to induce opsonic antibodies. These antibodies label bacteria for phagocytosis by neutrophils and thereby overcome the capsule’s barrier function. Doyle and Pirofski have raised a se...

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Autores principales:	Julia L. Hurwitz, Elaine Tuomanen
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/245be4cdc415405d92b5e501338b621a
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spelling	oai:doaj.org-article:245be4cdc415405d92b5e501338b621a2021-11-15T15:49:40ZUnveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine10.1128/mBio.00137-162150-7511https://doaj.org/article/245be4cdc415405d92b5e501338b621a2016-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00137-16https://doaj.org/toc/2150-7511ABSTRACT In modern-day vaccine design, a good pneumococcal capsular polysaccharide vaccine is measured by its ability to induce opsonic antibodies. These antibodies label bacteria for phagocytosis by neutrophils and thereby overcome the capsule’s barrier function. Doyle and Pirofski have raised a serious challenge to the current paradigm by describing anti-capsular antibodies that are highly protective but nonopsonic [C.R. Doyle and L. Pirofski, mBio 7(1):e02260-15, 2016, doi:10.1128/mBio.02260-15]. In fact, some functions are not related to neutrophils or phagocytosis at all. An increased awareness of these activities is critical not only for accurate comparisons of vaccine candidates but also for improvements in vaccination outcomes in settings of neutropenia. When vaccine developers select a single gatekeeper assay (e.g., an opsonophagocytic assay for bacteria or a neutralization assay for viruses), promising vaccine candidates may be missed. Doyle and Pirofski stress that multiple functions, not just one, should be investigated to enhance discovery of antibody mechanisms and to best assess vaccine-induced correlates of immune protection.Julia L. HurwitzElaine TuomanenAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 1 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Julia L. Hurwitz Elaine Tuomanen Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine
description	ABSTRACT In modern-day vaccine design, a good pneumococcal capsular polysaccharide vaccine is measured by its ability to induce opsonic antibodies. These antibodies label bacteria for phagocytosis by neutrophils and thereby overcome the capsule’s barrier function. Doyle and Pirofski have raised a serious challenge to the current paradigm by describing anti-capsular antibodies that are highly protective but nonopsonic [C.R. Doyle and L. Pirofski, mBio 7(1):e02260-15, 2016, doi:10.1128/mBio.02260-15]. In fact, some functions are not related to neutrophils or phagocytosis at all. An increased awareness of these activities is critical not only for accurate comparisons of vaccine candidates but also for improvements in vaccination outcomes in settings of neutropenia. When vaccine developers select a single gatekeeper assay (e.g., an opsonophagocytic assay for bacteria or a neutralization assay for viruses), promising vaccine candidates may be missed. Doyle and Pirofski stress that multiple functions, not just one, should be investigated to enhance discovery of antibody mechanisms and to best assess vaccine-induced correlates of immune protection.
format	article
author	Julia L. Hurwitz Elaine Tuomanen
author_facet	Julia L. Hurwitz Elaine Tuomanen
author_sort	Julia L. Hurwitz
title	Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine
title_short	Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine
title_full	Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine
title_fullStr	Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine
title_full_unstemmed	Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine
title_sort	unveiling unexpected immune activities induced by your pneumococcal vaccine
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/245be4cdc415405d92b5e501338b621a
work_keys_str_mv	AT julialhurwitz unveilingunexpectedimmuneactivitiesinducedbyyourpneumococcalvaccine AT elainetuomanen unveilingunexpectedimmuneactivitiesinducedbyyourpneumococcalvaccine
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Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine

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