Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer

Abstract Background Although skeletal muscle index (SMI) and radiodensity (SMD) are well‐known prognostic factors, the clinical impact of the integrated measure, known as skeletal muscle gauge (SMG), has been limited in patients with colorectal cancer (CRC). Patients and Methods A total of 727 and 2...

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Autores principales:	In Kyu Park, Song Soo Yang, Eric Chung, Eun‐Suk Cho, Hye Sun Lee, Su‐Jin Shin, Yeong Cheol Im, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	colorectal cancer myosteatosis sarcopenia skeletal muscle gauge skeletal muscle index skeletal muscle radiodensity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/24b9f178e26f4fe0a0e8382ed6e21ec5
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spelling	oai:doaj.org-article:24b9f178e26f4fe0a0e8382ed6e21ec52021-12-01T04:49:15ZSkeletal muscle gauge as a prognostic factor in patients with colorectal cancer2045-763410.1002/cam4.4354https://doaj.org/article/24b9f178e26f4fe0a0e8382ed6e21ec52021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4354https://doaj.org/toc/2045-7634Abstract Background Although skeletal muscle index (SMI) and radiodensity (SMD) are well‐known prognostic factors, the clinical impact of the integrated measure, known as skeletal muscle gauge (SMG), has been limited in patients with colorectal cancer (CRC). Patients and Methods A total of 727 and 268 patients with CRC at two tertiary centers were included and allocated into the training and test sets, respectively. Preoperative slice computed tomography images of the third lumbar area were evaluated for SMI and SMD. SMG was calculated as SMI × SMD and expressed as an arbitrary unit (AU). The optimal cutoff SMG value was determined to maximize the overall survival (OS) difference between the groups with respect to sex in the training set. The multivariate Cox proportional hazard model evaluated the association of its clinical significance. Results With regard to SMG, 1640 and 1523 AU were identified as cutoff values for males and females, respectively. The patients with low SMG values showed significantly worse 5‐year OS than those with high SMG values in the two datasets (both p < 0.001). In the multivariate analysis, low SMG was identified as an independent poor prognostic factor of OS in the training set (hazard ratio 2.18, 95% confidence interval 1.43–3.32, p < 0.001) and test set (hazard ratio 1.79, 95% confidence interval 1.07–3.00, p = 0.025), whereas SMI and SMD were not. Conclusion SMG acts synergistically to improve its prognostic predictive accuracy as compared with SMI or SMD alone in patients with CRC. Additional research is warranted to define its significance in different ethnic groups.In Kyu ParkSong Soo YangEric ChungEun‐Suk ChoHye Sun LeeSu‐Jin ShinYeong Cheol ImEun Jung ParkSeung Hyuk BaikKang Young LeeJeonghyun KangWileyarticlecolorectal cancermyosteatosissarcopeniaskeletal muscle gaugeskeletal muscle indexskeletal muscle radiodensityNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8451-8461 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer myosteatosis sarcopenia skeletal muscle gauge skeletal muscle index skeletal muscle radiodensity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	colorectal cancer myosteatosis sarcopenia skeletal muscle gauge skeletal muscle index skeletal muscle radiodensity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 In Kyu Park Song Soo Yang Eric Chung Eun‐Suk Cho Hye Sun Lee Su‐Jin Shin Yeong Cheol Im Eun Jung Park Seung Hyuk Baik Kang Young Lee Jeonghyun Kang Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer
description	Abstract Background Although skeletal muscle index (SMI) and radiodensity (SMD) are well‐known prognostic factors, the clinical impact of the integrated measure, known as skeletal muscle gauge (SMG), has been limited in patients with colorectal cancer (CRC). Patients and Methods A total of 727 and 268 patients with CRC at two tertiary centers were included and allocated into the training and test sets, respectively. Preoperative slice computed tomography images of the third lumbar area were evaluated for SMI and SMD. SMG was calculated as SMI × SMD and expressed as an arbitrary unit (AU). The optimal cutoff SMG value was determined to maximize the overall survival (OS) difference between the groups with respect to sex in the training set. The multivariate Cox proportional hazard model evaluated the association of its clinical significance. Results With regard to SMG, 1640 and 1523 AU were identified as cutoff values for males and females, respectively. The patients with low SMG values showed significantly worse 5‐year OS than those with high SMG values in the two datasets (both p < 0.001). In the multivariate analysis, low SMG was identified as an independent poor prognostic factor of OS in the training set (hazard ratio 2.18, 95% confidence interval 1.43–3.32, p < 0.001) and test set (hazard ratio 1.79, 95% confidence interval 1.07–3.00, p = 0.025), whereas SMI and SMD were not. Conclusion SMG acts synergistically to improve its prognostic predictive accuracy as compared with SMI or SMD alone in patients with CRC. Additional research is warranted to define its significance in different ethnic groups.
format	article
author	In Kyu Park Song Soo Yang Eric Chung Eun‐Suk Cho Hye Sun Lee Su‐Jin Shin Yeong Cheol Im Eun Jung Park Seung Hyuk Baik Kang Young Lee Jeonghyun Kang
author_facet	In Kyu Park Song Soo Yang Eric Chung Eun‐Suk Cho Hye Sun Lee Su‐Jin Shin Yeong Cheol Im Eun Jung Park Seung Hyuk Baik Kang Young Lee Jeonghyun Kang
author_sort	In Kyu Park
title	Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer
title_short	Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer
title_full	Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer
title_fullStr	Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer
title_full_unstemmed	Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer
title_sort	skeletal muscle gauge as a prognostic factor in patients with colorectal cancer
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/24b9f178e26f4fe0a0e8382ed6e21ec5
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Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer

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