New optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements

Inbar Yariv,1 Menashe Haddad,2,3 Hamootal Duadi,1 Menachem Motiei,1 Dror Fixler1 1Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 3Mayanei Hayeshua Medical...

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Autores principales:	Yariv I, Haddad M, Duadi H, Motiei M, Fixler D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Gerchberg-Saxton optical properties gold nanorods blood vessel tissue viability reflectance scattering. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2478cd9e2d1d470a87cfaa4381faea97
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spelling	oai:doaj.org-article:2478cd9e2d1d470a87cfaa4381faea972021-12-02T04:28:18ZNew optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements1178-2013https://doaj.org/article/2478cd9e2d1d470a87cfaa4381faea972016-10-01T00:00:00Zhttps://www.dovepress.com/new-optical-sensing-technique-of-tissue-viability-and-blood-flow-based-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Inbar Yariv,1 Menashe Haddad,2,3 Hamootal Duadi,1 Menachem Motiei,1 Dror Fixler1 1Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 3Mayanei Hayeshua Medical Center, Benei Brak, Israel Abstract: Physiological substances pose a challenge for researchers since their optical properties change constantly according to their physiological state. Examination of those substances noninvasively can be achieved by different optical methods with high sensitivity. Our research suggests the application of a novel noninvasive nanophotonics technique, ie, iterative multi-plane optical property extraction (IMOPE) based on reflectance measurements, for tissue viability examination and gold nanorods (GNRs) and blood flow detection. The IMOPE model combines an experimental setup designed for recording light intensity images with the multi-plane iterative Gerchberg-Saxton algorithm for reconstructing the reemitted light phase and calculating its standard deviation (STD). Changes in tissue composition affect its optical properties which results in changes in the light phase that can be measured by its STD. We have demonstrated this new concept of correlating the light phase STD and the optical properties of a substance, using transmission measurements only. This paper presents, for the first time, reflectance based IMOPE tissue viability examination, producing a decrease in the computed STD for older tissues, as well as investigating their organic material absorption capability. Finally, differentiation of the femoral vein from adjacent tissues using GNRs and the detection of their presence within blood circulation and tissues are also presented with high sensitivity (better than computed tomography) to low quantities of GNRs (<3 mg). Keywords: Gerchberg-Saxton, optical properties, gold nanorods, blood vessel, tissue viability, reflectance, scatteringYariv IHaddad MDuadi HMotiei MFixler DDove Medical PressarticleGerchberg-Saxtonoptical propertiesgold nanorodsblood vesseltissue viabilityreflectancescattering.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 5237-5244 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gerchberg-Saxton optical properties gold nanorods blood vessel tissue viability reflectance scattering. Medicine (General) R5-920
spellingShingle	Gerchberg-Saxton optical properties gold nanorods blood vessel tissue viability reflectance scattering. Medicine (General) R5-920 Yariv I Haddad M Duadi H Motiei M Fixler D New optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements
description	Inbar Yariv,1 Menashe Haddad,2,3 Hamootal Duadi,1 Menachem Motiei,1 Dror Fixler1 1Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 3Mayanei Hayeshua Medical Center, Benei Brak, Israel Abstract: Physiological substances pose a challenge for researchers since their optical properties change constantly according to their physiological state. Examination of those substances noninvasively can be achieved by different optical methods with high sensitivity. Our research suggests the application of a novel noninvasive nanophotonics technique, ie, iterative multi-plane optical property extraction (IMOPE) based on reflectance measurements, for tissue viability examination and gold nanorods (GNRs) and blood flow detection. The IMOPE model combines an experimental setup designed for recording light intensity images with the multi-plane iterative Gerchberg-Saxton algorithm for reconstructing the reemitted light phase and calculating its standard deviation (STD). Changes in tissue composition affect its optical properties which results in changes in the light phase that can be measured by its STD. We have demonstrated this new concept of correlating the light phase STD and the optical properties of a substance, using transmission measurements only. This paper presents, for the first time, reflectance based IMOPE tissue viability examination, producing a decrease in the computed STD for older tissues, as well as investigating their organic material absorption capability. Finally, differentiation of the femoral vein from adjacent tissues using GNRs and the detection of their presence within blood circulation and tissues are also presented with high sensitivity (better than computed tomography) to low quantities of GNRs (<3 mg). Keywords: Gerchberg-Saxton, optical properties, gold nanorods, blood vessel, tissue viability, reflectance, scattering
format	article
author	Yariv I Haddad M Duadi H Motiei M Fixler D
author_facet	Yariv I Haddad M Duadi H Motiei M Fixler D
author_sort	Yariv I
title	New optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements
title_short	New optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements
title_full	New optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements
title_fullStr	New optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements
title_full_unstemmed	New optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements
title_sort	new optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/2478cd9e2d1d470a87cfaa4381faea97
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New optical sensing technique of tissue viability and blood flow based on nanophotonic iterative multi-plane reflectance measurements

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