Long noncoding RNAs and Alzheimer's disease
Qiong Luo,1,2 Yinghui Chen1,2 1Department of Neurology, Jinshan Hospital, 2Department of Neurology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Abstract: Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. l...
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Dove Medical Press
2016
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oai:doaj.org-article:24b954630eee41cc98bf88287c58e8282021-12-02T00:34:17ZLong noncoding RNAs and Alzheimer's disease1178-1998https://doaj.org/article/24b954630eee41cc98bf88287c58e8282016-06-01T00:00:00Zhttps://www.dovepress.com/long-noncoding-rnas-and-alzheimer39s-disease-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Qiong Luo,1,2 Yinghui Chen1,2 1Department of Neurology, Jinshan Hospital, 2Department of Neurology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Abstract: Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and posttranscriptional levels. Recent studies have shown that lncRNAs are involved in many neurological diseases such as epilepsy, neurodegenerative conditions, and genetic disorders. Alzheimer’s disease is a neurodegenerative disease, which accounts for >80% of dementia in elderly subjects. In this review, we will highlight recent studies investigating the role of lncRNAs in Alzheimer’s disease and focus on some specific lncRNAs that may underlie Alzheimer’s disease pathophysiology and therefore could be potential therapeutic targets. Keywords: lncRNA, Alzheimer’s disease, ncRNAs, amyloid β peptide, BACE1, BC200, BACE1-ASLuo QChen YDove Medical PressarticlelncRNAAlzheimer’s diseasencRNAsAmyloid β peptide，β-site amyloid precursor protein cleaving enzyme-1GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 867-872 (2016) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
lncRNA Alzheimer’s disease ncRNAs Amyloid β peptide，β-site amyloid precursor protein cleaving enzyme-1 Geriatrics RC952-954.6 |
| spellingShingle |
lncRNA Alzheimer’s disease ncRNAs Amyloid β peptide，β-site amyloid precursor protein cleaving enzyme-1 Geriatrics RC952-954.6 Luo Q Chen Y Long noncoding RNAs and Alzheimer's disease |
| description |
Qiong Luo,1,2 Yinghui Chen1,2 1Department of Neurology, Jinshan Hospital, 2Department of Neurology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Abstract: Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and posttranscriptional levels. Recent studies have shown that lncRNAs are involved in many neurological diseases such as epilepsy, neurodegenerative conditions, and genetic disorders. Alzheimer’s disease is a neurodegenerative disease, which accounts for >80% of dementia in elderly subjects. In this review, we will highlight recent studies investigating the role of lncRNAs in Alzheimer’s disease and focus on some specific lncRNAs that may underlie Alzheimer’s disease pathophysiology and therefore could be potential therapeutic targets. Keywords: lncRNA, Alzheimer’s disease, ncRNAs, amyloid β peptide, BACE1, BC200, BACE1-AS |
| format |
article |
| author |
Luo Q Chen Y |
| author_facet |
Luo Q Chen Y |
| author_sort |
Luo Q |
| title |
Long noncoding RNAs and Alzheimer's disease |
| title_short |
Long noncoding RNAs and Alzheimer's disease |
| title_full |
Long noncoding RNAs and Alzheimer's disease |
| title_fullStr |
Long noncoding RNAs and Alzheimer's disease |
| title_full_unstemmed |
Long noncoding RNAs and Alzheimer's disease |
| title_sort |
long noncoding rnas and alzheimer's disease |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/24b954630eee41cc98bf88287c58e828 |
| work_keys_str_mv |
AT luoq longnoncodingrnasandalzheimer39sdisease AT cheny longnoncodingrnasandalzheimer39sdisease |
| _version_ |
1718403603676266496 |