Myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer

Abstract This study aims to evaluate the influence of myosteatosis on survival of patients after radical cystectomy (RC) for bladder cancer. We retrospectively identified 230 patients who underwent RC for bladder cancer at our three institutions between 2009 and 2018. Digitized free-hand outlines of...

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Autores principales:	Shimpei Yamashita, Yuya Iwahashi, Haruka Miyai, Takashi Iguchi, Hiroyuki Koike, Satoshi Nishizawa, Nagahide Matsumura, Keizo Hagino, Kazuro Kikkawa, Yasuo Kohjimoto, Isao Hara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24cb45c29d9c42cf9b481c3434545fbc
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spelling	oai:doaj.org-article:24cb45c29d9c42cf9b481c3434545fbc2021-12-02T13:34:10ZMyosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer10.1038/s41598-020-79340-92045-2322https://doaj.org/article/24cb45c29d9c42cf9b481c3434545fbc2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79340-9https://doaj.org/toc/2045-2322Abstract This study aims to evaluate the influence of myosteatosis on survival of patients after radical cystectomy (RC) for bladder cancer. We retrospectively identified 230 patients who underwent RC for bladder cancer at our three institutions between 2009 and 2018. Digitized free-hand outlines of the left and right psoas muscles were made on axial non-contrast computed tomography images at level L3. To assess myosteatosis, average total psoas density (ATPD) in Hounsfield Units (HU) was also calculated as an average of bilateral psoas muscle density. We compared cancer-specific survival (CSS) between high ATPD and low ATPD groups and performed cox regression hazard analyses to identify the predictors of CSS. Median ATPD was 44 HU (quartile: 39–47 Hounsfield Units). Two-year CSS rate in overall patients was 76.6%. Patients with low ATPD (< 44 HU) had significantly lower CSS rate (P = 0.01) than patients with high ATPD (≥ 44 HU). According to multivariate analysis, significant independent predictors of poor CSS were: Eastern Cooperative Oncology Group performance status ≥ 1 (P = 0.03), decreasing ATPD (P = 0.03), non-urothelial carcinoma (P = 0.01), pT ≥ 3 (P < 0.01), and pN positive (P < 0.01). In conclusion, myosteatosis (low ATPD) could be a novel predictor of prognosis after RC for bladder cancer.Shimpei YamashitaYuya IwahashiHaruka MiyaiTakashi IguchiHiroyuki KoikeSatoshi NishizawaNagahide MatsumuraKeizo HaginoKazuro KikkawaYasuo KohjimotoIsao HaraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shimpei Yamashita Yuya Iwahashi Haruka Miyai Takashi Iguchi Hiroyuki Koike Satoshi Nishizawa Nagahide Matsumura Keizo Hagino Kazuro Kikkawa Yasuo Kohjimoto Isao Hara Myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer
description	Abstract This study aims to evaluate the influence of myosteatosis on survival of patients after radical cystectomy (RC) for bladder cancer. We retrospectively identified 230 patients who underwent RC for bladder cancer at our three institutions between 2009 and 2018. Digitized free-hand outlines of the left and right psoas muscles were made on axial non-contrast computed tomography images at level L3. To assess myosteatosis, average total psoas density (ATPD) in Hounsfield Units (HU) was also calculated as an average of bilateral psoas muscle density. We compared cancer-specific survival (CSS) between high ATPD and low ATPD groups and performed cox regression hazard analyses to identify the predictors of CSS. Median ATPD was 44 HU (quartile: 39–47 Hounsfield Units). Two-year CSS rate in overall patients was 76.6%. Patients with low ATPD (< 44 HU) had significantly lower CSS rate (P = 0.01) than patients with high ATPD (≥ 44 HU). According to multivariate analysis, significant independent predictors of poor CSS were: Eastern Cooperative Oncology Group performance status ≥ 1 (P = 0.03), decreasing ATPD (P = 0.03), non-urothelial carcinoma (P = 0.01), pT ≥ 3 (P < 0.01), and pN positive (P < 0.01). In conclusion, myosteatosis (low ATPD) could be a novel predictor of prognosis after RC for bladder cancer.
format	article
author	Shimpei Yamashita Yuya Iwahashi Haruka Miyai Takashi Iguchi Hiroyuki Koike Satoshi Nishizawa Nagahide Matsumura Keizo Hagino Kazuro Kikkawa Yasuo Kohjimoto Isao Hara
author_facet	Shimpei Yamashita Yuya Iwahashi Haruka Miyai Takashi Iguchi Hiroyuki Koike Satoshi Nishizawa Nagahide Matsumura Keizo Hagino Kazuro Kikkawa Yasuo Kohjimoto Isao Hara
author_sort	Shimpei Yamashita
title	Myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer
title_short	Myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer
title_full	Myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer
title_fullStr	Myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer
title_full_unstemmed	Myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer
title_sort	myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/24cb45c29d9c42cf9b481c3434545fbc
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Myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer

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