Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot

Abstract We used 4D-flow MRI to investigate circulation, an area integral of vorticity, in the main pulmonary artery (MPA) as a new hemodynamic parameter for assessing patients with a repaired Tetralogy of Fallot (TOF). We evaluated the relationship between circulation, right ventricular (RV) functi...

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Autores principales:	Nanae Tsuchiya, Michinobu Nagao, Yumi Shiina, Shohei Miyazaki, Kei Inai, Sadayuki Murayama, Shuji Sakai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/249592fd30f04e99bfcc3a719fbbb0a1
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spelling	oai:doaj.org-article:249592fd30f04e99bfcc3a719fbbb0a12021-12-02T18:25:03ZCirculation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot10.1038/s41598-021-91125-22045-2322https://doaj.org/article/249592fd30f04e99bfcc3a719fbbb0a12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91125-2https://doaj.org/toc/2045-2322Abstract We used 4D-flow MRI to investigate circulation, an area integral of vorticity, in the main pulmonary artery (MPA) as a new hemodynamic parameter for assessing patients with a repaired Tetralogy of Fallot (TOF). We evaluated the relationship between circulation, right ventricular (RV) function and the pulmonary regurgitant fraction (PRF). Twenty patients with a repaired TOF underwent cardiac MRI. Flow-sensitive 3D-gradient sequences were used to obtain 4D-flow images. Vortex formation in the MPA was visualized, with short-axis and longitudinal vorticities calculated by software specialized for 4D flow. The RV indexed end-diastolic/end-systolic volumes (RVEDVi/RVESVi) and RV ejection fraction (RVEF) were measured by cine MRI. The PR fraction (PRF) and MPA area were measured by 2D phase-contrast MRI. Spearman ρ values were determined to assess the relationships between circulation, RV function, and PRF. Vortex formation in the MPA occurred in 15 of 20 patients (75%). The longitudinal circulation (11.7 ± 5.1 m2/s) was correlated with the RVEF (ρ = − 0.85, p = 0.0002), RVEDVi (ρ = 0.62, p = 0.03), and RVESVi (ρ = 0.76, p = 0.003) after adjusting for the MPA size. The short-axis circulation (9.4 ± 3.4 m2/s) in the proximal MPA was positively correlated with the MPA area (ρ = 0.61, p = 0.004). The relationships between the PRF and circulation or RV function were not significant. Increased longitudinal circulation in the MPA, as demonstrated by circulation analysis using 4D flow MRI, was related to RV dysfunction in patients with a repaired TOF.Nanae TsuchiyaMichinobu NagaoYumi ShiinaShohei MiyazakiKei InaiSadayuki MurayamaShuji SakaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nanae Tsuchiya Michinobu Nagao Yumi Shiina Shohei Miyazaki Kei Inai Sadayuki Murayama Shuji Sakai Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot
description	Abstract We used 4D-flow MRI to investigate circulation, an area integral of vorticity, in the main pulmonary artery (MPA) as a new hemodynamic parameter for assessing patients with a repaired Tetralogy of Fallot (TOF). We evaluated the relationship between circulation, right ventricular (RV) function and the pulmonary regurgitant fraction (PRF). Twenty patients with a repaired TOF underwent cardiac MRI. Flow-sensitive 3D-gradient sequences were used to obtain 4D-flow images. Vortex formation in the MPA was visualized, with short-axis and longitudinal vorticities calculated by software specialized for 4D flow. The RV indexed end-diastolic/end-systolic volumes (RVEDVi/RVESVi) and RV ejection fraction (RVEF) were measured by cine MRI. The PR fraction (PRF) and MPA area were measured by 2D phase-contrast MRI. Spearman ρ values were determined to assess the relationships between circulation, RV function, and PRF. Vortex formation in the MPA occurred in 15 of 20 patients (75%). The longitudinal circulation (11.7 ± 5.1 m2/s) was correlated with the RVEF (ρ = − 0.85, p = 0.0002), RVEDVi (ρ = 0.62, p = 0.03), and RVESVi (ρ = 0.76, p = 0.003) after adjusting for the MPA size. The short-axis circulation (9.4 ± 3.4 m2/s) in the proximal MPA was positively correlated with the MPA area (ρ = 0.61, p = 0.004). The relationships between the PRF and circulation or RV function were not significant. Increased longitudinal circulation in the MPA, as demonstrated by circulation analysis using 4D flow MRI, was related to RV dysfunction in patients with a repaired TOF.
format	article
author	Nanae Tsuchiya Michinobu Nagao Yumi Shiina Shohei Miyazaki Kei Inai Sadayuki Murayama Shuji Sakai
author_facet	Nanae Tsuchiya Michinobu Nagao Yumi Shiina Shohei Miyazaki Kei Inai Sadayuki Murayama Shuji Sakai
author_sort	Nanae Tsuchiya
title	Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot
title_short	Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot
title_full	Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot
title_fullStr	Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot
title_full_unstemmed	Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot
title_sort	circulation derived from 4d flow mri correlates with right ventricular dysfunction in patients with tetralogy of fallot
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/249592fd30f04e99bfcc3a719fbbb0a1
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Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot

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