Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma

Abstract Several prognostic indicators have shown inconsistencies in patients of different genders with lung adenocarcinoma, indicating that these variations may be due to the different genetic background of males and females with lung adenocarcinoma. In this study, we first used the Gene-Cloud of B...

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Autores principales:	Jian Xiao, Aibin Liu, Xiaoxiao Lu, Xi Chen, Wei Li, Shuya He, Bixiu He, Qiong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24a47407c66146548d3056db7d64c19f
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spelling	oai:doaj.org-article:24a47407c66146548d3056db7d64c19f2021-12-02T16:06:16ZPrognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma10.1038/s41598-017-02290-22045-2322https://doaj.org/article/24a47407c66146548d3056db7d64c19f2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02290-2https://doaj.org/toc/2045-2322Abstract Several prognostic indicators have shown inconsistencies in patients of different genders with lung adenocarcinoma, indicating that these variations may be due to the different genetic background of males and females with lung adenocarcinoma. In this study, we first used the Gene-Cloud of Biotechnology Information (GCBI) bioinformatics platform to identify differentially expressed genes (DEGs) that eliminated gender differences between lung adenocarcinoma and normal lung tissues. Then, we screened out that transcription factor 21 (TCF21) is a hub gene among these DEGs by creating a gene co-expression network on the GCBI platform. Furthermore, we used the comprehensive survival analysis platforms Kaplan-Meier plotter and PrognoScan to assess the prognostic value of TCF21 expression in lung adenocarcinoma patients. Finally, we concluded that decreased mRNA expression of TCF21 is a predictor for poor prognosis in patients with lung adenocarcinoma.Jian XiaoAibin LiuXiaoxiao LuXi ChenWei LiShuya HeBixiu HeQiong ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Xiao Aibin Liu Xiaoxiao Lu Xi Chen Wei Li Shuya He Bixiu He Qiong Chen Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma
description	Abstract Several prognostic indicators have shown inconsistencies in patients of different genders with lung adenocarcinoma, indicating that these variations may be due to the different genetic background of males and females with lung adenocarcinoma. In this study, we first used the Gene-Cloud of Biotechnology Information (GCBI) bioinformatics platform to identify differentially expressed genes (DEGs) that eliminated gender differences between lung adenocarcinoma and normal lung tissues. Then, we screened out that transcription factor 21 (TCF21) is a hub gene among these DEGs by creating a gene co-expression network on the GCBI platform. Furthermore, we used the comprehensive survival analysis platforms Kaplan-Meier plotter and PrognoScan to assess the prognostic value of TCF21 expression in lung adenocarcinoma patients. Finally, we concluded that decreased mRNA expression of TCF21 is a predictor for poor prognosis in patients with lung adenocarcinoma.
format	article
author	Jian Xiao Aibin Liu Xiaoxiao Lu Xi Chen Wei Li Shuya He Bixiu He Qiong Chen
author_facet	Jian Xiao Aibin Liu Xiaoxiao Lu Xi Chen Wei Li Shuya He Bixiu He Qiong Chen
author_sort	Jian Xiao
title	Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma
title_short	Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma
title_full	Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma
title_fullStr	Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma
title_full_unstemmed	Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma
title_sort	prognostic significance of tcf21 mrna expression in patients with lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/24a47407c66146548d3056db7d64c19f
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_version_	1718385011531448320

Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma

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