Imaging Parkinson’s disease below the neck

Abstract Parkinson’s disease is a systemic disorder with widespread and early α-synuclein pathology in the autonomic and enteric nervous systems, which is present throughout the gastrointestinal canal prior to diagnosis. Gastrointestinal and genitourinary autonomic symptoms often predate clinical di...

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Autores principales:	Per Borghammer, Karoline Knudsen, Tatyana D. Fedorova, David J. Brooks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/249fd2b0e28c4fd5b87c65e384df4712
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spelling	oai:doaj.org-article:249fd2b0e28c4fd5b87c65e384df47122021-12-02T11:42:13ZImaging Parkinson’s disease below the neck10.1038/s41531-017-0017-12373-8057https://doaj.org/article/249fd2b0e28c4fd5b87c65e384df47122017-04-01T00:00:00Zhttps://doi.org/10.1038/s41531-017-0017-1https://doaj.org/toc/2373-8057Abstract Parkinson’s disease is a systemic disorder with widespread and early α-synuclein pathology in the autonomic and enteric nervous systems, which is present throughout the gastrointestinal canal prior to diagnosis. Gastrointestinal and genitourinary autonomic symptoms often predate clinical diagnosis by several years. It has been hypothesized that progressive α-synuclein aggregation is initiated in hyperbranched, non-myelinated neuron terminals, and may subsequently spread via retrograde axonal transport. This would explain why autonomic nerves are so prone to formation of α-synuclein pathology. However, the hypothesis remains unproven and in vivo imaging methods of peripheral organs may be essential to study this important research field. The loss of sympathetic and parasympathetic nerve terminal function in Parkinson’s disease has been demonstrated using radiotracers such as 123I-meta-iodobenzylguanidin, 18F-dopamine, and 11C-donepezil. Other radiotracer and radiological imaging methods have shown highly prevalent dysfunction of pharyngeal and esophageal motility, gastric emptying, colonic transit time, and anorectal function. Here, we summarize the methodology and main findings of radio-isotope and radiological modalities for imaging peripheral pathology in Parkinson’s disease.Per BorghammerKaroline KnudsenTatyana D. FedorovaDavid J. BrooksNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 3, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Per Borghammer Karoline Knudsen Tatyana D. Fedorova David J. Brooks Imaging Parkinson’s disease below the neck
description	Abstract Parkinson’s disease is a systemic disorder with widespread and early α-synuclein pathology in the autonomic and enteric nervous systems, which is present throughout the gastrointestinal canal prior to diagnosis. Gastrointestinal and genitourinary autonomic symptoms often predate clinical diagnosis by several years. It has been hypothesized that progressive α-synuclein aggregation is initiated in hyperbranched, non-myelinated neuron terminals, and may subsequently spread via retrograde axonal transport. This would explain why autonomic nerves are so prone to formation of α-synuclein pathology. However, the hypothesis remains unproven and in vivo imaging methods of peripheral organs may be essential to study this important research field. The loss of sympathetic and parasympathetic nerve terminal function in Parkinson’s disease has been demonstrated using radiotracers such as 123I-meta-iodobenzylguanidin, 18F-dopamine, and 11C-donepezil. Other radiotracer and radiological imaging methods have shown highly prevalent dysfunction of pharyngeal and esophageal motility, gastric emptying, colonic transit time, and anorectal function. Here, we summarize the methodology and main findings of radio-isotope and radiological modalities for imaging peripheral pathology in Parkinson’s disease.
format	article
author	Per Borghammer Karoline Knudsen Tatyana D. Fedorova David J. Brooks
author_facet	Per Borghammer Karoline Knudsen Tatyana D. Fedorova David J. Brooks
author_sort	Per Borghammer
title	Imaging Parkinson’s disease below the neck
title_short	Imaging Parkinson’s disease below the neck
title_full	Imaging Parkinson’s disease below the neck
title_fullStr	Imaging Parkinson’s disease below the neck
title_full_unstemmed	Imaging Parkinson’s disease below the neck
title_sort	imaging parkinson’s disease below the neck
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/249fd2b0e28c4fd5b87c65e384df4712
work_keys_str_mv	AT perborghammer imagingparkinsonsdiseasebelowtheneck AT karolineknudsen imagingparkinsonsdiseasebelowtheneck AT tatyanadfedorova imagingparkinsonsdiseasebelowtheneck AT davidjbrooks imagingparkinsonsdiseasebelowtheneck
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Imaging Parkinson’s disease below the neck

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