EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS

Abstract. Complicated systemic inflammatory response syndrome in patients undergone open-heart surgery is an important issue of cardiac surgery. The conditions and trigger mechanisms leading to such a complication remain unclear.We studied the impact of mechanincal myocardial injury products release...

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Autores principales:	V. G. Matveeva, A. S. Golovkin, M. N. Chernova, I. V. Kudryavtsev, S. V. Ivanov, E. V. Grigoriev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	monocytes cellular damage cytokines inflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/24bd445e361b4c88ac3a9aef332a3724
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spelling	oai:doaj.org-article:24bd445e361b4c88ac3a9aef332a37242021-11-18T08:03:43ZEFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS1563-06252313-741X10.15789/1563-0625-2013-5-439-448https://doaj.org/article/24bd445e361b4c88ac3a9aef332a37242014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/660https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Complicated systemic inflammatory response syndrome in patients undergone open-heart surgery is an important issue of cardiac surgery. The conditions and trigger mechanisms leading to such a complication remain unclear.We studied the impact of mechanincal myocardial injury products released into blood during open-heart surgery, lipopolysaccharides and their combination on isolated monocytes.It was found that mechanically injured myocardial tissue can be a source of intracellular heat shock protein 70 (Hsp70). The content of Hsp70 in the cytosolic cardiomyocyte fraction responsible for mechanical myocardial injury modeling corresponds to the level of proinflammatory cytokine production by monocytes and the density of TLR4 surface expression. The study results confirm the synergy and potentiation of the combined impact of mechanical myocardial injury products and lipopolysaccharides on the levels of cytokine production by monocytes.V. G. MatveevaA. S. GolovkinM. N. ChernovaI. V. KudryavtsevS. V. IvanovE. V. GrigorievSPb RAACIarticlemonocytescellular damagecytokinesinflammationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 5, Pp 439-448 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	monocytes cellular damage cytokines inflammation Immunologic diseases. Allergy RC581-607
spellingShingle	monocytes cellular damage cytokines inflammation Immunologic diseases. Allergy RC581-607 V. G. Matveeva A. S. Golovkin M. N. Chernova I. V. Kudryavtsev S. V. Ivanov E. V. Grigoriev EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS
description	Abstract. Complicated systemic inflammatory response syndrome in patients undergone open-heart surgery is an important issue of cardiac surgery. The conditions and trigger mechanisms leading to such a complication remain unclear.We studied the impact of mechanincal myocardial injury products released into blood during open-heart surgery, lipopolysaccharides and their combination on isolated monocytes.It was found that mechanically injured myocardial tissue can be a source of intracellular heat shock protein 70 (Hsp70). The content of Hsp70 in the cytosolic cardiomyocyte fraction responsible for mechanical myocardial injury modeling corresponds to the level of proinflammatory cytokine production by monocytes and the density of TLR4 surface expression. The study results confirm the synergy and potentiation of the combined impact of mechanical myocardial injury products and lipopolysaccharides on the levels of cytokine production by monocytes.
format	article
author	V. G. Matveeva A. S. Golovkin M. N. Chernova I. V. Kudryavtsev S. V. Ivanov E. V. Grigoriev
author_facet	V. G. Matveeva A. S. Golovkin M. N. Chernova I. V. Kudryavtsev S. V. Ivanov E. V. Grigoriev
author_sort	V. G. Matveeva
title	EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS
title_short	EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS
title_full	EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS
title_fullStr	EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS
title_full_unstemmed	EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS
title_sort	effects of myocardial cytosolic fraction and lipopolysaccharide upon monocytic functions
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/24bd445e361b4c88ac3a9aef332a3724
work_keys_str_mv	AT vgmatveeva effectsofmyocardialcytosolicfractionandlipopolysaccharideuponmonocyticfunctions AT asgolovkin effectsofmyocardialcytosolicfractionandlipopolysaccharideuponmonocyticfunctions AT mnchernova effectsofmyocardialcytosolicfractionandlipopolysaccharideuponmonocyticfunctions AT ivkudryavtsev effectsofmyocardialcytosolicfractionandlipopolysaccharideuponmonocyticfunctions AT svivanov effectsofmyocardialcytosolicfractionandlipopolysaccharideuponmonocyticfunctions AT evgrigoriev effectsofmyocardialcytosolicfractionandlipopolysaccharideuponmonocyticfunctions
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EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS

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