ACCURACY OF CA-125 CONCENTRATION AS PREDICTOR OF PERITONEAL DISSEMINATION OF COLO-RECTAL CARCINOMA

Objective: To determine the association of CA-125 levels with the peritoneal dissemination among the patients of colo-rectal carcinoma at a tertiary care surgical oncology unit of Pakistan Study Design: Observational study. Place and Duration of Study: Department of Surgical Oncology, Combi...

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Autores principales:	Rasikh Maqsood, Tanveer Abbas, Muhammad Talha Akhtar, Muhammad Usama Akhtar, Muhammad Ayub Ashraf Mallhi, Mubashar Ahmad Bajwa
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	peritoneal dissemination colo-rectal cancer Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2482c1f7cde54818ad14509bb29fc974
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spelling	oai:doaj.org-article:2482c1f7cde54818ad14509bb29fc9742021-11-30T03:07:56ZACCURACY OF CA-125 CONCENTRATION AS PREDICTOR OF PERITONEAL DISSEMINATION OF COLO-RECTAL CARCINOMA0030-96482411-8842https://doaj.org/article/2482c1f7cde54818ad14509bb29fc9742018-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2609/2124https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the association of CA-125 levels with the peritoneal dissemination among the patients of colo-rectal carcinoma at a tertiary care surgical oncology unit of Pakistan Study Design: Observational study. Place and Duration of Study: Department of Surgical Oncology, Combined Military Hospital Rawalpindi. Duration of ten months, from Jan 2018 to Oct 2018. Patients and Methods: A total of 83 cases of colorectal carcinoma were included in the study, which were diagnosed by consultant oncologist after relevant histological and radiological investigations. Peritoneal dissemination was confirmed during the surgery. CA-125 levels were assessed before the surgery and cut off of 35U/mL was used. Relationship of age, gender, raised CA-125, tumor metastasis and tumor differentiation was assessed with the presence of peritoneal dissemination among the patients suffering from colo-rectal cancer. Results: Fifty nine patients were males and 24 were females. Mean age of the patients was 51.17 (±3.395). Out of 83 patients of colo-rectal cancer, 37.3% showed the presence of peritoneal dissemination while 62.7% had no peritoneal dissemination at the time of surgery. Forty one patients had raised levels of CA-125 while 42 had levels within the normal range. After applying the logistic regression we found that raised levels of CA-125 and metastatic illness had significant association with the presence of peritoneal dissemination among the patients of colo-rectal cancer. Conclusion: CA-125 concentration emerged as a strong predictor of peritoneal dissemination of colo-rectal cancer in our study analysis. Routine checking of levels of this marker among the patients of Colon cancer may help in early recognition of the advancement of disease and help the surgical oncologists to manage it in a more effective way.Rasikh MaqsoodTanveer AbbasMuhammad Talha AkhtarMuhammad Usama AkhtarMuhammad Ayub Ashraf MallhiMubashar Ahmad BajwaArmy Medical College Rawalpindiarticleperitoneal disseminationcolo-rectalcancerMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 6, Pp 1761-1764 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	peritoneal dissemination colo-rectal cancer Medicine R Medicine (General) R5-920
spellingShingle	peritoneal dissemination colo-rectal cancer Medicine R Medicine (General) R5-920 Rasikh Maqsood Tanveer Abbas Muhammad Talha Akhtar Muhammad Usama Akhtar Muhammad Ayub Ashraf Mallhi Mubashar Ahmad Bajwa ACCURACY OF CA-125 CONCENTRATION AS PREDICTOR OF PERITONEAL DISSEMINATION OF COLO-RECTAL CARCINOMA
description	Objective: To determine the association of CA-125 levels with the peritoneal dissemination among the patients of colo-rectal carcinoma at a tertiary care surgical oncology unit of Pakistan Study Design: Observational study. Place and Duration of Study: Department of Surgical Oncology, Combined Military Hospital Rawalpindi. Duration of ten months, from Jan 2018 to Oct 2018. Patients and Methods: A total of 83 cases of colorectal carcinoma were included in the study, which were diagnosed by consultant oncologist after relevant histological and radiological investigations. Peritoneal dissemination was confirmed during the surgery. CA-125 levels were assessed before the surgery and cut off of 35U/mL was used. Relationship of age, gender, raised CA-125, tumor metastasis and tumor differentiation was assessed with the presence of peritoneal dissemination among the patients suffering from colo-rectal cancer. Results: Fifty nine patients were males and 24 were females. Mean age of the patients was 51.17 (±3.395). Out of 83 patients of colo-rectal cancer, 37.3% showed the presence of peritoneal dissemination while 62.7% had no peritoneal dissemination at the time of surgery. Forty one patients had raised levels of CA-125 while 42 had levels within the normal range. After applying the logistic regression we found that raised levels of CA-125 and metastatic illness had significant association with the presence of peritoneal dissemination among the patients of colo-rectal cancer. Conclusion: CA-125 concentration emerged as a strong predictor of peritoneal dissemination of colo-rectal cancer in our study analysis. Routine checking of levels of this marker among the patients of Colon cancer may help in early recognition of the advancement of disease and help the surgical oncologists to manage it in a more effective way.
format	article
author	Rasikh Maqsood Tanveer Abbas Muhammad Talha Akhtar Muhammad Usama Akhtar Muhammad Ayub Ashraf Mallhi Mubashar Ahmad Bajwa
author_facet	Rasikh Maqsood Tanveer Abbas Muhammad Talha Akhtar Muhammad Usama Akhtar Muhammad Ayub Ashraf Mallhi Mubashar Ahmad Bajwa
author_sort	Rasikh Maqsood
title	ACCURACY OF CA-125 CONCENTRATION AS PREDICTOR OF PERITONEAL DISSEMINATION OF COLO-RECTAL CARCINOMA
title_short	ACCURACY OF CA-125 CONCENTRATION AS PREDICTOR OF PERITONEAL DISSEMINATION OF COLO-RECTAL CARCINOMA
title_full	ACCURACY OF CA-125 CONCENTRATION AS PREDICTOR OF PERITONEAL DISSEMINATION OF COLO-RECTAL CARCINOMA
title_fullStr	ACCURACY OF CA-125 CONCENTRATION AS PREDICTOR OF PERITONEAL DISSEMINATION OF COLO-RECTAL CARCINOMA
title_full_unstemmed	ACCURACY OF CA-125 CONCENTRATION AS PREDICTOR OF PERITONEAL DISSEMINATION OF COLO-RECTAL CARCINOMA
title_sort	accuracy of ca-125 concentration as predictor of peritoneal dissemination of colo-rectal carcinoma
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/2482c1f7cde54818ad14509bb29fc974
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ACCURACY OF CA-125 CONCENTRATION AS PREDICTOR OF PERITONEAL DISSEMINATION OF COLO-RECTAL CARCINOMA

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