Cardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction

Abstract Clinical trials with autologous adipose‐derived stem cell (AdSC) therapy for ischemic heart diseases (IHDs) are ongoing. However, little is known about combinational therapeutic effect of AdSCs and statin poly(lactic‐co‐glycolic) acid (PLGA) nanoparticles on the ischemic myocardium. We inve...

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Autores principales:	Ryo Yokoyama, Masaaki Ii, Yasuhiko Tabata, Masaaki Hoshiga, Nobukazu Ishizaka, Michio Asahi
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2019
Materias:	Adipose stem cells Cardiac Stem cell transplantation Tissue regeneration Medicine (General) R5-920 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/24738930a07e4479a6e612a7706ea7c7
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spelling	oai:doaj.org-article:24738930a07e4479a6e612a7706ea7c72021-11-30T19:15:37ZCardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction2157-65802157-656410.1002/sctm.18-0244https://doaj.org/article/24738930a07e4479a6e612a7706ea7c72019-10-01T00:00:00Zhttps://doi.org/10.1002/sctm.18-0244https://doaj.org/toc/2157-6564https://doaj.org/toc/2157-6580Abstract Clinical trials with autologous adipose‐derived stem cell (AdSC) therapy for ischemic heart diseases (IHDs) are ongoing. However, little is known about combinational therapeutic effect of AdSCs and statin poly(lactic‐co‐glycolic) acid (PLGA) nanoparticles on the ischemic myocardium. We investigated the hypothesis that statins, which have pleiotropic effects, augment the therapeutic potential of AdSCs and that AdSCs also act as drug delivery tools. Simvastatin‐conjugated nanoparticles (SimNPs) significantly promoted migration activity without changing proliferation activity and upregulated growth factor gene expression in vitro. A small number of intravenously administered SimNP‐loaded AdSCs (10,000 cells per mouse) improved cardiac function following myocardial infarction, inducing endogenous cardiac regeneration in the infarcted myocardium. The de novo regenerated myocardium was thought to be derived from epicardial cells, which were positive for Wilms' tumor protein 1 expression. These findings were attributed to the sustained, local simvastatin release from the recruited SimNP‐loaded AdSCs in the infarcted myocardium rather than to the direct contribution of recruited AdSCs to tissue regeneration. SimNP‐loaded AdSCs may lead to a novel somatic stem cell therapy for IHDs. Stem Cells Translational Medicine 2019;8:1055–1067Ryo YokoyamaMasaaki IiYasuhiko TabataMasaaki HoshigaNobukazu IshizakaMichio AsahiWileyarticleAdipose stem cellsCardiacStem cell transplantationTissue regenerationMedicine (General)R5-920CytologyQH573-671ENStem Cells Translational Medicine, Vol 8, Iss 10, Pp 1055-1067 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adipose stem cells Cardiac Stem cell transplantation Tissue regeneration Medicine (General) R5-920 Cytology QH573-671
spellingShingle	Adipose stem cells Cardiac Stem cell transplantation Tissue regeneration Medicine (General) R5-920 Cytology QH573-671 Ryo Yokoyama Masaaki Ii Yasuhiko Tabata Masaaki Hoshiga Nobukazu Ishizaka Michio Asahi Cardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction
description	Abstract Clinical trials with autologous adipose‐derived stem cell (AdSC) therapy for ischemic heart diseases (IHDs) are ongoing. However, little is known about combinational therapeutic effect of AdSCs and statin poly(lactic‐co‐glycolic) acid (PLGA) nanoparticles on the ischemic myocardium. We investigated the hypothesis that statins, which have pleiotropic effects, augment the therapeutic potential of AdSCs and that AdSCs also act as drug delivery tools. Simvastatin‐conjugated nanoparticles (SimNPs) significantly promoted migration activity without changing proliferation activity and upregulated growth factor gene expression in vitro. A small number of intravenously administered SimNP‐loaded AdSCs (10,000 cells per mouse) improved cardiac function following myocardial infarction, inducing endogenous cardiac regeneration in the infarcted myocardium. The de novo regenerated myocardium was thought to be derived from epicardial cells, which were positive for Wilms' tumor protein 1 expression. These findings were attributed to the sustained, local simvastatin release from the recruited SimNP‐loaded AdSCs in the infarcted myocardium rather than to the direct contribution of recruited AdSCs to tissue regeneration. SimNP‐loaded AdSCs may lead to a novel somatic stem cell therapy for IHDs. Stem Cells Translational Medicine 2019;8:1055–1067
format	article
author	Ryo Yokoyama Masaaki Ii Yasuhiko Tabata Masaaki Hoshiga Nobukazu Ishizaka Michio Asahi
author_facet	Ryo Yokoyama Masaaki Ii Yasuhiko Tabata Masaaki Hoshiga Nobukazu Ishizaka Michio Asahi
author_sort	Ryo Yokoyama
title	Cardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction
title_short	Cardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction
title_full	Cardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction
title_fullStr	Cardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction
title_full_unstemmed	Cardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction
title_sort	cardiac regeneration by statin‐polymer nanoparticle‐loaded adipose‐derived stem cell therapy in myocardial infarction
publisher	Wiley
publishDate	2019
url	https://doaj.org/article/24738930a07e4479a6e612a7706ea7c7
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Cardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction

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