A history of chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru.
<h4>Background</h4>The history of Chagas disease control in Peru and many other nations is marked by scattered and poorly documented vector control campaigns. The complexities of human migration and sporadic control campaigns complicate evaluation of the burden of Chagas disease and dyna...
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oai:doaj.org-article:248cba869b1a4d7aa790f27f437145542021-11-18T09:13:33ZA history of chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru.1935-27271935-273510.1371/journal.pntd.0000970https://doaj.org/article/248cba869b1a4d7aa790f27f437145542011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21364970/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>The history of Chagas disease control in Peru and many other nations is marked by scattered and poorly documented vector control campaigns. The complexities of human migration and sporadic control campaigns complicate evaluation of the burden of Chagas disease and dynamics of Trypanosoma cruzi transmission.<h4>Methodology/principal findings</h4>We conducted a cross-sectional serological and entomological study to evaluate temporal and spatial patterns of T. cruzi transmission in a peri-rural region of La Joya, Peru. We use a multivariate catalytic model and Bayesian methods to estimate incidence of infection over time and thereby elucidate the complex history of transmission in the area. Of 1,333 study participants, 101 (7.6%; 95% CI: 6.2-9.0%) were confirmed T. cruzi seropositive. Spatial clustering of parasitic infection was found in vector insects, but not in human cases. Expanded catalytic models suggest that transmission was interrupted in the study area in 1996 (95% credible interval: 1991-2000), with a resultant decline in the average annual incidence of infection from 0.9% (95% credible interval: 0.6-1.3%) to 0.1% (95% credible interval: 0.005-0.3%). Through a search of archival newspaper reports, we uncovered documentation of a 1995 vector control campaign, and thereby independently validated the model estimates.<h4>Conclusions/significance</h4>High levels of T. cruzi transmission had been ongoing in peri-rural La Joya prior to interruption of parasite transmission through a little-documented vector control campaign in 1995. Despite the efficacy of the 1995 control campaign, T. cruzi was rapidly reemerging in vector populations in La Joya, emphasizing the need for continuing surveillance and control at the rural-urban interface.Stephen DelgadoRicardo Castillo NeyraVíctor R Quispe MachacaJenny Ancca JuárezLily Chou ChuManuela Renee VerasteguiGiovanna M Moscoso ApazaCésar D BocángelAaron W TustinCharles R SterlingAndrew C ComrieCésar NáquiraJuan G Cornejo del CarpioRobert H GilmanCaryn BernMichael Z LevyPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e970 (2011) |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
| spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Stephen Delgado Ricardo Castillo Neyra Víctor R Quispe Machaca Jenny Ancca Juárez Lily Chou Chu Manuela Renee Verastegui Giovanna M Moscoso Apaza César D Bocángel Aaron W Tustin Charles R Sterling Andrew C Comrie César Náquira Juan G Cornejo del Carpio Robert H Gilman Caryn Bern Michael Z Levy A history of chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. |
| description |
<h4>Background</h4>The history of Chagas disease control in Peru and many other nations is marked by scattered and poorly documented vector control campaigns. The complexities of human migration and sporadic control campaigns complicate evaluation of the burden of Chagas disease and dynamics of Trypanosoma cruzi transmission.<h4>Methodology/principal findings</h4>We conducted a cross-sectional serological and entomological study to evaluate temporal and spatial patterns of T. cruzi transmission in a peri-rural region of La Joya, Peru. We use a multivariate catalytic model and Bayesian methods to estimate incidence of infection over time and thereby elucidate the complex history of transmission in the area. Of 1,333 study participants, 101 (7.6%; 95% CI: 6.2-9.0%) were confirmed T. cruzi seropositive. Spatial clustering of parasitic infection was found in vector insects, but not in human cases. Expanded catalytic models suggest that transmission was interrupted in the study area in 1996 (95% credible interval: 1991-2000), with a resultant decline in the average annual incidence of infection from 0.9% (95% credible interval: 0.6-1.3%) to 0.1% (95% credible interval: 0.005-0.3%). Through a search of archival newspaper reports, we uncovered documentation of a 1995 vector control campaign, and thereby independently validated the model estimates.<h4>Conclusions/significance</h4>High levels of T. cruzi transmission had been ongoing in peri-rural La Joya prior to interruption of parasite transmission through a little-documented vector control campaign in 1995. Despite the efficacy of the 1995 control campaign, T. cruzi was rapidly reemerging in vector populations in La Joya, emphasizing the need for continuing surveillance and control at the rural-urban interface. |
| format |
article |
| author |
Stephen Delgado Ricardo Castillo Neyra Víctor R Quispe Machaca Jenny Ancca Juárez Lily Chou Chu Manuela Renee Verastegui Giovanna M Moscoso Apaza César D Bocángel Aaron W Tustin Charles R Sterling Andrew C Comrie César Náquira Juan G Cornejo del Carpio Robert H Gilman Caryn Bern Michael Z Levy |
| author_facet |
Stephen Delgado Ricardo Castillo Neyra Víctor R Quispe Machaca Jenny Ancca Juárez Lily Chou Chu Manuela Renee Verastegui Giovanna M Moscoso Apaza César D Bocángel Aaron W Tustin Charles R Sterling Andrew C Comrie César Náquira Juan G Cornejo del Carpio Robert H Gilman Caryn Bern Michael Z Levy |
| author_sort |
Stephen Delgado |
| title |
A history of chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. |
| title_short |
A history of chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. |
| title_full |
A history of chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. |
| title_fullStr |
A history of chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. |
| title_full_unstemmed |
A history of chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. |
| title_sort |
history of chagas disease transmission, control, and re-emergence in peri-rural la joya, peru. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/248cba869b1a4d7aa790f27f43714554 |
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