Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in <named-content content-type="genus-species">Klebsiella pneumoniae</named-content>

Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in <named-content content-type="genus-species">Klebsiella pneumoniae</named-content>

ABSTRACT In Gram-negative bacteria, the permeability of the outer membrane governs rates of antibiotic uptake and thus the efficacy of antimicrobial treatment. Hydrophilic drugs like β-lactam antibiotics depend on diffusion through pore-forming outer membrane proteins to reach their intracellular ta...

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Detalles Bibliográficos
Autores principales: Andrea Rocker, Jake A. Lacey, Matthew J. Belousoff, Jonathan J. Wilksch, Richard A. Strugnell, Mark R. Davies, Trevor Lithgow
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
antimicrobial resistance
porin
OmpK37
beta-barrel
carbapenem
carbapenems
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/247288d710f642659e2235f566ef4e3c
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