Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments

Abstract Genome-wide association (GWAS) and epistatic (GWES) studies along with expression studies in soybean [Glycine max (L.) Merr.] were leveraged to dissect the genetics of Sclerotinia stem rot (SSR) [caused by Sclerotinia sclerotiorum (Lib.) de Bary], a significant fungal disease causing yield...

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Autores principales:	Tara C. Moellers, Arti Singh, Jiaoping Zhang, Jae Brungardt, Mehdi Kabbage, Daren S. Mueller, Craig R. Grau, Ashish Ranjan, Damon L. Smith, R. V. Chowda-Reddy, Asheesh K. Singh
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Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24adc21b43ae44879012092968dd3167
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spelling	oai:doaj.org-article:24adc21b43ae44879012092968dd31672021-12-02T16:07:01ZMain and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments10.1038/s41598-017-03695-92045-2322https://doaj.org/article/24adc21b43ae44879012092968dd31672017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03695-9https://doaj.org/toc/2045-2322Abstract Genome-wide association (GWAS) and epistatic (GWES) studies along with expression studies in soybean [Glycine max (L.) Merr.] were leveraged to dissect the genetics of Sclerotinia stem rot (SSR) [caused by Sclerotinia sclerotiorum (Lib.) de Bary], a significant fungal disease causing yield and quality losses. A large association panel of 466 diverse plant introduction accessions were phenotyped in multiple field and controlled environments to: (1) discover sources of resistance, (2) identify SNPs associated with resistance, and (3) determine putative candidate genes to elucidate the mode of resistance. We report 58 significant main effect loci and 24 significant epistatic interactions associated with SSR resistance, with candidate genes involved in a wide range of processes including cell wall structure, hormone signaling, and sugar allocation related to plant immunity, revealing the complex nature of SSR resistance. Putative candidate genes [for example, PHYTOALEXIN DEFFICIENT 4 (PAD4), ETHYLENE-INSENSITIVE 3-LIKE 1 (EIL3), and ETHYLENE RESPONSE FACTOR 1 (ERF1)] clustered into salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) pathways suggest the involvement of a complex hormonal network typically activated by both necrotrophic (ET/JA) and biotrophic (SA) pathogens supporting that S. sclerotiorum is a hemibiotrophic plant pathogen.Tara C. MoellersArti SinghJiaoping ZhangJae BrungardtMehdi KabbageDaren S. MuellerCraig R. GrauAshish RanjanDamon L. SmithR. V. Chowda-ReddyAsheesh K. SinghNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tara C. Moellers Arti Singh Jiaoping Zhang Jae Brungardt Mehdi Kabbage Daren S. Mueller Craig R. Grau Ashish Ranjan Damon L. Smith R. V. Chowda-Reddy Asheesh K. Singh Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments
description	Abstract Genome-wide association (GWAS) and epistatic (GWES) studies along with expression studies in soybean [Glycine max (L.) Merr.] were leveraged to dissect the genetics of Sclerotinia stem rot (SSR) [caused by Sclerotinia sclerotiorum (Lib.) de Bary], a significant fungal disease causing yield and quality losses. A large association panel of 466 diverse plant introduction accessions were phenotyped in multiple field and controlled environments to: (1) discover sources of resistance, (2) identify SNPs associated with resistance, and (3) determine putative candidate genes to elucidate the mode of resistance. We report 58 significant main effect loci and 24 significant epistatic interactions associated with SSR resistance, with candidate genes involved in a wide range of processes including cell wall structure, hormone signaling, and sugar allocation related to plant immunity, revealing the complex nature of SSR resistance. Putative candidate genes [for example, PHYTOALEXIN DEFFICIENT 4 (PAD4), ETHYLENE-INSENSITIVE 3-LIKE 1 (EIL3), and ETHYLENE RESPONSE FACTOR 1 (ERF1)] clustered into salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) pathways suggest the involvement of a complex hormonal network typically activated by both necrotrophic (ET/JA) and biotrophic (SA) pathogens supporting that S. sclerotiorum is a hemibiotrophic plant pathogen.
format	article
author	Tara C. Moellers Arti Singh Jiaoping Zhang Jae Brungardt Mehdi Kabbage Daren S. Mueller Craig R. Grau Ashish Ranjan Damon L. Smith R. V. Chowda-Reddy Asheesh K. Singh
author_facet	Tara C. Moellers Arti Singh Jiaoping Zhang Jae Brungardt Mehdi Kabbage Daren S. Mueller Craig R. Grau Ashish Ranjan Damon L. Smith R. V. Chowda-Reddy Asheesh K. Singh
author_sort	Tara C. Moellers
title	Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments
title_short	Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments
title_full	Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments
title_fullStr	Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments
title_full_unstemmed	Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments
title_sort	main and epistatic loci studies in soybean for sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/24adc21b43ae44879012092968dd3167
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Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments

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