Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study
AIM: To assess changed spontaneous brain activity in hyperthyroid exophthalmos (HE) patients by the amplitude of the low-frequency fluctuation (ALFF) method, and to analyze the correlation between brain activity and ALFF values in these patients. METHODS: Totally 18 HE and 18 hyperthyroid non-exopht...
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Press of International Journal of Ophthalmology (IJO PRESS)
2021
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oai:doaj.org-article:24838faa28294d55a73e67bc290791072021-11-26T04:02:12ZAltered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study2222-39592227-489810.18240/ijo.2021.12.22https://doaj.org/article/24838faa28294d55a73e67bc290791072021-12-01T00:00:00Zhttp://ies.ijo.cn/en_publish/2021/12/20211222.pdfhttps://doaj.org/toc/2222-3959https://doaj.org/toc/2227-4898AIM: To assess changed spontaneous brain activity in hyperthyroid exophthalmos (HE) patients by the amplitude of the low-frequency fluctuation (ALFF) method, and to analyze the correlation between brain activity and ALFF values in these patients. METHODS: Totally 18 HE and 18 hyperthyroid non-exophthalmos (HNE) patients were enrolled. The participants were tested by resting-state functional magnetic resonance imaging, and receiver operating characteristic (ROC) curves were generated to classify the ALFF values of the study population. Pearson's correlation analysis was utilized to evaluate the relationship between the ALFF values obtained from different brain areas and clinical manifestations. RESULTS: Contrary to HNE patients, we observed lower ALFF values in the left calcarine fissure and surrounding cortex (LCFSC) in HE patients. In the ROC curve analysis of the LCFSC, the area under the curve reflected a high degree of accuracy. In addition, there was positive correlation between mean ALFF values of the LCFSC and the best-corrected visual acuity of the affected eyes. CONCLUSION: The study displays abnormal brain activity in LCFSC in patients with HE, which might suggest pathological mechanism of visual impairment of HE patients.Ling LingWen-Feng LiuYu GuoRong-Bin LiangHui-Ye ShuLi-Juan ZhangQiu-Yu LiQian-Min GeYi-Cong PanYi ShaoPress of International Journal of Ophthalmology (IJO PRESS)articlehyperthyroid exophthalmosamplitude of low-frequency fluctuationfunctional magnetic resonance imagingspontaneous brain activityOphthalmologyRE1-994ENInternational Journal of Ophthalmology, Vol 14, Iss 12, Pp 1957-1962 (2021) |
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hyperthyroid exophthalmos amplitude of low-frequency fluctuation functional magnetic resonance imaging spontaneous brain activity Ophthalmology RE1-994 |
| spellingShingle |
hyperthyroid exophthalmos amplitude of low-frequency fluctuation functional magnetic resonance imaging spontaneous brain activity Ophthalmology RE1-994 Ling Ling Wen-Feng Liu Yu Guo Rong-Bin Liang Hui-Ye Shu Li-Juan Zhang Qiu-Yu Li Qian-Min Ge Yi-Cong Pan Yi Shao Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study |
| description |
AIM: To assess changed spontaneous brain activity in hyperthyroid exophthalmos (HE) patients by the amplitude of the low-frequency fluctuation (ALFF) method, and to analyze the correlation between brain activity and ALFF values in these patients. METHODS: Totally 18 HE and 18 hyperthyroid non-exophthalmos (HNE) patients were enrolled. The participants were tested by resting-state functional magnetic resonance imaging, and receiver operating characteristic (ROC) curves were generated to classify the ALFF values of the study population. Pearson's correlation analysis was utilized to evaluate the relationship between the ALFF values obtained from different brain areas and clinical manifestations. RESULTS: Contrary to HNE patients, we observed lower ALFF values in the left calcarine fissure and surrounding cortex (LCFSC) in HE patients. In the ROC curve analysis of the LCFSC, the area under the curve reflected a high degree of accuracy. In addition, there was positive correlation between mean ALFF values of the LCFSC and the best-corrected visual acuity of the affected eyes. CONCLUSION: The study displays abnormal brain activity in LCFSC in patients with HE, which might suggest pathological mechanism of visual impairment of HE patients. |
| format |
article |
| author |
Ling Ling Wen-Feng Liu Yu Guo Rong-Bin Liang Hui-Ye Shu Li-Juan Zhang Qiu-Yu Li Qian-Min Ge Yi-Cong Pan Yi Shao |
| author_facet |
Ling Ling Wen-Feng Liu Yu Guo Rong-Bin Liang Hui-Ye Shu Li-Juan Zhang Qiu-Yu Li Qian-Min Ge Yi-Cong Pan Yi Shao |
| author_sort |
Ling Ling |
| title |
Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study |
| title_short |
Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study |
| title_full |
Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study |
| title_fullStr |
Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study |
| title_full_unstemmed |
Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study |
| title_sort |
altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fmri study |
| publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/24838faa28294d55a73e67bc29079107 |
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