Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium

Cadmium is a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into...

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Autores principales:	Hernayanti Hernayanti, Sri Lestari, Saryono Saryono, Puji Lestari
Formato:	article
Lenguaje:	EN ID
Publicado:	Jenderal Soedirman University 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2494e56c2cd948a79b79935d5afcc247
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spelling	oai:doaj.org-article:2494e56c2cd948a79b79935d5afcc2472021-11-22T01:13:54ZAnti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium1907-97612503-031010.20884/1.jm.2021.16.3.775https://doaj.org/article/2494e56c2cd948a79b79935d5afcc2472021-11-01T00:00:00Zhttps://ojs.jmolekul.com/ojs/index.php/jm/article/view/775https://doaj.org/toc/1907-9761https://doaj.org/toc/2503-0310Cadmium is a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups with four replications, i.e group of healthy control (C1), negative control induced by CdSO4 with dosage 56 mg/kg for 14 days and treatment (C3-C6) with dosage of 100, 200 ,300 and 400 mg/kg of C. asiatica. The blood Cd, GST, GSH, TNF- α and COx2 were measured after a 21 days administration of C. asiatica. The data were analyzed by ANOVA test followed by Duncan test with a significance level of 5%. The result showed that administrating C.asiatica can neutralized cadmium, improve inflammation in liver.The conclusion of our research that C.asiatica extract can decrease Cd level, TNF-α and COx2 levels and increase GST and GSH level in rat induced by cadmium. A 200 mg/kg was the effective dosage to reduce Cd, TNF-α and COx2 levels and increase GST and GSH levels. Key words : anti inflammatory, Cd, Centella asiatica, GST, COX2Hernayanti HernayantiSri LestariSaryono SaryonoPuji LestariJenderal Soedirman UniversityarticleChemistryQD1-999ENIDMolekul, Vol 16, Iss 3, Pp 200-207 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Hernayanti Hernayanti Sri Lestari Saryono Saryono Puji Lestari Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium
description	Cadmium is a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups with four replications, i.e group of healthy control (C1), negative control induced by CdSO4 with dosage 56 mg/kg for 14 days and treatment (C3-C6) with dosage of 100, 200 ,300 and 400 mg/kg of C. asiatica. The blood Cd, GST, GSH, TNF- α and COx2 were measured after a 21 days administration of C. asiatica. The data were analyzed by ANOVA test followed by Duncan test with a significance level of 5%. The result showed that administrating C.asiatica can neutralized cadmium, improve inflammation in liver.The conclusion of our research that C.asiatica extract can decrease Cd level, TNF-α and COx2 levels and increase GST and GSH level in rat induced by cadmium. A 200 mg/kg was the effective dosage to reduce Cd, TNF-α and COx2 levels and increase GST and GSH levels. Key words : anti inflammatory, Cd, Centella asiatica, GST, COX2
format	article
author	Hernayanti Hernayanti Sri Lestari Saryono Saryono Puji Lestari
author_facet	Hernayanti Hernayanti Sri Lestari Saryono Saryono Puji Lestari
author_sort	Hernayanti Hernayanti
title	Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium
title_short	Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium
title_full	Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium
title_fullStr	Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium
title_full_unstemmed	Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium
title_sort	anti-inflammatory test of centella asiatica extract on rat induced by cadmium
publisher	Jenderal Soedirman University
publishDate	2021
url	https://doaj.org/article/2494e56c2cd948a79b79935d5afcc247
work_keys_str_mv	AT hernayantihernayanti antiinflammatorytestofcentellaasiaticaextractonratinducedbycadmium AT srilestari antiinflammatorytestofcentellaasiaticaextractonratinducedbycadmium AT saryonosaryono antiinflammatorytestofcentellaasiaticaextractonratinducedbycadmium AT pujilestari antiinflammatorytestofcentellaasiaticaextractonratinducedbycadmium
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Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium

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