Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation injury, implicating macrophage-derived WNT in intesti...

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Autores principales:	Subhrajit Saha, Evelyn Aranda, Yoku Hayakawa, Payel Bhanja, Safinur Atay, N Patrik Brodin, Jiufeng Li, Samuel Asfaha, Laibin Liu, Yagnesh Tailor, Jinghang Zhang, Andrew K. Godwin, Wolfgang A. Tome, Timothy C. Wang, Chandan Guha, Jeffrey W. Pollard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/248356ef46954e2da55e3e945b815504
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spelling	oai:doaj.org-article:248356ef46954e2da55e3e945b8155042021-12-02T14:40:16ZMacrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury10.1038/ncomms130962041-1723https://doaj.org/article/248356ef46954e2da55e3e945b8155042016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13096https://doaj.org/toc/2041-1723The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation injury, implicating macrophage-derived WNT in intestinal repair.Subhrajit SahaEvelyn ArandaYoku HayakawaPayel BhanjaSafinur AtayN Patrik BrodinJiufeng LiSamuel AsfahaLaibin LiuYagnesh TailorJinghang ZhangAndrew K. GodwinWolfgang A. TomeTimothy C. WangChandan GuhaJeffrey W. PollardNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Subhrajit Saha Evelyn Aranda Yoku Hayakawa Payel Bhanja Safinur Atay N Patrik Brodin Jiufeng Li Samuel Asfaha Laibin Liu Yagnesh Tailor Jinghang Zhang Andrew K. Godwin Wolfgang A. Tome Timothy C. Wang Chandan Guha Jeffrey W. Pollard Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
description	The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation injury, implicating macrophage-derived WNT in intestinal repair.
format	article
author	Subhrajit Saha Evelyn Aranda Yoku Hayakawa Payel Bhanja Safinur Atay N Patrik Brodin Jiufeng Li Samuel Asfaha Laibin Liu Yagnesh Tailor Jinghang Zhang Andrew K. Godwin Wolfgang A. Tome Timothy C. Wang Chandan Guha Jeffrey W. Pollard
author_facet	Subhrajit Saha Evelyn Aranda Yoku Hayakawa Payel Bhanja Safinur Atay N Patrik Brodin Jiufeng Li Samuel Asfaha Laibin Liu Yagnesh Tailor Jinghang Zhang Andrew K. Godwin Wolfgang A. Tome Timothy C. Wang Chandan Guha Jeffrey W. Pollard
author_sort	Subhrajit Saha
title	Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
title_short	Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
title_full	Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
title_fullStr	Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
title_full_unstemmed	Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
title_sort	macrophage-derived extracellular vesicle-packaged wnts rescue intestinal stem cells and enhance survival after radiation injury
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/248356ef46954e2da55e3e945b815504
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Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

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