An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in <named-content content-type="genus-species">Trypanosoma cruzi</named-content>

An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in <named-content content-type="genus-species">Trypanosoma cruzi</named-content>

ABSTRACT Trypanosoma cruzi, the etiologic agent of Chagas disease, undergoes drastic metabolic changes when it transits between a vector and mammalian hosts. Amino acid catabolism leads to the production of ammonium (NH4+), which needs to be detoxified. However, T. cruzi does not possess a urea cycl...

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Autores principales: Teresa Cruz-Bustos, Evgeniy Potapenko, Melissa Storey, Roberto Docampo
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
Trypanosoma cruzi
amino acids
ammonia
ammonium
autophagy
lysosomes
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/24be5d9c23dc42129117416062f59e64
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