THE EFFECT OF DIAZINON ON THE LEYDIG CELLS AND THE LEVEL OF SEX HORMONES IN MICE

BACKGROUND AND OBJECTIVE: Diazinon (DZN) is an organophosphate pesticide which widely used in agriculture. The exposure to this pesticide could be resulted in damages of the living tissues. The present study was done to investigate the effects of diazinon on the leydig cells of testis and levels of...

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Autores principales:	E Fattahy, K Parivar, S.GH.A Jorsaraei, AK Moghaddamnia
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2007
Materias:	diazinon dzn leydig cells testosterone fsh lh Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/249ccc4019a54098a724e6c41a233521
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spelling	oai:doaj.org-article:249ccc4019a54098a724e6c41a2335212021-11-10T09:10:17ZTHE EFFECT OF DIAZINON ON THE LEYDIG CELLS AND THE LEVEL OF SEX HORMONES IN MICE1561-41072251-7170https://doaj.org/article/249ccc4019a54098a724e6c41a2335212007-10-01T00:00:00Zhttp://jbums.org/article-1-2517-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Diazinon (DZN) is an organophosphate pesticide which widely used in agriculture. The exposure to this pesticide could be resulted in damages of the living tissues. The present study was done to investigate the effects of diazinon on the leydig cells of testis and levels of sex hormones in the mice.METHODS: In this experimental study, 35 male mice divided into three groups. Control (no injection), Sham (water injection) and DZN group (30mg/kg i.p, five consecutive days per week for one month). Animals were killed 7 days after the latest injection. Blood samples were collected and testosterone, LH and FSH levels were assayed by radioimmunoassay. Testis tissues sections were provided to investigate the changes of leydig cells. Then data were analyzed.FINDINGS: The DZN (6.295±0.361) showed a significant decrease in the number of leydig cells compared with control and sham groups (11.37±0.769 and 11.26±0.347, respectively) (p=0.001) and subsequently decreased serum testosterone level in DZN group (3.68± 0.91) compared with control and sham groups (15.2±1.21 and 15.12±0.84, respectively) (p=0.001) but increased the levels of LH and FSH compared with control and sham groups.CONCLUSION: According to the results, it could be suggested that the DZN can exert a significant toxic effects on testis of mice. On the other hand, hormonal variations following DZN administration may be responsible for changes in infertility pattern in mice.E FattahyK ParivarS.GH.A Jorsaraei,AK MoghaddamniaBabol University of Medical Sciencesarticlediazinondznleydig cellstestosteronefshlhMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 9, Iss 4, Pp 15-22 (2007)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	diazinon dzn leydig cells testosterone fsh lh Medicine R Medicine (General) R5-920
spellingShingle	diazinon dzn leydig cells testosterone fsh lh Medicine R Medicine (General) R5-920 E Fattahy K Parivar S.GH.A Jorsaraei, AK Moghaddamnia THE EFFECT OF DIAZINON ON THE LEYDIG CELLS AND THE LEVEL OF SEX HORMONES IN MICE
description	BACKGROUND AND OBJECTIVE: Diazinon (DZN) is an organophosphate pesticide which widely used in agriculture. The exposure to this pesticide could be resulted in damages of the living tissues. The present study was done to investigate the effects of diazinon on the leydig cells of testis and levels of sex hormones in the mice.METHODS: In this experimental study, 35 male mice divided into three groups. Control (no injection), Sham (water injection) and DZN group (30mg/kg i.p, five consecutive days per week for one month). Animals were killed 7 days after the latest injection. Blood samples were collected and testosterone, LH and FSH levels were assayed by radioimmunoassay. Testis tissues sections were provided to investigate the changes of leydig cells. Then data were analyzed.FINDINGS: The DZN (6.295±0.361) showed a significant decrease in the number of leydig cells compared with control and sham groups (11.37±0.769 and 11.26±0.347, respectively) (p=0.001) and subsequently decreased serum testosterone level in DZN group (3.68± 0.91) compared with control and sham groups (15.2±1.21 and 15.12±0.84, respectively) (p=0.001) but increased the levels of LH and FSH compared with control and sham groups.CONCLUSION: According to the results, it could be suggested that the DZN can exert a significant toxic effects on testis of mice. On the other hand, hormonal variations following DZN administration may be responsible for changes in infertility pattern in mice.
format	article
author	E Fattahy K Parivar S.GH.A Jorsaraei, AK Moghaddamnia
author_facet	E Fattahy K Parivar S.GH.A Jorsaraei, AK Moghaddamnia
author_sort	E Fattahy
title	THE EFFECT OF DIAZINON ON THE LEYDIG CELLS AND THE LEVEL OF SEX HORMONES IN MICE
title_short	THE EFFECT OF DIAZINON ON THE LEYDIG CELLS AND THE LEVEL OF SEX HORMONES IN MICE
title_full	THE EFFECT OF DIAZINON ON THE LEYDIG CELLS AND THE LEVEL OF SEX HORMONES IN MICE
title_fullStr	THE EFFECT OF DIAZINON ON THE LEYDIG CELLS AND THE LEVEL OF SEX HORMONES IN MICE
title_full_unstemmed	THE EFFECT OF DIAZINON ON THE LEYDIG CELLS AND THE LEVEL OF SEX HORMONES IN MICE
title_sort	effect of diazinon on the leydig cells and the level of sex hormones in mice
publisher	Babol University of Medical Sciences
publishDate	2007
url	https://doaj.org/article/249ccc4019a54098a724e6c41a233521
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THE EFFECT OF DIAZINON ON THE LEYDIG CELLS AND THE LEVEL OF SEX HORMONES IN MICE

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