The Interactome in the Evolution From Frailty to Sarcopenic Dependence
Biomarkers are essential tools for accurate diagnosis and effective prevention, but their validation is a pending challenge that limits their usefulness, even more so with constructs as complex as frailty. Sarcopenia shares multiple mechanisms with frailty which makes it a strong candidate to provid...
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2021
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oai:doaj.org-article:249024b39f554ecd9d763f1ed13edb522021-12-02T16:44:39ZThe Interactome in the Evolution From Frailty to Sarcopenic Dependence2296-634X10.3389/fcell.2021.792825https://doaj.org/article/249024b39f554ecd9d763f1ed13edb522021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.792825/fullhttps://doaj.org/toc/2296-634XBiomarkers are essential tools for accurate diagnosis and effective prevention, but their validation is a pending challenge that limits their usefulness, even more so with constructs as complex as frailty. Sarcopenia shares multiple mechanisms with frailty which makes it a strong candidate to provide robust frailty biomarkers. Based on this premise, we studied the temporal evolution of cellular interactome in frailty, from independent patients to dependent ones. Overweight is a recognized cause of frailty in aging, so we studied the altered mechanisms in overweight independent elderly and evaluated their aggravation in dependent elderly. This evidence of the evolution of previously altered mechanisms would significantly support their role as real biomarkers of frailty. The results showed a preponderant role of autophagy in interactome control at both different functional points, modulating other essential mechanisms in the cell, such as mitochondrial capacity or oxidative stress. Thus, the overweight provoked in the muscle of the elderly an overload of autophagy that kept cell survival in apparently healthy individuals. This excessive and permanent autophagic effort did not seem to be able to be maintained over time. Indeed, in dependent elderly, the muscle showed a total autophagic inactivity, with devastating effects on the survival of the cell, which showed clear signs of apoptosis, and reduced functional capacity. The frail elderly are in a situation of weakness that is a precursor of dependence that can still be prevented if detection is early. Hence biomarkers are essential in this context.Ana Coto-MontesAna Coto-MontesAna Coto-MontesLaura González-BlancoEduardo AntuñaEduardo AntuñaEduardo AntuñaIván Menéndez-ValleIván Menéndez-ValleIván Menéndez-ValleJuan Carlos Bermejo-MilloJuan Carlos Bermejo-MilloJuan Carlos Bermejo-MilloBeatriz CaballeroBeatriz CaballeroBeatriz CaballeroIgnacio Vega-NaredoIgnacio Vega-NaredoIgnacio Vega-NaredoYaiza PotesYaiza PotesYaiza PotesFrontiers Media S.A.articlefrailtydependencesarcopeniaskeletal muscleinteractomebiomarkersBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
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| collection |
DOAJ |
| language |
EN |
| topic |
frailty dependence sarcopenia skeletal muscle interactome biomarkers Biology (General) QH301-705.5 |
| spellingShingle |
frailty dependence sarcopenia skeletal muscle interactome biomarkers Biology (General) QH301-705.5 Ana Coto-Montes Ana Coto-Montes Ana Coto-Montes Laura González-Blanco Eduardo Antuña Eduardo Antuña Eduardo Antuña Iván Menéndez-Valle Iván Menéndez-Valle Iván Menéndez-Valle Juan Carlos Bermejo-Millo Juan Carlos Bermejo-Millo Juan Carlos Bermejo-Millo Beatriz Caballero Beatriz Caballero Beatriz Caballero Ignacio Vega-Naredo Ignacio Vega-Naredo Ignacio Vega-Naredo Yaiza Potes Yaiza Potes Yaiza Potes The Interactome in the Evolution From Frailty to Sarcopenic Dependence |
| description |
Biomarkers are essential tools for accurate diagnosis and effective prevention, but their validation is a pending challenge that limits their usefulness, even more so with constructs as complex as frailty. Sarcopenia shares multiple mechanisms with frailty which makes it a strong candidate to provide robust frailty biomarkers. Based on this premise, we studied the temporal evolution of cellular interactome in frailty, from independent patients to dependent ones. Overweight is a recognized cause of frailty in aging, so we studied the altered mechanisms in overweight independent elderly and evaluated their aggravation in dependent elderly. This evidence of the evolution of previously altered mechanisms would significantly support their role as real biomarkers of frailty. The results showed a preponderant role of autophagy in interactome control at both different functional points, modulating other essential mechanisms in the cell, such as mitochondrial capacity or oxidative stress. Thus, the overweight provoked in the muscle of the elderly an overload of autophagy that kept cell survival in apparently healthy individuals. This excessive and permanent autophagic effort did not seem to be able to be maintained over time. Indeed, in dependent elderly, the muscle showed a total autophagic inactivity, with devastating effects on the survival of the cell, which showed clear signs of apoptosis, and reduced functional capacity. The frail elderly are in a situation of weakness that is a precursor of dependence that can still be prevented if detection is early. Hence biomarkers are essential in this context. |
| format |
article |
| author |
Ana Coto-Montes Ana Coto-Montes Ana Coto-Montes Laura González-Blanco Eduardo Antuña Eduardo Antuña Eduardo Antuña Iván Menéndez-Valle Iván Menéndez-Valle Iván Menéndez-Valle Juan Carlos Bermejo-Millo Juan Carlos Bermejo-Millo Juan Carlos Bermejo-Millo Beatriz Caballero Beatriz Caballero Beatriz Caballero Ignacio Vega-Naredo Ignacio Vega-Naredo Ignacio Vega-Naredo Yaiza Potes Yaiza Potes Yaiza Potes |
| author_facet |
Ana Coto-Montes Ana Coto-Montes Ana Coto-Montes Laura González-Blanco Eduardo Antuña Eduardo Antuña Eduardo Antuña Iván Menéndez-Valle Iván Menéndez-Valle Iván Menéndez-Valle Juan Carlos Bermejo-Millo Juan Carlos Bermejo-Millo Juan Carlos Bermejo-Millo Beatriz Caballero Beatriz Caballero Beatriz Caballero Ignacio Vega-Naredo Ignacio Vega-Naredo Ignacio Vega-Naredo Yaiza Potes Yaiza Potes Yaiza Potes |
| author_sort |
Ana Coto-Montes |
| title |
The Interactome in the Evolution From Frailty to Sarcopenic Dependence |
| title_short |
The Interactome in the Evolution From Frailty to Sarcopenic Dependence |
| title_full |
The Interactome in the Evolution From Frailty to Sarcopenic Dependence |
| title_fullStr |
The Interactome in the Evolution From Frailty to Sarcopenic Dependence |
| title_full_unstemmed |
The Interactome in the Evolution From Frailty to Sarcopenic Dependence |
| title_sort |
interactome in the evolution from frailty to sarcopenic dependence |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/249024b39f554ecd9d763f1ed13edb52 |
| work_keys_str_mv |
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