Risperidone treatment for ADHD in children and adolescents with bipolar disorder

Joseph Biederman, Paul Hammerness, Robert Doyle, Gagan Joshi, Megan Aleardi, Eric MickPediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, MA, USAObjective: Children and adolescents with bipolar disorder are also at high risk of having comorbid attention-deficit...

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Autores principales:	Joseph Biederman, Paul Hammerness, Robert Doyle, Gagan Joshi, Megan Aleardi, Eric Mick
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/24957c38ae5f4f7886f609075aebb447
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spelling	oai:doaj.org-article:24957c38ae5f4f7886f609075aebb4472021-12-02T00:51:09ZRisperidone treatment for ADHD in children and adolescents with bipolar disorder1176-63281178-2021https://doaj.org/article/24957c38ae5f4f7886f609075aebb4472008-03-01T00:00:00Zhttp://www.dovepress.com/risperidone-treatment-for-adhd-in-children-and-adolescents-with-bipola-a986https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Joseph Biederman, Paul Hammerness, Robert Doyle, Gagan Joshi, Megan Aleardi, Eric MickPediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, MA, USAObjective: Children and adolescents with bipolar disorder are also at high risk of having comorbid attention-deficit hyperactivity disorder (ADHD). The objective of this study was to estimate improvement in ADHD symptoms in children with bipolar disorder.Methods: This was an open-label, study of risperidone monotherapy for the treatment of pediatric bipolar disorder. Thirty-one children and adolescents 4&ndash;15 years of age (7.2 &plusmn; 2.8 years) of both sexes (71%, N = 22 male) with pediatric bipolar disorder (YMRS score = 32.9 &plusmn; 8.8) and ADHD (ADHD-RS score = 37.9 &plusmn; 8.9) were included in these analyses.Results: Improvement in ADHD symptoms was contingent on improvement in manic symptoms. Although both hyperactive/impulsive (&minus;7.5 &plusmn; 5.5.6, p &lt; 0.05) and inattentive (&minus;6.8 &plusmn; 5.0, p &lt; 0.05) ADHD symptoms were significantly improved with risperidone, improvement was modest, and only 29% of subjects (N = 6) showed a 30% reduction in ADHD rating scale scores and had a CGI-I&nbsp;&le; 2.Conclusions: These results suggest that that treatment with risperidone is associated with tangible but generally modest improvement of symptoms of ADHD in children with bipolar disorder.Keywords: ADHD, bipolar disorder, children, risperidone Joseph BiedermanPaul HammernessRobert DoyleGagan JoshiMegan AleardiEric MickDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 203-207 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Joseph Biederman Paul Hammerness Robert Doyle Gagan Joshi Megan Aleardi Eric Mick Risperidone treatment for ADHD in children and adolescents with bipolar disorder
description	Joseph Biederman, Paul Hammerness, Robert Doyle, Gagan Joshi, Megan Aleardi, Eric MickPediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, MA, USAObjective: Children and adolescents with bipolar disorder are also at high risk of having comorbid attention-deficit hyperactivity disorder (ADHD). The objective of this study was to estimate improvement in ADHD symptoms in children with bipolar disorder.Methods: This was an open-label, study of risperidone monotherapy for the treatment of pediatric bipolar disorder. Thirty-one children and adolescents 4&ndash;15 years of age (7.2 &plusmn; 2.8 years) of both sexes (71%, N = 22 male) with pediatric bipolar disorder (YMRS score = 32.9 &plusmn; 8.8) and ADHD (ADHD-RS score = 37.9 &plusmn; 8.9) were included in these analyses.Results: Improvement in ADHD symptoms was contingent on improvement in manic symptoms. Although both hyperactive/impulsive (&minus;7.5 &plusmn; 5.5.6, p &lt; 0.05) and inattentive (&minus;6.8 &plusmn; 5.0, p &lt; 0.05) ADHD symptoms were significantly improved with risperidone, improvement was modest, and only 29% of subjects (N = 6) showed a 30% reduction in ADHD rating scale scores and had a CGI-I&nbsp;&le; 2.Conclusions: These results suggest that that treatment with risperidone is associated with tangible but generally modest improvement of symptoms of ADHD in children with bipolar disorder.Keywords: ADHD, bipolar disorder, children, risperidone
format	article
author	Joseph Biederman Paul Hammerness Robert Doyle Gagan Joshi Megan Aleardi Eric Mick
author_facet	Joseph Biederman Paul Hammerness Robert Doyle Gagan Joshi Megan Aleardi Eric Mick
author_sort	Joseph Biederman
title	Risperidone treatment for ADHD in children and adolescents with bipolar disorder
title_short	Risperidone treatment for ADHD in children and adolescents with bipolar disorder
title_full	Risperidone treatment for ADHD in children and adolescents with bipolar disorder
title_fullStr	Risperidone treatment for ADHD in children and adolescents with bipolar disorder
title_full_unstemmed	Risperidone treatment for ADHD in children and adolescents with bipolar disorder
title_sort	risperidone treatment for adhd in children and adolescents with bipolar disorder
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/24957c38ae5f4f7886f609075aebb447
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Risperidone treatment for ADHD in children and adolescents with bipolar disorder

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