The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles

The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles

Mohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah H Al-Mohy, Magdi Mohamed Ghannam Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Mohamed Anwar K AbdelhalimBiomedical Physics, Department of Physics and Astronomy, College of Science...

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Autores principales: Abdelhalim MAK, Qaid HAY, Al-Mohy YH, Ghannam MM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
gold nanoparticles
vitamin e
alpha-lipoic acid
nephrotoxicity
lipid peroxidation
natural antioxidants
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/24c13c72629e4d7881de56bd0959f0a5
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spelling oai:doaj.org-article:24c13c72629e4d7881de56bd0959f0a52021-12-02T11:18:39ZThe Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles1178-2013https://doaj.org/article/24c13c72629e4d7881de56bd0959f0a52020-01-01T00:00:00Zhttps://www.dovepress.com/the-protective-roles-of-vitamin-e-and-alpha-lipoic-acid-against-nephro-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah H Al-Mohy, Magdi Mohamed Ghannam Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Mohamed Anwar K AbdelhalimBiomedical Physics, Department of Physics and Astronomy, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi ArabiaTel +966509649633Email abdelhalimmak@yahoo.comBackground: Recently, use of nanotechnology in biomedical applications such as drug delivery and diagnostic and therapeutic tools has increased greatly. This study evaluated gold nanoparticle (GNPs)-induced nephrotoxic effects in rats in vivo, and examined protective effects of alpha-lipoic acid (α-Lip) and Vitamin E (Vit E) against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs.Materials and Methods: Twenty-four male Wistar-Kyoto rats (220– 240 g, 12 weeks old) were dosed with 50 μL of 10 nm GNPs administered intraperitoneally with or without 200 mg/kg/day Vit E or 200 mg/kg/day α-Lip. Serum was prepared for biochemical analyses. Kidney function was evaluated through measurement of creatinine (CR), uric acid (URIC), and blood urea nitrogen (BUN). Oxidative stress and lipid peroxidation were evaluated by measurement of reduced glutathione (GSH) and malondialdehyde (MDA) in kidney tissue homogenates.Results and Conclusions: The results showed a significant rise in serum kidney function biomarkers including urea, URIC, CR, and BUN in GNP-treated rats compared to normal control rats. Furthermore, GNPs led to decreased GSH and elevated MDA levels. Vit E or α-Lip supplementation showed a beneficial effect against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs. This study suggests that use of natural antioxidants in combination with GNPs may be a useful tool in preventing GNPs toxicity.Keywords: gold nanoparticles, Vitamin E, alpha-lipoic acid, nephrotoxicity, lipid peroxidation, natural antioxidantsAbdelhalim MAKQaid HAYAl-Mohy YHGhannam MMDove Medical Pressarticlegold nanoparticlesvitamin ealpha-lipoic acidnephrotoxicitylipid peroxidationnatural antioxidantsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 729-734 (2020)
institution DOAJ
collection DOAJ
language EN
topic gold nanoparticles
vitamin e
alpha-lipoic acid
nephrotoxicity
lipid peroxidation
natural antioxidants
Medicine (General)
R5-920
spellingShingle gold nanoparticles
vitamin e
alpha-lipoic acid
nephrotoxicity
lipid peroxidation
natural antioxidants
Medicine (General)
R5-920
Abdelhalim MAK
Qaid HAY
Al-Mohy YH
Ghannam MM
The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles
description Mohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah H Al-Mohy, Magdi Mohamed Ghannam Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Mohamed Anwar K AbdelhalimBiomedical Physics, Department of Physics and Astronomy, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi ArabiaTel +966509649633Email abdelhalimmak@yahoo.comBackground: Recently, use of nanotechnology in biomedical applications such as drug delivery and diagnostic and therapeutic tools has increased greatly. This study evaluated gold nanoparticle (GNPs)-induced nephrotoxic effects in rats in vivo, and examined protective effects of alpha-lipoic acid (α-Lip) and Vitamin E (Vit E) against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs.Materials and Methods: Twenty-four male Wistar-Kyoto rats (220– 240 g, 12 weeks old) were dosed with 50 μL of 10 nm GNPs administered intraperitoneally with or without 200 mg/kg/day Vit E or 200 mg/kg/day α-Lip. Serum was prepared for biochemical analyses. Kidney function was evaluated through measurement of creatinine (CR), uric acid (URIC), and blood urea nitrogen (BUN). Oxidative stress and lipid peroxidation were evaluated by measurement of reduced glutathione (GSH) and malondialdehyde (MDA) in kidney tissue homogenates.Results and Conclusions: The results showed a significant rise in serum kidney function biomarkers including urea, URIC, CR, and BUN in GNP-treated rats compared to normal control rats. Furthermore, GNPs led to decreased GSH and elevated MDA levels. Vit E or α-Lip supplementation showed a beneficial effect against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs. This study suggests that use of natural antioxidants in combination with GNPs may be a useful tool in preventing GNPs toxicity.Keywords: gold nanoparticles, Vitamin E, alpha-lipoic acid, nephrotoxicity, lipid peroxidation, natural antioxidants
format article
author Abdelhalim MAK
Qaid HAY
Al-Mohy YH
Ghannam MM
author_facet Abdelhalim MAK
Qaid HAY
Al-Mohy YH
Ghannam MM
author_sort Abdelhalim MAK
title The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles
title_short The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles
title_full The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles
title_fullStr The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles
title_full_unstemmed The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles
title_sort protective roles of vitamin e and α-lipoic acid against nephrotoxicity, lipid peroxidation, and inflammatory damage induced by gold nanoparticles
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/24c13c72629e4d7881de56bd0959f0a5
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