Characterization of the serological biomarkers associated with Sjögren’s syndrome in patients with recalcitrant dry eye disease

Characterization of the serological biomarkers associated with Sjögren’s syndrome in patients with recalcitrant dry eye disease

Cynthia Matossian,1,2 Joan Micucci1 1Matossian Eye Associates, Doylestown, PA, USA; 2Department of Ophthalmology, Temple University School of Medicine, Philadelphia, PA, USA Purpose: The purpose was to characterize the biomarkers associated with Sjögren’s syndrome (SS)...

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Autores principales: Matossian C, Micucci J
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
Sjögren’s Syndrome
Dry Eye
Autoantibodies
Autoimmune
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/24a4f65176544330a5f84602d4e79a62
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spelling oai:doaj.org-article:24a4f65176544330a5f84602d4e79a622021-12-02T02:44:12ZCharacterization of the serological biomarkers associated with Sjögren’s syndrome in patients with recalcitrant dry eye disease1177-5483https://doaj.org/article/24a4f65176544330a5f84602d4e79a622016-07-01T00:00:00Zhttps://www.dovepress.com/characterization-of-the-serological-biomarkers-associated-with-sjoumlg-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Cynthia Matossian,1,2 Joan Micucci1 1Matossian Eye Associates, Doylestown, PA, USA; 2Department of Ophthalmology, Temple University School of Medicine, Philadelphia, PA, USA Purpose: The purpose was to characterize the biomarkers associated with Sjögren’s syndrome (SS) identified in the serological samples of patients with recalcitrant dry eye disease; additionally, the modalities utilized in the treatment of dry eye disease were evaluated for subsets of patients with and without SS. Patients and methods: Data for this retrospective, single-center, pilot study were based on a chart review of 48 sequential patients with recalcitrant dry eye who were evaluated for SS via serological analysis. Data presented include the presence of the autoantibodies identified through the serological biomarker analysis and identification of the concurrent dry eye treatment modalities. Results: Eleven out of 48 patients (23%) tested positive for biomarkers associated with SS. Autoantibodies for salivary protein-1, parotid secretory protein 1, and carbonic anhydrase VI, markers associated with the early development of SS, were detected in 91% (ten out of eleven) of the patients who tested positive for SS, whereas 27% (three out of eleven) of patients tested positive for the traditional SS markers, SS-A and/or SS-B. Common treatment modalities utilized in SS patients included omega-3 supplements (82%), topical cyclosporine (74%), and artificial tear solutions (64%), as compared to omega-3 supplements (80%), hot-mask therapy (77%), and artificial tear solutions (77%), in SS-negative patients. Conclusion: Evaluation for salivary protein-1, parotid secretory protein 1, and carbonic anhydrase VI biomarkers allows for identification of a subset of patients with biomarkers associated with SS that may not be identified through the traditional assessments (SS-A/SS-B). Earlier recognition of SS biomarkers allows for a confirmatory diagnosis and appropriate management of this systemic, progressive condition. Keywords: Sjögren’s syndrome, dry eye, autoantibodies, autoimmuneMatossian CMicucci JDove Medical PressarticleSjögren’s SyndromeDry EyeAutoantibodiesAutoimmuneOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 1329-1334 (2016)
institution DOAJ
collection DOAJ
language EN
topic Sjögren’s Syndrome
Dry Eye
Autoantibodies
Autoimmune
Ophthalmology
RE1-994
spellingShingle Sjögren’s Syndrome
Dry Eye
Autoantibodies
Autoimmune
Ophthalmology
RE1-994
Matossian C
Micucci J
Characterization of the serological biomarkers associated with Sjögren’s syndrome in patients with recalcitrant dry eye disease
description Cynthia Matossian,1,2 Joan Micucci1 1Matossian Eye Associates, Doylestown, PA, USA; 2Department of Ophthalmology, Temple University School of Medicine, Philadelphia, PA, USA Purpose: The purpose was to characterize the biomarkers associated with Sjögren’s syndrome (SS) identified in the serological samples of patients with recalcitrant dry eye disease; additionally, the modalities utilized in the treatment of dry eye disease were evaluated for subsets of patients with and without SS. Patients and methods: Data for this retrospective, single-center, pilot study were based on a chart review of 48 sequential patients with recalcitrant dry eye who were evaluated for SS via serological analysis. Data presented include the presence of the autoantibodies identified through the serological biomarker analysis and identification of the concurrent dry eye treatment modalities. Results: Eleven out of 48 patients (23%) tested positive for biomarkers associated with SS. Autoantibodies for salivary protein-1, parotid secretory protein 1, and carbonic anhydrase VI, markers associated with the early development of SS, were detected in 91% (ten out of eleven) of the patients who tested positive for SS, whereas 27% (three out of eleven) of patients tested positive for the traditional SS markers, SS-A and/or SS-B. Common treatment modalities utilized in SS patients included omega-3 supplements (82%), topical cyclosporine (74%), and artificial tear solutions (64%), as compared to omega-3 supplements (80%), hot-mask therapy (77%), and artificial tear solutions (77%), in SS-negative patients. Conclusion: Evaluation for salivary protein-1, parotid secretory protein 1, and carbonic anhydrase VI biomarkers allows for identification of a subset of patients with biomarkers associated with SS that may not be identified through the traditional assessments (SS-A/SS-B). Earlier recognition of SS biomarkers allows for a confirmatory diagnosis and appropriate management of this systemic, progressive condition. Keywords: Sjögren’s syndrome, dry eye, autoantibodies, autoimmune
format article
author Matossian C
Micucci J
author_facet Matossian C
Micucci J
author_sort Matossian C
title Characterization of the serological biomarkers associated with Sjögren’s syndrome in patients with recalcitrant dry eye disease
title_short Characterization of the serological biomarkers associated with Sjögren’s syndrome in patients with recalcitrant dry eye disease
title_full Characterization of the serological biomarkers associated with Sjögren’s syndrome in patients with recalcitrant dry eye disease
title_fullStr Characterization of the serological biomarkers associated with Sjögren’s syndrome in patients with recalcitrant dry eye disease
title_full_unstemmed Characterization of the serological biomarkers associated with Sjögren’s syndrome in patients with recalcitrant dry eye disease
title_sort characterization of the serological biomarkers associated with sjögren’s syndrome in patients with recalcitrant dry eye disease
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/24a4f65176544330a5f84602d4e79a62
work_keys_str_mv AT matossianc characterizationoftheserologicalbiomarkersassociatedwithsjoumlgrenrsquossyndromeinpatientswithrecalcitrantdryeyedisease
AT micuccij characterizationoftheserologicalbiomarkersassociatedwithsjoumlgrenrsquossyndromeinpatientswithrecalcitrantdryeyedisease
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