Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA

The spliceosome removes introns from precursor messenger RNAs to produce mature mRNAs. Here the authors report a U6 snRNP crystal structure that provides insight on how the 3′ phosphate of U6 snRNA is recognized by the Lsm2–8 complex and how the U6 snRNP proteins sequester and protect the active sit...

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Autores principales:	Eric J. Montemayor, Allison L. Didychuk, Allyson D. Yake, Gurnimrat K. Sidhu, David A. Brow, Samuel E. Butcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/247c7acfc7f34bfb91ac25bc3292cfd3
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spelling	oai:doaj.org-article:247c7acfc7f34bfb91ac25bc3292cfd32021-12-02T17:33:18ZArchitecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA10.1038/s41467-018-04145-42041-1723https://doaj.org/article/247c7acfc7f34bfb91ac25bc3292cfd32018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04145-4https://doaj.org/toc/2041-1723The spliceosome removes introns from precursor messenger RNAs to produce mature mRNAs. Here the authors report a U6 snRNP crystal structure that provides insight on how the 3′ phosphate of U6 snRNA is recognized by the Lsm2–8 complex and how the U6 snRNP proteins sequester and protect the active site RNA until it is assembled into the spliceosome.Eric J. MontemayorAllison L. DidychukAllyson D. YakeGurnimrat K. SidhuDavid A. BrowSamuel E. ButcherNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eric J. Montemayor Allison L. Didychuk Allyson D. Yake Gurnimrat K. Sidhu David A. Brow Samuel E. Butcher Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA
description	The spliceosome removes introns from precursor messenger RNAs to produce mature mRNAs. Here the authors report a U6 snRNP crystal structure that provides insight on how the 3′ phosphate of U6 snRNA is recognized by the Lsm2–8 complex and how the U6 snRNP proteins sequester and protect the active site RNA until it is assembled into the spliceosome.
format	article
author	Eric J. Montemayor Allison L. Didychuk Allyson D. Yake Gurnimrat K. Sidhu David A. Brow Samuel E. Butcher
author_facet	Eric J. Montemayor Allison L. Didychuk Allyson D. Yake Gurnimrat K. Sidhu David A. Brow Samuel E. Butcher
author_sort	Eric J. Montemayor
title	Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA
title_short	Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA
title_full	Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA
title_fullStr	Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA
title_full_unstemmed	Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA
title_sort	architecture of the u6 snrnp reveals specific recognition of 3′-end processed u6 snrna
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/247c7acfc7f34bfb91ac25bc3292cfd3
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Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA

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