Fcmr regulates mononuclear phagocyte control of anti-tumor immunity

Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr – the putative receptor for soluble IgM – is a potent negative regulator of anti-tumour immunity.

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Autores principales:	Shawn P. Kubli, Larsen Vornholz, Gordon Duncan, Wenjing Zhou, Parameswaran Ramachandran, Jerome Fortin, Maureen Cox, SeongJun Han, Robert Nechanitzky, Duygu Nechanitzky, Bryan E. Snow, Lisa Jones, Wanda Y. Li, Jillian Haight, Andrew Wakeham, Mark R. Bray, Tak W. Mak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/249fbfe56ab6438d997eb47907be7294
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spelling	oai:doaj.org-article:249fbfe56ab6438d997eb47907be72942021-12-02T14:39:16ZFcmr regulates mononuclear phagocyte control of anti-tumor immunity10.1038/s41467-019-10619-w2041-1723https://doaj.org/article/249fbfe56ab6438d997eb47907be72942019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10619-whttps://doaj.org/toc/2041-1723Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr – the putative receptor for soluble IgM – is a potent negative regulator of anti-tumour immunity.Shawn P. KubliLarsen VornholzGordon DuncanWenjing ZhouParameswaran RamachandranJerome FortinMaureen CoxSeongJun HanRobert NechanitzkyDuygu NechanitzkyBryan E. SnowLisa JonesWanda Y. LiJillian HaightAndrew WakehamMark R. BrayTak W. MakNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shawn P. Kubli Larsen Vornholz Gordon Duncan Wenjing Zhou Parameswaran Ramachandran Jerome Fortin Maureen Cox SeongJun Han Robert Nechanitzky Duygu Nechanitzky Bryan E. Snow Lisa Jones Wanda Y. Li Jillian Haight Andrew Wakeham Mark R. Bray Tak W. Mak Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
description	Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr – the putative receptor for soluble IgM – is a potent negative regulator of anti-tumour immunity.
format	article
author	Shawn P. Kubli Larsen Vornholz Gordon Duncan Wenjing Zhou Parameswaran Ramachandran Jerome Fortin Maureen Cox SeongJun Han Robert Nechanitzky Duygu Nechanitzky Bryan E. Snow Lisa Jones Wanda Y. Li Jillian Haight Andrew Wakeham Mark R. Bray Tak W. Mak
author_facet	Shawn P. Kubli Larsen Vornholz Gordon Duncan Wenjing Zhou Parameswaran Ramachandran Jerome Fortin Maureen Cox SeongJun Han Robert Nechanitzky Duygu Nechanitzky Bryan E. Snow Lisa Jones Wanda Y. Li Jillian Haight Andrew Wakeham Mark R. Bray Tak W. Mak
author_sort	Shawn P. Kubli
title	Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
title_short	Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
title_full	Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
title_fullStr	Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
title_full_unstemmed	Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
title_sort	fcmr regulates mononuclear phagocyte control of anti-tumor immunity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/249fbfe56ab6438d997eb47907be7294
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Fcmr regulates mononuclear phagocyte control of anti-tumor immunity

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