Ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)

Ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)

Krishnaraj Mahendraraj,1 Sneha Shrestha,1 Christine SM Lau,1,2 Ronald S Chamberlain1–4 1Department of Surgery, Saint Barnabas Medical Center, Livingston, NJ, USA; 2Saint George’s University School of Medicine, Grenada, West Indies; 3Department of Surgery, Banner MD Anderson Canc...

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Autores principales: Mahendraraj K, Shrestha S, Lau CSM, Chamberlain RS
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Ocular melanoma
Uveal melanoma
Conjunctival melanoma
SEER
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/24b86edda74643ac87049b26d7fc071a
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spelling oai:doaj.org-article:24b86edda74643ac87049b26d7fc071a2021-12-02T02:35:58ZOcular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)1177-5483https://doaj.org/article/24b86edda74643ac87049b26d7fc071a2017-01-01T00:00:00Zhttps://www.dovepress.com/ocular-melanoma-when-you-have-seen-one-you-have-not-seen-them-all-a-cl-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Krishnaraj Mahendraraj,1 Sneha Shrestha,1 Christine SM Lau,1,2 Ronald S Chamberlain1–4 1Department of Surgery, Saint Barnabas Medical Center, Livingston, NJ, USA; 2Saint George’s University School of Medicine, Grenada, West Indies; 3Department of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ, USA; 4Department of Surgery, Rutgers University, New Jersey Medical School, Newark, NJ, USA Background: Ocular melanoma (OM) comprises <5% of all melanomas. Uveal melanoma (UM) is the most common subtype of OM, while conjunctival melanoma (CM) is rare and differs significantly from UM. The purpose of this study is to evaluate a large cohort of OM patients to differentiate demographic, pathologic, and clinical factors between these two neoplasms, which may affect treatment and outcomes. Methods: The Surveillance, Epidemiology, and End Results database (1973–2012) was used to extract demographic and clinical data on 8,165 OM patients (92.1% UM and 7.9% CM). Results: Both CM and UM were most prevalent among Caucasian males in the seventh decade of life. UM patients presented more often with localized disease (90.9% vs 81.2, P<0.01). Surgery (42.8%), radiation (43.0%), or combined surgery and radiation (7.0%) were used in the treatment of UM, while CM was treated almost exclusively with surgery (88.7%). Mean overall survival was longer (15.4 vs 14.6 years; P<0.01) and mortality rates were lower in patients (38.8% vs 46.1%; P<0.01) with CM. Conclusion: Despite presenting with more advanced disease than UM, CM is associated with an increased overall survival. Surgery is the primary therapy for CM, whereas radiotherapy is the primary therapy for UM and is associated with prolonged survival. Keywords: ocular melanoma, uveal melanoma, conjunctival melanoma, SEERMahendraraj KShrestha SLau CSMChamberlain RSDove Medical PressarticleOcular melanomaUveal melanomaConjunctival melanomaSEEROphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 153-160 (2017)
institution DOAJ
collection DOAJ
language EN
topic Ocular melanoma
Uveal melanoma
Conjunctival melanoma
SEER
Ophthalmology
RE1-994
spellingShingle Ocular melanoma
Uveal melanoma
Conjunctival melanoma
SEER
Ophthalmology
RE1-994
Mahendraraj K
Shrestha S
Lau CSM
Chamberlain RS
Ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)
description Krishnaraj Mahendraraj,1 Sneha Shrestha,1 Christine SM Lau,1,2 Ronald S Chamberlain1–4 1Department of Surgery, Saint Barnabas Medical Center, Livingston, NJ, USA; 2Saint George’s University School of Medicine, Grenada, West Indies; 3Department of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ, USA; 4Department of Surgery, Rutgers University, New Jersey Medical School, Newark, NJ, USA Background: Ocular melanoma (OM) comprises <5% of all melanomas. Uveal melanoma (UM) is the most common subtype of OM, while conjunctival melanoma (CM) is rare and differs significantly from UM. The purpose of this study is to evaluate a large cohort of OM patients to differentiate demographic, pathologic, and clinical factors between these two neoplasms, which may affect treatment and outcomes. Methods: The Surveillance, Epidemiology, and End Results database (1973–2012) was used to extract demographic and clinical data on 8,165 OM patients (92.1% UM and 7.9% CM). Results: Both CM and UM were most prevalent among Caucasian males in the seventh decade of life. UM patients presented more often with localized disease (90.9% vs 81.2, P<0.01). Surgery (42.8%), radiation (43.0%), or combined surgery and radiation (7.0%) were used in the treatment of UM, while CM was treated almost exclusively with surgery (88.7%). Mean overall survival was longer (15.4 vs 14.6 years; P<0.01) and mortality rates were lower in patients (38.8% vs 46.1%; P<0.01) with CM. Conclusion: Despite presenting with more advanced disease than UM, CM is associated with an increased overall survival. Surgery is the primary therapy for CM, whereas radiotherapy is the primary therapy for UM and is associated with prolonged survival. Keywords: ocular melanoma, uveal melanoma, conjunctival melanoma, SEER
format article
author Mahendraraj K
Shrestha S
Lau CSM
Chamberlain RS
author_facet Mahendraraj K
Shrestha S
Lau CSM
Chamberlain RS
author_sort Mahendraraj K
title Ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)
title_short Ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)
title_full Ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)
title_fullStr Ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)
title_full_unstemmed Ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973–2012)
title_sort ocular melanoma-when you have seen one, you have not seen them all: a clinical outcome study from the surveillance, epidemiology and end results (seer) database (1973–2012)
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/24b86edda74643ac87049b26d7fc071a
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AT laucsm ocularmelanomawhenyouhaveseenoneyouhavenotseenthemallaclinicaloutcomestudyfromthesurveillanceepidemiologyandendresultsseerdatabase1973ndash2012
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