Signatures of diversifying selection in European pig breeds.

Following domestication, livestock breeds have experienced intense selection pressures for the development of desirable traits. This has resulted in a large diversity of breeds that display variation in many phenotypic traits, such as coat colour, muscle composition, early maturity, growth rate, bod...

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Autores principales:	Samantha Wilkinson, Zen H Lu, Hendrik-Jan Megens, Alan L Archibald, Chris Haley, Ian J Jackson, Martien A M Groenen, Richard P M A Crooijmans, Rob Ogden, Pamela Wiener
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/24684a7970954a73b149eecc02d671a2
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spelling	oai:doaj.org-article:24684a7970954a73b149eecc02d671a22021-11-18T06:19:42ZSignatures of diversifying selection in European pig breeds.1553-73901553-740410.1371/journal.pgen.1003453https://doaj.org/article/24684a7970954a73b149eecc02d671a22013-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23637623/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Following domestication, livestock breeds have experienced intense selection pressures for the development of desirable traits. This has resulted in a large diversity of breeds that display variation in many phenotypic traits, such as coat colour, muscle composition, early maturity, growth rate, body size, reproduction, and behaviour. To better understand the relationship between genomic composition and phenotypic diversity arising from breed development, the genomes of 13 traditional and commercial European pig breeds were scanned for signatures of diversifying selection using the Porcine60K SNP chip, applying a between-population (differentiation) approach. Signatures of diversifying selection between breeds were found in genomic regions associated with traits related to breed standard criteria, such as coat colour and ear morphology. Amino acid differences in the EDNRB gene appear to be associated with one of these signatures, and variation in the KITLG gene may be associated with another. Other selection signals were found in genomic regions including QTLs and genes associated with production traits such as reproduction, growth, and fat deposition. Some selection signatures were associated with regions showing evidence of introgression from Asian breeds. When the European breeds were compared with wild boar, genomic regions with high levels of differentiation harboured genes related to bone formation, growth, and fat deposition.Samantha WilkinsonZen H LuHendrik-Jan MegensAlan L ArchibaldChris HaleyIan J JacksonMartien A M GroenenRichard P M A CrooijmansRob OgdenPamela WienerPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 9, Iss 4, p e1003453 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Samantha Wilkinson Zen H Lu Hendrik-Jan Megens Alan L Archibald Chris Haley Ian J Jackson Martien A M Groenen Richard P M A Crooijmans Rob Ogden Pamela Wiener Signatures of diversifying selection in European pig breeds.
description	Following domestication, livestock breeds have experienced intense selection pressures for the development of desirable traits. This has resulted in a large diversity of breeds that display variation in many phenotypic traits, such as coat colour, muscle composition, early maturity, growth rate, body size, reproduction, and behaviour. To better understand the relationship between genomic composition and phenotypic diversity arising from breed development, the genomes of 13 traditional and commercial European pig breeds were scanned for signatures of diversifying selection using the Porcine60K SNP chip, applying a between-population (differentiation) approach. Signatures of diversifying selection between breeds were found in genomic regions associated with traits related to breed standard criteria, such as coat colour and ear morphology. Amino acid differences in the EDNRB gene appear to be associated with one of these signatures, and variation in the KITLG gene may be associated with another. Other selection signals were found in genomic regions including QTLs and genes associated with production traits such as reproduction, growth, and fat deposition. Some selection signatures were associated with regions showing evidence of introgression from Asian breeds. When the European breeds were compared with wild boar, genomic regions with high levels of differentiation harboured genes related to bone formation, growth, and fat deposition.
format	article
author	Samantha Wilkinson Zen H Lu Hendrik-Jan Megens Alan L Archibald Chris Haley Ian J Jackson Martien A M Groenen Richard P M A Crooijmans Rob Ogden Pamela Wiener
author_facet	Samantha Wilkinson Zen H Lu Hendrik-Jan Megens Alan L Archibald Chris Haley Ian J Jackson Martien A M Groenen Richard P M A Crooijmans Rob Ogden Pamela Wiener
author_sort	Samantha Wilkinson
title	Signatures of diversifying selection in European pig breeds.
title_short	Signatures of diversifying selection in European pig breeds.
title_full	Signatures of diversifying selection in European pig breeds.
title_fullStr	Signatures of diversifying selection in European pig breeds.
title_full_unstemmed	Signatures of diversifying selection in European pig breeds.
title_sort	signatures of diversifying selection in european pig breeds.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/24684a7970954a73b149eecc02d671a2
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Signatures of diversifying selection in European pig breeds.

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