Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation

Potassium ion concentrations, controlled by ion pumps and potassium channels, predominantly govern a cell′s membrane potential and the tone in the vessels. Calcium-activated potassium channels respond to two different stimuli-changes in voltage and/or changes in intracellular free calcium. Large con...

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Autores principales:	Divya Guntur, Horst Olschewski, Péter Enyedi, Réka Csáki, Andrea Olschewski, Chandran Nagaraj
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	large conductance calcium-activated potassium (BKCa) channels KCNMA1 KCNMB1 KCNMB2 LRRC26 pulmonary circulation Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/24b76b3506734b778fc1601f27624dd6
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spelling	oai:doaj.org-article:24b76b3506734b778fc1601f27624dd62021-11-25T16:52:59ZRevisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation10.3390/biom111116292218-273Xhttps://doaj.org/article/24b76b3506734b778fc1601f27624dd62021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1629https://doaj.org/toc/2218-273XPotassium ion concentrations, controlled by ion pumps and potassium channels, predominantly govern a cell′s membrane potential and the tone in the vessels. Calcium-activated potassium channels respond to two different stimuli-changes in voltage and/or changes in intracellular free calcium. Large conductance calcium-activated potassium (BKCa) channels assemble from pore forming and various modulatory and auxiliary subunits. They are of vital significance due to their very high unitary conductance and hence their ability to rapidly cause extreme changes in the membrane potential. The pathophysiology of lung diseases in general and pulmonary hypertension, in particular, show the implication of either decreased expression and partial inactivation of BKCa channel and its subunits or mutations in the genes encoding different subunits of the channel. Signaling molecules, circulating humoral molecules, vasorelaxant agents, etc., have an influence on the open probability of the channel in pulmonary arterial vascular cells. BKCa channel is a possible therapeutic target, aimed to cause vasodilation in constricted or chronically stiffened vessels, as shown in various animal models. This review is a comprehensive collation of studies on BKCa channels in the pulmonary circulation under hypoxia (hypoxic pulmonary vasoconstriction; HPV), lung pathology, and fetal to neonatal transition, emphasising pharmacological interventions as viable therapeutic options.Divya GunturHorst OlschewskiPéter EnyediRéka CsákiAndrea OlschewskiChandran NagarajMDPI AGarticlelarge conductance calcium-activated potassium (BKCa) channelsKCNMA1KCNMB1KCNMB2LRRC26pulmonary circulationMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1629, p 1629 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	large conductance calcium-activated potassium (BKCa) channels KCNMA1 KCNMB1 KCNMB2 LRRC26 pulmonary circulation Microbiology QR1-502
spellingShingle	large conductance calcium-activated potassium (BKCa) channels KCNMA1 KCNMB1 KCNMB2 LRRC26 pulmonary circulation Microbiology QR1-502 Divya Guntur Horst Olschewski Péter Enyedi Réka Csáki Andrea Olschewski Chandran Nagaraj Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation
description	Potassium ion concentrations, controlled by ion pumps and potassium channels, predominantly govern a cell′s membrane potential and the tone in the vessels. Calcium-activated potassium channels respond to two different stimuli-changes in voltage and/or changes in intracellular free calcium. Large conductance calcium-activated potassium (BKCa) channels assemble from pore forming and various modulatory and auxiliary subunits. They are of vital significance due to their very high unitary conductance and hence their ability to rapidly cause extreme changes in the membrane potential. The pathophysiology of lung diseases in general and pulmonary hypertension, in particular, show the implication of either decreased expression and partial inactivation of BKCa channel and its subunits or mutations in the genes encoding different subunits of the channel. Signaling molecules, circulating humoral molecules, vasorelaxant agents, etc., have an influence on the open probability of the channel in pulmonary arterial vascular cells. BKCa channel is a possible therapeutic target, aimed to cause vasodilation in constricted or chronically stiffened vessels, as shown in various animal models. This review is a comprehensive collation of studies on BKCa channels in the pulmonary circulation under hypoxia (hypoxic pulmonary vasoconstriction; HPV), lung pathology, and fetal to neonatal transition, emphasising pharmacological interventions as viable therapeutic options.
format	article
author	Divya Guntur Horst Olschewski Péter Enyedi Réka Csáki Andrea Olschewski Chandran Nagaraj
author_facet	Divya Guntur Horst Olschewski Péter Enyedi Réka Csáki Andrea Olschewski Chandran Nagaraj
author_sort	Divya Guntur
title	Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation
title_short	Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation
title_full	Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation
title_fullStr	Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation
title_full_unstemmed	Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation
title_sort	revisiting the large-conductance calcium-activated potassium (bkca) channels in the pulmonary circulation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/24b76b3506734b778fc1601f27624dd6
work_keys_str_mv	AT divyaguntur revisitingthelargeconductancecalciumactivatedpotassiumbkcachannelsinthepulmonarycirculation AT horstolschewski revisitingthelargeconductancecalciumactivatedpotassiumbkcachannelsinthepulmonarycirculation AT peterenyedi revisitingthelargeconductancecalciumactivatedpotassiumbkcachannelsinthepulmonarycirculation AT rekacsaki revisitingthelargeconductancecalciumactivatedpotassiumbkcachannelsinthepulmonarycirculation AT andreaolschewski revisitingthelargeconductancecalciumactivatedpotassiumbkcachannelsinthepulmonarycirculation AT chandrannagaraj revisitingthelargeconductancecalciumactivatedpotassiumbkcachannelsinthepulmonarycirculation
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Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation

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