Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury

Myocardial ischemia–reperfusion injury stabilizes the hypoxia-inducible factor HIF2-alpha. Here, the authors show that HIF2-alpha protects the heart from injury via induction of the epidermal growth factor amphiregulin, and that amphiregulin administration is cardioprotective in mice.

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Autores principales:	Michael Koeppen, Jae W. Lee, Seong-Wook Seo, Kelley S. Brodsky, Simone Kreth, Ivana V. Yang, Peter M. Buttrick, Tobias Eckle, Holger K. Eltzschig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/24c74b3146bb47afaae1377656aa4429
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spelling	oai:doaj.org-article:24c74b3146bb47afaae1377656aa44292021-12-02T14:38:48ZHypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury10.1038/s41467-018-03105-22041-1723https://doaj.org/article/24c74b3146bb47afaae1377656aa44292018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03105-2https://doaj.org/toc/2041-1723Myocardial ischemia–reperfusion injury stabilizes the hypoxia-inducible factor HIF2-alpha. Here, the authors show that HIF2-alpha protects the heart from injury via induction of the epidermal growth factor amphiregulin, and that amphiregulin administration is cardioprotective in mice.Michael KoeppenJae W. LeeSeong-Wook SeoKelley S. BrodskySimone KrethIvana V. YangPeter M. ButtrickTobias EckleHolger K. EltzschigNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Koeppen Jae W. Lee Seong-Wook Seo Kelley S. Brodsky Simone Kreth Ivana V. Yang Peter M. Buttrick Tobias Eckle Holger K. Eltzschig Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
description	Myocardial ischemia–reperfusion injury stabilizes the hypoxia-inducible factor HIF2-alpha. Here, the authors show that HIF2-alpha protects the heart from injury via induction of the epidermal growth factor amphiregulin, and that amphiregulin administration is cardioprotective in mice.
format	article
author	Michael Koeppen Jae W. Lee Seong-Wook Seo Kelley S. Brodsky Simone Kreth Ivana V. Yang Peter M. Buttrick Tobias Eckle Holger K. Eltzschig
author_facet	Michael Koeppen Jae W. Lee Seong-Wook Seo Kelley S. Brodsky Simone Kreth Ivana V. Yang Peter M. Buttrick Tobias Eckle Holger K. Eltzschig
author_sort	Michael Koeppen
title	Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
title_short	Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
title_full	Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
title_fullStr	Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
title_full_unstemmed	Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
title_sort	hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/24c74b3146bb47afaae1377656aa4429
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Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury

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