Helicobacter pylori infection and eradication outcomes among Vietnamese patients in the same households: Findings from a non-randomized study.

<h4>Objective</h4>Familial transmission can possibly influence the infection and treatment of Helicobacter pylori. This study aimed to describe the prevalence of H. pylori infection and outcomes of eradication treatment among Vietnamese patients who live in the same households.<h4>...

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Autores principales:	Long Van Dao, Hang Viet Dao, Hao Thi Nguyen, Vung Thi Vu, Anh Thi Ngoc Tran, Vu Quoc Dat, Long Bao Hoang, Hong Thi Van Nguyen, Thang Duy Nguyen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24bb1fc38c034ca1ac06e03220be0649
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spelling	oai:doaj.org-article:24bb1fc38c034ca1ac06e03220be06492021-12-02T20:16:09ZHelicobacter pylori infection and eradication outcomes among Vietnamese patients in the same households: Findings from a non-randomized study.1932-620310.1371/journal.pone.0260454https://doaj.org/article/24bb1fc38c034ca1ac06e03220be06492021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260454https://doaj.org/toc/1932-6203<h4>Objective</h4>Familial transmission can possibly influence the infection and treatment of Helicobacter pylori. This study aimed to describe the prevalence of H. pylori infection and outcomes of eradication treatment among Vietnamese patients who live in the same households.<h4>Methods</h4>We conducted a prospective cohort study of Vietnamese household members with upper gastrointestinal complaints. Participants received esophagogastroduodenoscopy and H. pylori testing. The H. pylori-positive patients were treated and asked to return for follow-up within 4 months. To explore factors associated with H. pylori infection at baseline, we performed multilevel logistic regression to account for the clustering effect of living in the same households. To explore factors associated with eradication failure, we used Poisson regression with robust variance estimation to estimate the risk ratio.<h4>Results</h4>The prevalence of H. pylori infection was 83.5% and highest among children <12 years old (92.2%) in 1,272 patients from 482 households. There were variations in H. pylori infection across households (intraclass correlation = 0.14, 95% confidence interval (CI) 0.05, 0.33). Children aged <12 years had higher odds of H. pylori infection (odds ratio = 3.41, 95%CI 2.11, 5.50). At follow-up, H. pylori was eradicated in 264 of 341 patients (77.4%). The risk of eradication failure was lower for the sequential regimen with tetracycline.<h4>Conclusion</h4>H. pylori infection was common among people living in the same households. Eradication success for H. pylori was higher for the tetracycline sequential regimen. More research should be focused on how family factors influence H. pylori infection and on eradication treatment.Long Van DaoHang Viet DaoHao Thi NguyenVung Thi VuAnh Thi Ngoc TranVu Quoc DatLong Bao HoangHong Thi Van NguyenThang Duy NguyenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260454 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Long Van Dao Hang Viet Dao Hao Thi Nguyen Vung Thi Vu Anh Thi Ngoc Tran Vu Quoc Dat Long Bao Hoang Hong Thi Van Nguyen Thang Duy Nguyen Helicobacter pylori infection and eradication outcomes among Vietnamese patients in the same households: Findings from a non-randomized study.
description	<h4>Objective</h4>Familial transmission can possibly influence the infection and treatment of Helicobacter pylori. This study aimed to describe the prevalence of H. pylori infection and outcomes of eradication treatment among Vietnamese patients who live in the same households.<h4>Methods</h4>We conducted a prospective cohort study of Vietnamese household members with upper gastrointestinal complaints. Participants received esophagogastroduodenoscopy and H. pylori testing. The H. pylori-positive patients were treated and asked to return for follow-up within 4 months. To explore factors associated with H. pylori infection at baseline, we performed multilevel logistic regression to account for the clustering effect of living in the same households. To explore factors associated with eradication failure, we used Poisson regression with robust variance estimation to estimate the risk ratio.<h4>Results</h4>The prevalence of H. pylori infection was 83.5% and highest among children <12 years old (92.2%) in 1,272 patients from 482 households. There were variations in H. pylori infection across households (intraclass correlation = 0.14, 95% confidence interval (CI) 0.05, 0.33). Children aged <12 years had higher odds of H. pylori infection (odds ratio = 3.41, 95%CI 2.11, 5.50). At follow-up, H. pylori was eradicated in 264 of 341 patients (77.4%). The risk of eradication failure was lower for the sequential regimen with tetracycline.<h4>Conclusion</h4>H. pylori infection was common among people living in the same households. Eradication success for H. pylori was higher for the tetracycline sequential regimen. More research should be focused on how family factors influence H. pylori infection and on eradication treatment.
format	article
author	Long Van Dao Hang Viet Dao Hao Thi Nguyen Vung Thi Vu Anh Thi Ngoc Tran Vu Quoc Dat Long Bao Hoang Hong Thi Van Nguyen Thang Duy Nguyen
author_facet	Long Van Dao Hang Viet Dao Hao Thi Nguyen Vung Thi Vu Anh Thi Ngoc Tran Vu Quoc Dat Long Bao Hoang Hong Thi Van Nguyen Thang Duy Nguyen
author_sort	Long Van Dao
title	Helicobacter pylori infection and eradication outcomes among Vietnamese patients in the same households: Findings from a non-randomized study.
title_short	Helicobacter pylori infection and eradication outcomes among Vietnamese patients in the same households: Findings from a non-randomized study.
title_full	Helicobacter pylori infection and eradication outcomes among Vietnamese patients in the same households: Findings from a non-randomized study.
title_fullStr	Helicobacter pylori infection and eradication outcomes among Vietnamese patients in the same households: Findings from a non-randomized study.
title_full_unstemmed	Helicobacter pylori infection and eradication outcomes among Vietnamese patients in the same households: Findings from a non-randomized study.
title_sort	helicobacter pylori infection and eradication outcomes among vietnamese patients in the same households: findings from a non-randomized study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/24bb1fc38c034ca1ac06e03220be0649
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Helicobacter pylori infection and eradication outcomes among Vietnamese patients in the same households: Findings from a non-randomized study.

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