Functional redundancy of the premotor network in hemispherotomy patients

Abstract Objective Using multimodal imaging, we tested the hypothesis that patients after hemispherotomy recruit non‐primary motor areas and non‐pyramidal descending motor fibers to restore motor function of the impaired limb. Methods Functional and structural MRI data were acquired in a group of 25...

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Autores principales:	Conrad C. Prillwitz, Bastian David, Gottfried Schlaug, Thomas Deller, Johannes Schramm, Robert Lindenberg, Elke Hattingen, Bernd Weber, Rainer Surges, Christian E. Elger, Theodor Rüber
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/248cf770f9dd43a0b0802f6650e038fe
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spelling	oai:doaj.org-article:248cf770f9dd43a0b0802f6650e038fe2021-11-19T13:55:31ZFunctional redundancy of the premotor network in hemispherotomy patients2328-950310.1002/acn3.51427https://doaj.org/article/248cf770f9dd43a0b0802f6650e038fe2021-09-01T00:00:00Zhttps://doi.org/10.1002/acn3.51427https://doaj.org/toc/2328-9503Abstract Objective Using multimodal imaging, we tested the hypothesis that patients after hemispherotomy recruit non‐primary motor areas and non‐pyramidal descending motor fibers to restore motor function of the impaired limb. Methods Functional and structural MRI data were acquired in a group of 25 patients who had undergone hemispherotomy and in a matched group of healthy controls. Patients’ motor impairment was measured using the Fugl‐Meyer Motor Assessment. Cortical areas governing upper extremity motor‐control were identified by task‐based functional MRI. The resulting areas were used as nodes for functional and structural connectivity analyses. Results In hemispherotomy patients, movement of the impaired upper extremity was associated to widespread activation of non‐primary premotor areas, whereas movement of the unimpaired one and of the control group related to activations prevalently located in the primary motor cortex (all p ≤ 0.05, FWE‐corrected). Non‐pyramidal tracts originating in premotor/supplementary motor areas and descending through the pontine tegmentum showed relatively higher structural connectivity in patients (p < 0.001, FWE‐corrected). Significant correlations between structural connectivity and motor impairment were found for non‐pyramidal (p = 0.023, FWE‐corrected), but not for pyramidal connections. Interpretation A premotor/supplementary motor network and non‐pyramidal fibers seem to mediate motor function in patients after hemispherotomy. In case of hemispheric lesion, the homologous regions in the contralesional hemisphere may not compensate the resulting motor deficit, but the functionally redundant premotor network.Conrad C. PrillwitzBastian DavidGottfried SchlaugThomas DellerJohannes SchrammRobert LindenbergElke HattingenBernd WeberRainer SurgesChristian E. ElgerTheodor RüberWileyarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENAnnals of Clinical and Translational Neurology, Vol 8, Iss 9, Pp 1796-1808 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Conrad C. Prillwitz Bastian David Gottfried Schlaug Thomas Deller Johannes Schramm Robert Lindenberg Elke Hattingen Bernd Weber Rainer Surges Christian E. Elger Theodor Rüber Functional redundancy of the premotor network in hemispherotomy patients
description	Abstract Objective Using multimodal imaging, we tested the hypothesis that patients after hemispherotomy recruit non‐primary motor areas and non‐pyramidal descending motor fibers to restore motor function of the impaired limb. Methods Functional and structural MRI data were acquired in a group of 25 patients who had undergone hemispherotomy and in a matched group of healthy controls. Patients’ motor impairment was measured using the Fugl‐Meyer Motor Assessment. Cortical areas governing upper extremity motor‐control were identified by task‐based functional MRI. The resulting areas were used as nodes for functional and structural connectivity analyses. Results In hemispherotomy patients, movement of the impaired upper extremity was associated to widespread activation of non‐primary premotor areas, whereas movement of the unimpaired one and of the control group related to activations prevalently located in the primary motor cortex (all p ≤ 0.05, FWE‐corrected). Non‐pyramidal tracts originating in premotor/supplementary motor areas and descending through the pontine tegmentum showed relatively higher structural connectivity in patients (p < 0.001, FWE‐corrected). Significant correlations between structural connectivity and motor impairment were found for non‐pyramidal (p = 0.023, FWE‐corrected), but not for pyramidal connections. Interpretation A premotor/supplementary motor network and non‐pyramidal fibers seem to mediate motor function in patients after hemispherotomy. In case of hemispheric lesion, the homologous regions in the contralesional hemisphere may not compensate the resulting motor deficit, but the functionally redundant premotor network.
format	article
author	Conrad C. Prillwitz Bastian David Gottfried Schlaug Thomas Deller Johannes Schramm Robert Lindenberg Elke Hattingen Bernd Weber Rainer Surges Christian E. Elger Theodor Rüber
author_facet	Conrad C. Prillwitz Bastian David Gottfried Schlaug Thomas Deller Johannes Schramm Robert Lindenberg Elke Hattingen Bernd Weber Rainer Surges Christian E. Elger Theodor Rüber
author_sort	Conrad C. Prillwitz
title	Functional redundancy of the premotor network in hemispherotomy patients
title_short	Functional redundancy of the premotor network in hemispherotomy patients
title_full	Functional redundancy of the premotor network in hemispherotomy patients
title_fullStr	Functional redundancy of the premotor network in hemispherotomy patients
title_full_unstemmed	Functional redundancy of the premotor network in hemispherotomy patients
title_sort	functional redundancy of the premotor network in hemispherotomy patients
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/248cf770f9dd43a0b0802f6650e038fe
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Functional redundancy of the premotor network in hemispherotomy patients

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