Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.

<h4>Purpose</h4>To investigate the relationship between disruption in different photoreceptor layers and deep capillary plexus (DCP) telangiectasias in eyes with macular telangiectasia type 2 (MacTel).<h4>Methods</h4>35 eyes (21 patients) with MacTel imaged with optical coher...

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Autores principales:	Janice X Ong, Roya Zandi, Amani A Fawzi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/247f7a0b05c240a0a502819c25f51127
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spelling	oai:doaj.org-article:247f7a0b05c240a0a502819c25f511272021-12-02T20:13:14ZEarly-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.1932-620310.1371/journal.pone.0259811https://doaj.org/article/247f7a0b05c240a0a502819c25f511272021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259811https://doaj.org/toc/1932-6203<h4>Purpose</h4>To investigate the relationship between disruption in different photoreceptor layers and deep capillary plexus (DCP) telangiectasias in eyes with macular telangiectasia type 2 (MacTel).<h4>Methods</h4>35 eyes (21 patients) with MacTel imaged with optical coherence tomography angiography (OCTA) were included. Circumscribed areas of DCP telangiectasia were traced from OCTA slabs and the corresponding spectral-domain OCT (SD-OCT) slabs were used to visualize the photoreceptor layer interdigitation zone (IZ) and ellipsoid zone (EZ). IZ attenuation, IZ loss, and EZ loss were graded by reviewing en face SD-OCT slabs for hypo-reflective areas and confirming their status on cross-sectional views. Total area of photoreceptor disruption and overlap with DCP telangiectasia were evaluated with respect to OCT-based MacTel stage. Longitudinal changes were evaluated in a subset of patients with follow-up imaging.<h4>Results</h4>Overlap of DCP telangiectasia with IZ attenuation significantly decreased with MacTel severity, while overlap with IZ and EZ loss significantly increased. Overlap with IZ loss peaked in moderate MacTel (Stages 3-5). Longitudinal imaging showed that new EZ loss at 6 months was largely predicted by baseline IZ loss.<h4>Conclusions</h4>Worsening MacTel severity is characterized by greater overlap between DCP telangiectasia and zones of increasing severity of photoreceptor disruption, with EZ loss enlarging over time within areas of preexisting IZ disruption. We suggest that IZ disruption may indicate early photoreceptor dysfunction that eventually progresses to EZ loss, with IZ loss being a more reliable metric than IZ attenuation. Additional studies will be necessary to further explore long-term photoreceptor changes and evaluate their relationship with visual function in MacTel.Janice X OngRoya ZandiAmani A FawziPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259811 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Janice X Ong Roya Zandi Amani A Fawzi Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.
description	<h4>Purpose</h4>To investigate the relationship between disruption in different photoreceptor layers and deep capillary plexus (DCP) telangiectasias in eyes with macular telangiectasia type 2 (MacTel).<h4>Methods</h4>35 eyes (21 patients) with MacTel imaged with optical coherence tomography angiography (OCTA) were included. Circumscribed areas of DCP telangiectasia were traced from OCTA slabs and the corresponding spectral-domain OCT (SD-OCT) slabs were used to visualize the photoreceptor layer interdigitation zone (IZ) and ellipsoid zone (EZ). IZ attenuation, IZ loss, and EZ loss were graded by reviewing en face SD-OCT slabs for hypo-reflective areas and confirming their status on cross-sectional views. Total area of photoreceptor disruption and overlap with DCP telangiectasia were evaluated with respect to OCT-based MacTel stage. Longitudinal changes were evaluated in a subset of patients with follow-up imaging.<h4>Results</h4>Overlap of DCP telangiectasia with IZ attenuation significantly decreased with MacTel severity, while overlap with IZ and EZ loss significantly increased. Overlap with IZ loss peaked in moderate MacTel (Stages 3-5). Longitudinal imaging showed that new EZ loss at 6 months was largely predicted by baseline IZ loss.<h4>Conclusions</h4>Worsening MacTel severity is characterized by greater overlap between DCP telangiectasia and zones of increasing severity of photoreceptor disruption, with EZ loss enlarging over time within areas of preexisting IZ disruption. We suggest that IZ disruption may indicate early photoreceptor dysfunction that eventually progresses to EZ loss, with IZ loss being a more reliable metric than IZ attenuation. Additional studies will be necessary to further explore long-term photoreceptor changes and evaluate their relationship with visual function in MacTel.
format	article
author	Janice X Ong Roya Zandi Amani A Fawzi
author_facet	Janice X Ong Roya Zandi Amani A Fawzi
author_sort	Janice X Ong
title	Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.
title_short	Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.
title_full	Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.
title_fullStr	Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.
title_full_unstemmed	Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.
title_sort	early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/247f7a0b05c240a0a502819c25f51127
work_keys_str_mv	AT janicexong earlystagemaculartelangiectasiatype2vascularabnormalitiesareassociatedwithinterdigitationzonedisruption AT royazandi earlystagemaculartelangiectasiatype2vascularabnormalitiesareassociatedwithinterdigitationzonedisruption AT amaniafawzi earlystagemaculartelangiectasiatype2vascularabnormalitiesareassociatedwithinterdigitationzonedisruption
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Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.

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