Adaptation to dietary conditions by trehalose metabolism in Drosophila

Abstract Trehalose is a non-reducing disaccharide that serves as the main sugar component of haemolymph in insects. Trehalose hydrolysis enzyme, called trehalase, is highly conserved from bacteria to humans. However, our understanding of the physiological role of trehalase remains incomplete. Here,...

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Autores principales:	Tetsuo Yasugi, Takayuki Yamada, Takashi Nishimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24646667135c45cda8f3670ef2d98fbc
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spelling	oai:doaj.org-article:24646667135c45cda8f3670ef2d98fbc2021-12-02T11:53:00ZAdaptation to dietary conditions by trehalose metabolism in Drosophila10.1038/s41598-017-01754-92045-2322https://doaj.org/article/24646667135c45cda8f3670ef2d98fbc2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01754-9https://doaj.org/toc/2045-2322Abstract Trehalose is a non-reducing disaccharide that serves as the main sugar component of haemolymph in insects. Trehalose hydrolysis enzyme, called trehalase, is highly conserved from bacteria to humans. However, our understanding of the physiological role of trehalase remains incomplete. Here, we analyze the phenotypes of several Trehalase (Treh) loss-of-function alleles in a comparative manner in Drosophila. The previously reported mutant phenotype of Treh affecting neuroepithelial stem cell maintenance and differentiation in the optic lobe is caused by second-site alleles in addition to Treh. We further report that the survival rate of Treh null mutants is significantly influenced by dietary conditions. Treh mutant larvae are lethal not only on a low-sugar diet but also under low-protein diet conditions. A reduction in adaptation ability under poor food conditions in Treh mutants is mainly caused by the overaccumulation of trehalose rather than the loss of Treh, because the additional loss of Tps1 mitigates the lethal effect of Treh mutants. These results demonstrate that proper trehalose metabolism plays a critical role in adaptation under various environmental conditions.Tetsuo YasugiTakayuki YamadaTakashi NishimuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tetsuo Yasugi Takayuki Yamada Takashi Nishimura Adaptation to dietary conditions by trehalose metabolism in Drosophila
description	Abstract Trehalose is a non-reducing disaccharide that serves as the main sugar component of haemolymph in insects. Trehalose hydrolysis enzyme, called trehalase, is highly conserved from bacteria to humans. However, our understanding of the physiological role of trehalase remains incomplete. Here, we analyze the phenotypes of several Trehalase (Treh) loss-of-function alleles in a comparative manner in Drosophila. The previously reported mutant phenotype of Treh affecting neuroepithelial stem cell maintenance and differentiation in the optic lobe is caused by second-site alleles in addition to Treh. We further report that the survival rate of Treh null mutants is significantly influenced by dietary conditions. Treh mutant larvae are lethal not only on a low-sugar diet but also under low-protein diet conditions. A reduction in adaptation ability under poor food conditions in Treh mutants is mainly caused by the overaccumulation of trehalose rather than the loss of Treh, because the additional loss of Tps1 mitigates the lethal effect of Treh mutants. These results demonstrate that proper trehalose metabolism plays a critical role in adaptation under various environmental conditions.
format	article
author	Tetsuo Yasugi Takayuki Yamada Takashi Nishimura
author_facet	Tetsuo Yasugi Takayuki Yamada Takashi Nishimura
author_sort	Tetsuo Yasugi
title	Adaptation to dietary conditions by trehalose metabolism in Drosophila
title_short	Adaptation to dietary conditions by trehalose metabolism in Drosophila
title_full	Adaptation to dietary conditions by trehalose metabolism in Drosophila
title_fullStr	Adaptation to dietary conditions by trehalose metabolism in Drosophila
title_full_unstemmed	Adaptation to dietary conditions by trehalose metabolism in Drosophila
title_sort	adaptation to dietary conditions by trehalose metabolism in drosophila
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/24646667135c45cda8f3670ef2d98fbc
work_keys_str_mv	AT tetsuoyasugi adaptationtodietaryconditionsbytrehalosemetabolismindrosophila AT takayukiyamada adaptationtodietaryconditionsbytrehalosemetabolismindrosophila AT takashinishimura adaptationtodietaryconditionsbytrehalosemetabolismindrosophila
_version_	1718394912765902848

Adaptation to dietary conditions by trehalose metabolism in Drosophila

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