Salivary melatonin in oral squamous cell carcinoma patients

Abstract Melatonin’s role in circadian rhythm is well documented, as are its’ anti-oxidant, oncostatic and anti-inflammatory properties. Poor sleep quality has been associated as a potential risk factor for several malignancies, including head and neck cancers. The purpose of this study is to determ...

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Autores principales:	Ivan Salarić, Ivana Karmelić, Jasna Lovrić, Ksenija Baždarić, Marko Rožman, Igor Čvrljević, Ivan Zajc, Davor Brajdić, Darko Macan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/248617a206d640768138e1f2e54309d2
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spelling	oai:doaj.org-article:248617a206d640768138e1f2e54309d22021-12-02T17:12:21ZSalivary melatonin in oral squamous cell carcinoma patients10.1038/s41598-021-92649-32045-2322https://doaj.org/article/248617a206d640768138e1f2e54309d22021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92649-3https://doaj.org/toc/2045-2322Abstract Melatonin’s role in circadian rhythm is well documented, as are its’ anti-oxidant, oncostatic and anti-inflammatory properties. Poor sleep quality has been associated as a potential risk factor for several malignancies, including head and neck cancers. The purpose of this study is to determine salivary melatonin (MLT) levels in oral squamous cell carcinoma (OSCC) patients, compare the salivary MLT levels with those in healthy individuals and compare the salivary and serum levels in OSCC patients. Furthermore, the aim is to investigate the potential relationship between sleep quality and salivary MLT levels in OSCC patients. Unstimulated (UWS) and stimulated (SWS) whole saliva was sampled from patients with T1N0M0 and T2N0M0 OSCC (N = 34) and 33 sex and age matched healthy subjects. Serum samples were taken from 11 OSCC patients. Sleep quality was measured using Pittsburgh Sleep Quality Index (PSQI) questionnaire. Melatonin levels in UWS and SWS were significantly higher in the OSCC group. Sleep quality was significantly lower in patients with OSCC (P = 0.0001). ROC analysis was found to be significant (P < 0.001) in evaluating MLT concentration limit in diagnosing OSCC. The expected relationship between sleep quality and salivary MLT levels in OSCC patients was not observed. Our results suggest salivary MLT as a potential biomarker that might facilitate non-invasive detection of early stage OSCC.Ivan SalarićIvana KarmelićJasna LovrićKsenija BaždarićMarko RožmanIgor ČvrljevićIvan ZajcDavor BrajdićDarko MacanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ivan Salarić Ivana Karmelić Jasna Lovrić Ksenija Baždarić Marko Rožman Igor Čvrljević Ivan Zajc Davor Brajdić Darko Macan Salivary melatonin in oral squamous cell carcinoma patients
description	Abstract Melatonin’s role in circadian rhythm is well documented, as are its’ anti-oxidant, oncostatic and anti-inflammatory properties. Poor sleep quality has been associated as a potential risk factor for several malignancies, including head and neck cancers. The purpose of this study is to determine salivary melatonin (MLT) levels in oral squamous cell carcinoma (OSCC) patients, compare the salivary MLT levels with those in healthy individuals and compare the salivary and serum levels in OSCC patients. Furthermore, the aim is to investigate the potential relationship between sleep quality and salivary MLT levels in OSCC patients. Unstimulated (UWS) and stimulated (SWS) whole saliva was sampled from patients with T1N0M0 and T2N0M0 OSCC (N = 34) and 33 sex and age matched healthy subjects. Serum samples were taken from 11 OSCC patients. Sleep quality was measured using Pittsburgh Sleep Quality Index (PSQI) questionnaire. Melatonin levels in UWS and SWS were significantly higher in the OSCC group. Sleep quality was significantly lower in patients with OSCC (P = 0.0001). ROC analysis was found to be significant (P < 0.001) in evaluating MLT concentration limit in diagnosing OSCC. The expected relationship between sleep quality and salivary MLT levels in OSCC patients was not observed. Our results suggest salivary MLT as a potential biomarker that might facilitate non-invasive detection of early stage OSCC.
format	article
author	Ivan Salarić Ivana Karmelić Jasna Lovrić Ksenija Baždarić Marko Rožman Igor Čvrljević Ivan Zajc Davor Brajdić Darko Macan
author_facet	Ivan Salarić Ivana Karmelić Jasna Lovrić Ksenija Baždarić Marko Rožman Igor Čvrljević Ivan Zajc Davor Brajdić Darko Macan
author_sort	Ivan Salarić
title	Salivary melatonin in oral squamous cell carcinoma patients
title_short	Salivary melatonin in oral squamous cell carcinoma patients
title_full	Salivary melatonin in oral squamous cell carcinoma patients
title_fullStr	Salivary melatonin in oral squamous cell carcinoma patients
title_full_unstemmed	Salivary melatonin in oral squamous cell carcinoma patients
title_sort	salivary melatonin in oral squamous cell carcinoma patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/248617a206d640768138e1f2e54309d2
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Salivary melatonin in oral squamous cell carcinoma patients

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