Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.

<h4>Purpose</h4>To compare adiponectin (APN) levels in the serum and aqueous humor (AH) and evaluate their association with the development/progression of diabetic retinopathy (DR).<h4>Methods</h4>Diabetic patients with (group 3; n = 59) and without (group 2; n = 39) DR and a...

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Autores principales:	Hyun Seung Yang, Young Je Choi, Hee Yong Han, Hak Su Kim, So Hyun Park, Kyung Sub Lee, Sang Hwa Lim, Doo Jin Heo, Sangkyung Choi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24816d430e65411d9a1ce8de7c786800
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spelling	oai:doaj.org-article:24816d430e65411d9a1ce8de7c7868002021-12-02T20:13:07ZSerum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.1932-620310.1371/journal.pone.0259683https://doaj.org/article/24816d430e65411d9a1ce8de7c7868002021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259683https://doaj.org/toc/1932-6203<h4>Purpose</h4>To compare adiponectin (APN) levels in the serum and aqueous humor (AH) and evaluate their association with the development/progression of diabetic retinopathy (DR).<h4>Methods</h4>Diabetic patients with (group 3; n = 59) and without (group 2; n = 39) DR and age- and sex-matched normal subjects (group 1; n = 35) were compared. Duration of diabetes, body mass index, serum HbA1c, vascular endothelial growth factor (VEGF), APN, pentraxin 3 (PTX3), platelet derived growth factor (PDGF), intercellular adhesion molecule-1 (ICAM-1), and APN were measured and analyzed.<h4>Results</h4>One hundred and thirty-three participants were included. Compared to patients without diabetes, diabetic patients with DR had significantly elevated average serum APN levels (5.99±3.89 μg/ml versus 3.51±1.44 μg/ml, P = 0.002) and average AH APN levels (10.94±11.74 ng/ml versus 3.65±3.33 ng/ml, P<0.001). Serum APN was significantly correlated with AH APN (R = 0.512, P<0.001) and AH VEGF (R = 0.202, P = 0.020). The log serum APN was significantly correlated with intraocular cytokines, including log APN, log VEGF, log ICAM, log leptin, log PTX3, log PDGF, angiopoietin, C-reactive protein, and interleukins (IL)-5 and IL-10 (P<0.001, P = 0.020, P<0.001, P<0.001, P = 0.001, P<0.001, P = 0.008, P = 0.009, P<0.001, and P = 0.046, respectively). Log serum VEGF showed a significant correlation only with log AH VEGF (P = 0.001). Multivariate logistic analysis was performed to evaluate the association of DR progression and cytokine concentrations; log Serum APN and log AH APN showed good correlation with the DR progression in each model.<h4>Conclusions</h4>AH APN levels correlated well with DR development and progression. Serum APN could be a better marker for estimating intraocular cytokines, including both intraocular APN and VEGF concentrations in clinical field, than serum VEGF in DR patients.Hyun Seung YangYoung Je ChoiHee Yong HanHak Su KimSo Hyun ParkKyung Sub LeeSang Hwa LimDoo Jin HeoSangkyung ChoiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259683 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyun Seung Yang Young Je Choi Hee Yong Han Hak Su Kim So Hyun Park Kyung Sub Lee Sang Hwa Lim Doo Jin Heo Sangkyung Choi Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.
description	<h4>Purpose</h4>To compare adiponectin (APN) levels in the serum and aqueous humor (AH) and evaluate their association with the development/progression of diabetic retinopathy (DR).<h4>Methods</h4>Diabetic patients with (group 3; n = 59) and without (group 2; n = 39) DR and age- and sex-matched normal subjects (group 1; n = 35) were compared. Duration of diabetes, body mass index, serum HbA1c, vascular endothelial growth factor (VEGF), APN, pentraxin 3 (PTX3), platelet derived growth factor (PDGF), intercellular adhesion molecule-1 (ICAM-1), and APN were measured and analyzed.<h4>Results</h4>One hundred and thirty-three participants were included. Compared to patients without diabetes, diabetic patients with DR had significantly elevated average serum APN levels (5.99±3.89 μg/ml versus 3.51±1.44 μg/ml, P = 0.002) and average AH APN levels (10.94±11.74 ng/ml versus 3.65±3.33 ng/ml, P<0.001). Serum APN was significantly correlated with AH APN (R = 0.512, P<0.001) and AH VEGF (R = 0.202, P = 0.020). The log serum APN was significantly correlated with intraocular cytokines, including log APN, log VEGF, log ICAM, log leptin, log PTX3, log PDGF, angiopoietin, C-reactive protein, and interleukins (IL)-5 and IL-10 (P<0.001, P = 0.020, P<0.001, P<0.001, P = 0.001, P<0.001, P = 0.008, P = 0.009, P<0.001, and P = 0.046, respectively). Log serum VEGF showed a significant correlation only with log AH VEGF (P = 0.001). Multivariate logistic analysis was performed to evaluate the association of DR progression and cytokine concentrations; log Serum APN and log AH APN showed good correlation with the DR progression in each model.<h4>Conclusions</h4>AH APN levels correlated well with DR development and progression. Serum APN could be a better marker for estimating intraocular cytokines, including both intraocular APN and VEGF concentrations in clinical field, than serum VEGF in DR patients.
format	article
author	Hyun Seung Yang Young Je Choi Hee Yong Han Hak Su Kim So Hyun Park Kyung Sub Lee Sang Hwa Lim Doo Jin Heo Sangkyung Choi
author_facet	Hyun Seung Yang Young Je Choi Hee Yong Han Hak Su Kim So Hyun Park Kyung Sub Lee Sang Hwa Lim Doo Jin Heo Sangkyung Choi
author_sort	Hyun Seung Yang
title	Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.
title_short	Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.
title_full	Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.
title_fullStr	Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.
title_full_unstemmed	Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.
title_sort	serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/24816d430e65411d9a1ce8de7c786800
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Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.

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