Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells

Epidermal cultures can treat skin diseases, such as Junctional Epidermolysis Bullosa, but the signature of stem cells is unclear. By single cell RNAseq analyses on human keratinocytes, the authors identify the molecular profile of holoclones and the role of FOXM1 in regulating the proliferative pote...

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Autores principales:	Elena Enzo, Alessia Secone Seconetti, Mattia Forcato, Elena Tenedini, Maria Pia Polito, Irene Sala, Sonia Carulli, Roberta Contin, Clelia Peano, Enrico Tagliafico, Silvio Bicciato, Sergio Bondanza, Michele De Luca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/24ade267e8ad41b39a4b9790df32c377
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spelling	oai:doaj.org-article:24ade267e8ad41b39a4b9790df32c3772021-12-02T16:49:11ZSingle-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells10.1038/s41467-021-22779-92041-1723https://doaj.org/article/24ade267e8ad41b39a4b9790df32c3772021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22779-9https://doaj.org/toc/2041-1723Epidermal cultures can treat skin diseases, such as Junctional Epidermolysis Bullosa, but the signature of stem cells is unclear. By single cell RNAseq analyses on human keratinocytes, the authors identify the molecular profile of holoclones and the role of FOXM1 in regulating the proliferative potential of epidermal stem cells.Elena EnzoAlessia Secone SeconettiMattia ForcatoElena TenediniMaria Pia PolitoIrene SalaSonia CarulliRoberta ContinClelia PeanoEnrico TagliaficoSilvio BicciatoSergio BondanzaMichele De LucaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elena Enzo Alessia Secone Seconetti Mattia Forcato Elena Tenedini Maria Pia Polito Irene Sala Sonia Carulli Roberta Contin Clelia Peano Enrico Tagliafico Silvio Bicciato Sergio Bondanza Michele De Luca Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells
description	Epidermal cultures can treat skin diseases, such as Junctional Epidermolysis Bullosa, but the signature of stem cells is unclear. By single cell RNAseq analyses on human keratinocytes, the authors identify the molecular profile of holoclones and the role of FOXM1 in regulating the proliferative potential of epidermal stem cells.
format	article
author	Elena Enzo Alessia Secone Seconetti Mattia Forcato Elena Tenedini Maria Pia Polito Irene Sala Sonia Carulli Roberta Contin Clelia Peano Enrico Tagliafico Silvio Bicciato Sergio Bondanza Michele De Luca
author_facet	Elena Enzo Alessia Secone Seconetti Mattia Forcato Elena Tenedini Maria Pia Polito Irene Sala Sonia Carulli Roberta Contin Clelia Peano Enrico Tagliafico Silvio Bicciato Sergio Bondanza Michele De Luca
author_sort	Elena Enzo
title	Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells
title_short	Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells
title_full	Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells
title_fullStr	Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells
title_full_unstemmed	Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells
title_sort	single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by foxm1 in human epidermal stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/24ade267e8ad41b39a4b9790df32c377
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Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells

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