The interplay between Ras, Autophagy and cancer

Autophagy is an evolutionary conserved process of self-degradation and turnover of cellular components. The role of autophagy in human diseases is complexed as it can promote or inhibit disease progression. In cancer, autophagy can be detrimental or protective, depending on cellular contexts. Ras, a...

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Autores principales:	Eran Schmukler, Ronit Pinkas-Kramarski
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Ras Autophagy Cell signaling Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/246a4353ec46418e85dae627819ff69e
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id	oai:doaj.org-article:246a4353ec46418e85dae627819ff69e
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spelling	oai:doaj.org-article:246a4353ec46418e85dae627819ff69e2021-11-10T04:44:10ZThe interplay between Ras, Autophagy and cancer2667-394010.1016/j.adcanc.2021.100014https://doaj.org/article/246a4353ec46418e85dae627819ff69e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667394021000149https://doaj.org/toc/2667-3940Autophagy is an evolutionary conserved process of self-degradation and turnover of cellular components. The role of autophagy in human diseases is complexed as it can promote or inhibit disease progression. In cancer, autophagy can be detrimental or protective, depending on cellular contexts. Ras, a small GTPase, regulates various cell-signaling pathways, most of which are related to cell growth, survival and proliferation. Importantly, mutations in Ras appear in more than 30% of human cancers. In the current review, we will discuss the connection between Ras, autophagy and cancer development. It seems that Ras can promote or suppress autophagy by affecting numerous signaling pathways. In turn, depending on the cellular system, autophagy can affect the tumorigenicity driven by Ras. Also, Ras inhibitors can induce tumor-protective autophagy, while other anti-Ras agents which induce autophagy can promote anti-cancer effect of the treatment. Additionally, the effect of Ras inhibitors on autophagy with and without co-treatment with other agents will be discussed.Eran SchmuklerRonit Pinkas-KramarskiElsevierarticleRasAutophagyCell signalingNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENAdvances in Cancer Biology - Metastasis, Vol 3, Iss , Pp 100014- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ras Autophagy Cell signaling Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Ras Autophagy Cell signaling Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Eran Schmukler Ronit Pinkas-Kramarski The interplay between Ras, Autophagy and cancer
description	Autophagy is an evolutionary conserved process of self-degradation and turnover of cellular components. The role of autophagy in human diseases is complexed as it can promote or inhibit disease progression. In cancer, autophagy can be detrimental or protective, depending on cellular contexts. Ras, a small GTPase, regulates various cell-signaling pathways, most of which are related to cell growth, survival and proliferation. Importantly, mutations in Ras appear in more than 30% of human cancers. In the current review, we will discuss the connection between Ras, autophagy and cancer development. It seems that Ras can promote or suppress autophagy by affecting numerous signaling pathways. In turn, depending on the cellular system, autophagy can affect the tumorigenicity driven by Ras. Also, Ras inhibitors can induce tumor-protective autophagy, while other anti-Ras agents which induce autophagy can promote anti-cancer effect of the treatment. Additionally, the effect of Ras inhibitors on autophagy with and without co-treatment with other agents will be discussed.
format	article
author	Eran Schmukler Ronit Pinkas-Kramarski
author_facet	Eran Schmukler Ronit Pinkas-Kramarski
author_sort	Eran Schmukler
title	The interplay between Ras, Autophagy and cancer
title_short	The interplay between Ras, Autophagy and cancer
title_full	The interplay between Ras, Autophagy and cancer
title_fullStr	The interplay between Ras, Autophagy and cancer
title_full_unstemmed	The interplay between Ras, Autophagy and cancer
title_sort	interplay between ras, autophagy and cancer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/246a4353ec46418e85dae627819ff69e
work_keys_str_mv	AT eranschmukler theinterplaybetweenrasautophagyandcancer AT ronitpinkaskramarski theinterplaybetweenrasautophagyandcancer AT eranschmukler interplaybetweenrasautophagyandcancer AT ronitpinkaskramarski interplaybetweenrasautophagyandcancer
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The interplay between Ras, Autophagy and cancer

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