Proton beam therapy in non-small cell lung cancer: state of the art

Hideyuki Harada, Shigeyuki Murayama Radiation and Proton Therapy Center, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan Abstract: This review summarizes the past and present status of proton beam therapy (PBT) for lung cancer. PBT has a unique characteristic called the Bragg pe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Harada H, Murayama S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	3DCRT IMRT Proton beam Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/246ef29c3cc74509847e764e9e6a74fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:246ef29c3cc74509847e764e9e6a74fe
record_format	dspace
spelling	oai:doaj.org-article:246ef29c3cc74509847e764e9e6a74fe2021-12-02T02:17:38ZProton beam therapy in non-small cell lung cancer: state of the art1179-2728https://doaj.org/article/246ef29c3cc74509847e764e9e6a74fe2017-08-01T00:00:00Zhttps://www.dovepress.com/proton-beam-therapy-in-non-small-cell-lung-cancer-state-of-the-art-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Hideyuki Harada, Shigeyuki Murayama Radiation and Proton Therapy Center, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan Abstract: This review summarizes the past and present status of proton beam therapy (PBT) for lung cancer. PBT has a unique characteristic called the Bragg peak that enables a reduction in the dose of normal tissue around the tumor, but is sensitive to the uncertainties of density changes. The heterogeneity in electron density for thoracic lesions, such as those in the lung and mediastinum, and tumor movement according to respiration necessitates respiratory management for PBT to be applied in lung cancer patients. There are two types of PBT – a passively scattered approach and a scanning approach. Typically, a passively scattered approach is more robust for respiratory movement and a scanning approach could result in a more conformal dose distribution even when the tumor shape is complex. Large tumors of centrally located lung cancer may be more suitably irradiated than with intensity-modulated radiotherapy (IMRT) or stereotactic body radiotherapy (SBRT). For a locally advanced lung cancer, PBT can spare the lung and heart more than photon IMRT. However, no randomized controlled trial has reported differences between PBT and IMRT or SBRT for early-stage and locally advanced lung cancers. Therefore, a well-designed controlled trial is warranted. Keywords: proton beam therapy, non-small cell lung cancer, survival, SBRT, IMRTHarada HMurayama SDove Medical Pressarticle3DCRTIMRTProton beamNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol Volume 8, Pp 141-145 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	3DCRT IMRT Proton beam Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	3DCRT IMRT Proton beam Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Harada H Murayama S Proton beam therapy in non-small cell lung cancer: state of the art
description	Hideyuki Harada, Shigeyuki Murayama Radiation and Proton Therapy Center, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan Abstract: This review summarizes the past and present status of proton beam therapy (PBT) for lung cancer. PBT has a unique characteristic called the Bragg peak that enables a reduction in the dose of normal tissue around the tumor, but is sensitive to the uncertainties of density changes. The heterogeneity in electron density for thoracic lesions, such as those in the lung and mediastinum, and tumor movement according to respiration necessitates respiratory management for PBT to be applied in lung cancer patients. There are two types of PBT – a passively scattered approach and a scanning approach. Typically, a passively scattered approach is more robust for respiratory movement and a scanning approach could result in a more conformal dose distribution even when the tumor shape is complex. Large tumors of centrally located lung cancer may be more suitably irradiated than with intensity-modulated radiotherapy (IMRT) or stereotactic body radiotherapy (SBRT). For a locally advanced lung cancer, PBT can spare the lung and heart more than photon IMRT. However, no randomized controlled trial has reported differences between PBT and IMRT or SBRT for early-stage and locally advanced lung cancers. Therefore, a well-designed controlled trial is warranted. Keywords: proton beam therapy, non-small cell lung cancer, survival, SBRT, IMRT
format	article
author	Harada H Murayama S
author_facet	Harada H Murayama S
author_sort	Harada H
title	Proton beam therapy in non-small cell lung cancer: state of the art
title_short	Proton beam therapy in non-small cell lung cancer: state of the art
title_full	Proton beam therapy in non-small cell lung cancer: state of the art
title_fullStr	Proton beam therapy in non-small cell lung cancer: state of the art
title_full_unstemmed	Proton beam therapy in non-small cell lung cancer: state of the art
title_sort	proton beam therapy in non-small cell lung cancer: state of the art
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/246ef29c3cc74509847e764e9e6a74fe
work_keys_str_mv	AT haradah protonbeamtherapyinnonsmallcelllungcancerstateoftheart AT murayamas protonbeamtherapyinnonsmallcelllungcancerstateoftheart
_version_	1718402580122435584

Proton beam therapy in non-small cell lung cancer: state of the art

Ejemplares similares